Reactome | ATP6V1A [cytosol]

ATP6V1A [cytosol]

Stable Identifier

R-CEL-912602

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

Q9XW92

Locations in the PathwayBrowser

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Cellular responses to stimuli (Caenorhabditis elegans)

- Cellular responses to stress (Caenorhabditis elegans)
  - Cellular response to starvation (Caenorhabditis elegans)
    - Amino acids regulate mTORC1 (Caenorhabditis elegans)
      - RRAGA,B exchanges GDP for GTP (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A [cytosol] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A [cytosol] (Caenorhabditis elegans)
      - RRAGA,B hydrolyzes GTP (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A [cytosol] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A [cytosol] (Caenorhabditis elegans)
      - RRAGC,D exchanges GTP for GDP (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A [cytosol] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A [cytosol] (Caenorhabditis elegans)
      - RRAGC,D hydrolyzes GTP (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A [cytosol] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A [cytosol] (Caenorhabditis elegans)
      - mTORC1 binds RHEB:GTP (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A [cytosol] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A [cytosol] (Caenorhabditis elegans)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A [cytosol] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A [cytosol] (Caenorhabditis elegans)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A [cytosol] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A [cytosol] (Caenorhabditis elegans)
      - v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A [cytosol] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A [cytosol] (Caenorhabditis elegans)

Signal Transduction (Caenorhabditis elegans)

- Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
  - Signaling by Insulin receptor (Caenorhabditis elegans)
    - Insulin receptor recycling (Caenorhabditis elegans)
      - ATP6AP1 binds V-ATPase (Caenorhabditis elegans)
        
        V-ATPase [endosome membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A [cytosol] (Caenorhabditis elegans)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Caenorhabditis elegans)
        
        V-ATPase [endosome membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A [cytosol] (Caenorhabditis elegans)
      - Endosome acidification (Caenorhabditis elegans)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Caenorhabditis elegans)
        
        V-ATPase [endosome membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A [cytosol] (Caenorhabditis elegans)

Transport of small molecules (Caenorhabditis elegans)

- Ion channel transport (Caenorhabditis elegans)
  - ATP6AP1 binds V-ATPase (Caenorhabditis elegans)
    - V-ATPase [endosome membrane] (Caenorhabditis elegans)
      - ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A [cytosol] (Caenorhabditis elegans)
    - V-ATPase:ATP6AP1 [endosome membrane] (Caenorhabditis elegans)
      - V-ATPase [endosome membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A [cytosol] (Caenorhabditis elegans)
- Iron uptake and transport (Caenorhabditis elegans)
  - Transferrin endocytosis and recycling (Caenorhabditis elegans)
    - ATP6AP1 binds V-ATPase (Caenorhabditis elegans)
      - V-ATPase [endosome membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A [cytosol] (Caenorhabditis elegans)
      - V-ATPase:ATP6AP1 [endosome membrane] (Caenorhabditis elegans)
        
        V-ATPase [endosome membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A [cytosol] (Caenorhabditis elegans)
    - Acidification of Tf:TfR1 containing endosome (Caenorhabditis elegans)
      - V-ATPase:ATP6AP1 [endosome membrane] (Caenorhabditis elegans)
        
        V-ATPase [endosome membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1A [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q9XW92

Reference Genes

BioGPS Gene:3564970

ENSEMBL:WBGene00013025

Monarch:3564970

NCBI Gene:3564970

UCSC:Q9XW92

Wormbase:WBGene00013025

Reference Transcript

RefSeq:NM_074158.4

Other Identifiers

171984_at

18579422

193987_s_at

3564970

A_12_P103722

A_12_P134705

A_12_P134706

A_12_P134707

A_12_P175844

A_12_P175869

CE22210

CE22211

CE_WBGene00013025_A

CE_WBGene00013025_B

CE_WBGene00013025_C

CGZ0047307

GO:0003824

GO:0005215

GO:0005524

GO:0016787

GO:0016887

GO:0033180

GO:0046034

GO:0046961

GO:0055085

GO:0055086

GO:0140657

GO:1901135

GO:1902600

WBGene00013025

Y49A3A.2

Y49A3A.2_1545-1604_0.938_4_C

Y49A3A.2_1623-1682_0.940_1_B

Y49A3A.2_1767-1826_0.939_2_A

Y49A3A.3

Y49A3A_2P00370

Y49A3A_2P00982

Y49A3A_2P01296

Y49A3A_3P00200

cea2.c.39822

cea2.p.128988

Participates

as a component of

ATP6V1A trimer [cytosol] (Caenorhabditis elegans)

Inferred From

ATP6V1A [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_506559.1

IntEnz

7.1.2.2

PRO

Q9XW92

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