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IL6R [extracellular region]
Stable Identifier
R-CFA-1067661
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
extracellular region
Synonyms
IL6R-2, A0A8I3NUE0
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-6 family signaling (Canis familiaris)
Interleukin-6 signaling (Canis familiaris)
Assembly of hexameric IL-6 receptor (Canis familiaris)
IL6 receptor hexamer:JAKs [plasma membrane] (Canis familiaris)
IL6 receptor trimer:JAKs [plasma membrane] (Canis familiaris)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Canis familiaris)
IL6:IL6R-2 [extracellular region] (Canis familiaris)
IL6R [extracellular region] (Canis familiaris)
IL6 receptor trimer:JAKs [plasma membrane] (Canis familiaris)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Canis familiaris)
IL6:IL6R-2 [extracellular region] (Canis familiaris)
IL6R [extracellular region] (Canis familiaris)
IL6 binds IL6R-2 (Canis familiaris)
IL6:IL6R-2 [extracellular region] (Canis familiaris)
IL6R [extracellular region] (Canis familiaris)
IL6R [extracellular region] (Canis familiaris)
IL6:IL6R-2 binds IL6ST-2 (Canis familiaris)
IL6:IL6R-2 [extracellular region] (Canis familiaris)
IL6R [extracellular region] (Canis familiaris)
IL6:IL6R-2:IL6ST-2 [extracellular region] (Canis familiaris)
IL6:IL6R-2 [extracellular region] (Canis familiaris)
IL6R [extracellular region] (Canis familiaris)
IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Canis familiaris)
IL6:IL6R-2 [extracellular region] (Canis familiaris)
IL6R [extracellular region] (Canis familiaris)
IL6:IL6R-2:IL6ST-2 [extracellular region] (Canis familiaris)
IL6:IL6R-2 [extracellular region] (Canis familiaris)
IL6R [extracellular region] (Canis familiaris)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Canis familiaris)
IL6:IL6R-2 [extracellular region] (Canis familiaris)
IL6R [extracellular region] (Canis familiaris)
IL6ST is tyrosine phosphorylated (Canis familiaris)
IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
IL6 receptor trimer:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6R-2 [extracellular region] (Canis familiaris)
IL6R [extracellular region] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6R-2 [extracellular region] (Canis familiaris)
IL6R [extracellular region] (Canis familiaris)
JAK activation (Canis familiaris)
IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
IL6 receptor trimer:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6R-2 [extracellular region] (Canis familiaris)
IL6R [extracellular region] (Canis familiaris)
IL6 receptor hexamer:JAKs [plasma membrane] (Canis familiaris)
IL6 receptor trimer:JAKs [plasma membrane] (Canis familiaris)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Canis familiaris)
IL6:IL6R-2 [extracellular region] (Canis familiaris)
IL6R [extracellular region] (Canis familiaris)
PTPN11 binds CBL (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6R-2 [extracellular region] (Canis familiaris)
IL6R [extracellular region] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6R-2 [extracellular region] (Canis familiaris)
IL6R [extracellular region] (Canis familiaris)
PTPN11 binds p-Y759-IL6ST (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6R-2 [extracellular region] (Canis familiaris)
IL6R [extracellular region] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6R-2 [extracellular region] (Canis familiaris)
IL6R [extracellular region] (Canis familiaris)
PTPN11 is phosphorylated (Canis familiaris)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6R-2 [extracellular region] (Canis familiaris)
IL6R [extracellular region] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6R-2 [extracellular region] (Canis familiaris)
IL6R [extracellular region] (Canis familiaris)
Phosphorylated STATs are released (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6R-2 [extracellular region] (Canis familiaris)
IL6R [extracellular region] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6R-2 [extracellular region] (Canis familiaris)
IL6R [extracellular region] (Canis familiaris)
SOCS3 binds IL6ST (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6R-2 [extracellular region] (Canis familiaris)
IL6R [extracellular region] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6R-2 [extracellular region] (Canis familiaris)
IL6R [extracellular region] (Canis familiaris)
Serine phosphorylation of STATs (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6R-2 [extracellular region] (Canis familiaris)
IL6R [extracellular region] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine/serine phosphorylated STAT1/3 [plasma membrane] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6R-2 [extracellular region] (Canis familiaris)
IL6R [extracellular region] (Canis familiaris)
Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6R-2 [extracellular region] (Canis familiaris)
IL6R [extracellular region] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6R-2 [extracellular region] (Canis familiaris)
IL6R [extracellular region] (Canis familiaris)
Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6R-2 [extracellular region] (Canis familiaris)
IL6R [extracellular region] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6R-2 [extracellular region] (Canis familiaris)
IL6R [extracellular region] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6R-2 [extracellular region] (Canis familiaris)
IL6R [extracellular region] (Canis familiaris)
Signal Transduction (Canis familiaris)
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF-independent MAPK1/3 activation (Canis familiaris)
MAPK1 (ERK2) activation (Canis familiaris)
MAP2K2 binds MAPK1 (Canis familiaris)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Canis familiaris)
IL6:IL6R-2 [extracellular region] (Canis familiaris)
IL6R [extracellular region] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3NUE0
Gene Names
IL6R
Reference Genes
BioGPS Gene:612271 IL6R
ENSEMBL:ENSCAFG00845014397.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845014397.1 IL6R
Monarch:612271 IL6R
NCBI Gene:612271 IL6R
Reference Transcript
RefSeq:XM_850012.3 IL6R
Other Identifiers
612271
Cfa.12995.1.S1_at
Cfa.2779.1.A1_at
CfaAffx.26287.1.S1_s_at
GO:0002376
GO:0004896
GO:0004897
GO:0004915
GO:0005138
GO:0005515
GO:0005576
GO:0005886
GO:0005896
GO:0008284
GO:0010573
GO:0016020
GO:0016324
GO:0019221
GO:0019899
GO:0019981
GO:0023052
GO:0030154
GO:0031018
GO:0032722
GO:0032755
GO:0034097
GO:0036211
GO:0042531
GO:0042803
GO:0048661
GO:0048856
GO:0050731
GO:0060089
GO:0070102
GO:0070110
GO:0070119
GO:0070120
GO:0072126
GO:0072540
Participates
as an input of
IL6 binds IL6R-2 (Canis familiaris)
as a component of
IL6:IL6R-2 [extracellular region] (Canis familiaris)
Other forms of this molecule
IL6R [plasma membrane]
Inferred From
IL6R-2 [extracellular region]
(Homo sapiens)
Cross References
RefSeq
XP_855105.1
OpenTargets
ENSG00000160712
Ensembl
ENSCAFT00845025805
,
ENSCAFP00845020331
,
ENSCAFG00845014397
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