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What is Reactome ?
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Ub [cytosol]
Stable Identifier
R-CFA-113595
Type
Set [DefinedSet]
Species
Canis familiaris
Compartment
cytosol
Synonyms
ubiquitin
Locations in the PathwayBrowser
Expand all
Autophagy (Canis familiaris)
Macroautophagy (Canis familiaris)
Selective autophagy (Canis familiaris)
Aggrephagy (Canis familiaris)
Aggresome dissociates from dynein and microtubule (Canis familiaris)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Canis familiaris)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Canis familiaris)
PolyUb-Misfolded Proteins [cytosol] (Canis familiaris)
Ub-misfolded nascent CFTR [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Canis familiaris)
PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Canis familiaris)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [cytosol] (Canis familiaris)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Canis familiaris)
PolyUb-Misfolded Proteins [cytosol] (Canis familiaris)
Ub-misfolded nascent CFTR [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Canis familiaris)
Misfolded proteins:PRKN:UBE2N:UBE2V1:Ub [cytosol] (Canis familiaris)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Canis familiaris)
Ub:UBE2N:UBE2V1 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Canis familiaris)
Ub:UBE2N:UBE2V1 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Parkin transfers Ub to misfolded proteins (Canis familiaris)
Misfolded proteins:PRKN:UBE2N:UBE2V1:Ub [cytosol] (Canis familiaris)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Canis familiaris)
Ub:UBE2N:UBE2V1 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Canis familiaris)
Ub-Misfolded Proteins [cytosol] (Canis familiaris)
Ub-misfolded nascent CFTR [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Canis familiaris)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Canis familiaris)
PolyUb-Misfolded Proteins [cytosol] (Canis familiaris)
Ub-misfolded nascent CFTR [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [cytosol] (Canis familiaris)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Canis familiaris)
PolyUb-Misfolded Proteins [cytosol] (Canis familiaris)
Ub-misfolded nascent CFTR [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
PolyUb-Misfolded proteins bind vimentin to form aggresome (Canis familiaris)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Canis familiaris)
PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Canis familiaris)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [cytosol] (Canis familiaris)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Canis familiaris)
PolyUb-Misfolded Proteins [cytosol] (Canis familiaris)
Ub-misfolded nascent CFTR [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Canis familiaris)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [cytosol] (Canis familiaris)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Canis familiaris)
PolyUb-Misfolded Proteins [cytosol] (Canis familiaris)
Ub-misfolded nascent CFTR [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Canis familiaris)
PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Canis familiaris)
PolyUb-Misfolded Proteins [cytosol] (Canis familiaris)
Ub-misfolded nascent CFTR [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Canis familiaris)
Ub-Misfolded Proteins [cytosol] (Canis familiaris)
Ub-misfolded nascent CFTR [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Pexophagy (Canis familiaris)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Cell Cycle (Canis familiaris)
Cell Cycle Checkpoints (Canis familiaris)
G1/S DNA Damage Checkpoints (Canis familiaris)
p53-Dependent G1/S DNA damage checkpoint (Canis familiaris)
p53-Dependent G1 DNA Damage Response (Canis familiaris)
Stabilization of p53 (Canis familiaris)
Autodegradation of the E3 ubiquitin ligase COP1 (Canis familiaris)
Autoubiquitination of phospho-COP1(Ser-387 ) (Canis familiaris)
Ub [cytosol] (Canis familiaris)
ubiquitinated phospho-COP1(ser-387) [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Proteasome mediated degradation of COP1 (Canis familiaris)
Ub [cytosol] (Canis familiaris)
ubiquitinated phospho-COP1(ser-387) [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
p53-Independent G1/S DNA damage checkpoint (Canis familiaris)
p53-Independent DNA Damage Response (Canis familiaris)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Canis familiaris)
Proteolytic degradation of ubiquitinated-Cdc25A (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub-p-S123-CDC25A [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Cell Cycle, Mitotic (Canis familiaris)
M Phase (Canis familiaris)
Mitotic Metaphase and Anaphase (Canis familiaris)
Mitotic Anaphase (Canis familiaris)
Separation of Sister Chromatids (Canis familiaris)
Degradation of multiubiquitinated Securin (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Mitotic G2-G2/M phases (Canis familiaris)
G2/M Transition (Canis familiaris)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Canis familiaris)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Proteasome-mediated degradation of PolyUb-FBXL7 (Canis familiaris)
Ub [cytosol] (Canis familiaris)
SCF-FBXL18 ubiquitinates FBXL7 (Canis familiaris)
Ub [cytosol] (Canis familiaris)
SCF-FBXL7 ubiquitinates AURKA (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Regulation of PLK1 Activity at G2/M Transition (Canis familiaris)
SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub-p-S252,S497,T501-BORA [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Regulation of mitotic cell cycle (Canis familiaris)
APC/C-mediated degradation of cell cycle proteins (Canis familiaris)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Canis familiaris)
Degradation of multiubiquitinated cell cycle proteins (Canis familiaris)
Ub [cytosol] (Canis familiaris)
multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Canis familiaris)
Ub [cytosol] (Canis familiaris)
multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Canis familiaris)
APC/C:Cdc20 mediated degradation of mitotic proteins (Canis familiaris)
APC/C:Cdc20 mediated degradation of Cyclin B (Canis familiaris)
Degradation of multiubiquitinated Cyclin B (Canis familiaris)
Ub [cytosol] (Canis familiaris)
multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Canis familiaris)
Ub [cytosol] (Canis familiaris)
multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
APC/C:Cdc20 mediated degradation of Securin (Canis familiaris)
Degradation of multiubiquitinated Securin (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Canis familiaris)
Ub [cytosol] (Canis familiaris)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Canis familiaris)
APC-Cdc20 mediated degradation of Nek2A (Canis familiaris)
Degradation of multiubiquitinated Nek2A (Canis familiaris)
Multiubiquitinated Nek2A [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Multiubiquitination of Nek2A (Canis familiaris)
Multiubiquitinated Nek2A [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Canis familiaris)
Degradation multiubiquitinated Cyclin A (Canis familiaris)
Ub [cytosol] (Canis familiaris)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Canis familiaris)
Ub [cytosol] (Canis familiaris)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
S Phase (Canis familiaris)
Synthesis of DNA (Canis familiaris)
Switching of origins to a post-replicative state (Canis familiaris)
CDK-mediated phosphorylation and removal of Cdc6 (Canis familiaris)
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Canis familiaris)
Ub [cytosol] (Canis familiaris)
ubiquitinated Cdc6 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ubiquitinated Cdc6 is degraded by the proteasome (Canis familiaris)
Ub [cytosol] (Canis familiaris)
ubiquitinated Cdc6 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Orc1 removal from chromatin (Canis familiaris)
Ubiquitinated Orc1 is degraded by the proteasome (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Cellular responses to external stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to hypoxia (Canis familiaris)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Canis familiaris)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Canis familiaris)
UBE2D1,2,3:Ubiquitin [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Canis familiaris)
ub-hydroxyPro-HIF-alpha [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
DNA Replication (Canis familiaris)
DNA Replication Pre-Initiation (Canis familiaris)
Assembly of the pre-replicative complex (Canis familiaris)
CDT1 association with the CDC6:ORC:origin complex (Canis familiaris)
The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Canis familiaris)
Ub [cytosol] (Canis familiaris)
geminin:ubiquitin complex [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ubiquitinated geminin is degraded by the proteasome (Canis familiaris)
Ub [cytosol] (Canis familiaris)
geminin:ubiquitin complex [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Synthesis of DNA (Canis familiaris)
Switching of origins to a post-replicative state (Canis familiaris)
CDK-mediated phosphorylation and removal of Cdc6 (Canis familiaris)
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Canis familiaris)
Ub [cytosol] (Canis familiaris)
ubiquitinated Cdc6 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ubiquitinated Cdc6 is degraded by the proteasome (Canis familiaris)
Ub [cytosol] (Canis familiaris)
ubiquitinated Cdc6 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Orc1 removal from chromatin (Canis familiaris)
Ubiquitinated Orc1 is degraded by the proteasome (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Canis familiaris)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Canis familiaris)
Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Canis familiaris)
Ub-SMAD4 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Transcriptional regulation by RUNX1 (Canis familiaris)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Canis familiaris)
26S proteasome degrades TP73 polyubiquitinated by ITCH (Canis familiaris)
Ub [cytosol] (Canis familiaris)
ITCH polyubiquitinates TP73 (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Transcriptional regulation by RUNX3 (Canis familiaris)
Regulation of RUNX3 expression and activity (Canis familiaris)
Polyubiquitinated RUNX3 is degraded by the proteasome (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Class I MHC mediated antigen processing & presentation (Canis familiaris)
Antigen processing: Ubiquitination & Proteasome degradation (Canis familiaris)
E1 mediated ubiquitin activation (Canis familiaris)
E1 bound ubiquitin [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Interaction of E3 with substrate and E2-Ub complex (Canis familiaris)
Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
Ubiquitin:E2 conjugating enzymes [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ubiquitin:E2 conjugating enzymes [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Polyubiquitination of substrate (Canis familiaris)
E3:Ub:substrate [cytosol] (Canis familiaris)
Ub:substrate [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ubiquitin:E2 conjugating enzymes [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Proteasomal cleavage of substrate (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Transfer of Ub from E2 to substrate and release of E2 (Canis familiaris)
Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
Ubiquitin:E2 conjugating enzymes [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
E3:Ub:substrate [cytosol] (Canis familiaris)
Ub:substrate [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Transfer of ubiquitin from E1 to E2 (Canis familiaris)
E1 bound ubiquitin [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ubiquitin:E2 conjugating enzymes [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
FLT3 Signaling (Canis familiaris)
Negative regulation of FLT3 (Canis familiaris)
Ubiquitination of FLT3 (Canis familiaris)
Ub [cytosol] (Canis familiaris)
TNFR2 non-canonical NF-kB pathway (Canis familiaris)
NIK-->noncanonical NF-kB signaling (Canis familiaris)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
Alpha-protein kinase 1 signaling pathway (Canis familiaris)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Canis familiaris)
Ub [cytosol] (Canis familiaris)
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
Dectin-1 mediated noncanonical NF-kB signaling (Canis familiaris)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Cytosolic sensors of pathogen-associated DNA (Canis familiaris)
Regulation of innate immune responses to cytosolic DNA (Canis familiaris)
DDX41 ubiquitination by TRIM21 (Canis familiaris)
Ub [cytosol] (Canis familiaris)
STING ubiquitination by TRIM32 or TRIM56 (Canis familiaris)
Ub [cytosol] (Canis familiaris)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Canis familiaris)
Negative regulators of DDX58/IFIH1 signaling (Canis familiaris)
CYLD mediated deubiquitination of DDX58 (RIG-I) (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Metabolism of RNA (Canis familiaris)
Regulation of mRNA stability by proteins that bind AU-rich elements (Canis familiaris)
AUF1 (hnRNP D0) binds and destabilizes mRNA (Canis familiaris)
AUF1 (hnRNP D0) is ubiquitinylated (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Asparagine N-linked glycosylation (Canis familiaris)
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Canis familiaris)
Calnexin/calreticulin cycle (Canis familiaris)
ER Quality Control Compartment (ERQC) (Canis familiaris)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Canis familiaris)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [endoplasmic reticulum quality control compartment] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Canis familiaris)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Canis familiaris)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Deubiquitination (Canis familiaris)
Ovarian tumor domain proteases (Canis familiaris)
OTUD7A hydrolyses K11diUb (Canis familiaris)
Ub [cytosol] (Canis familiaris)
UCH proteinases (Canis familiaris)
UCHL1, UCHL3 cleave ubiquitin adducts (Canis familiaris)
UCHL1,UCHL3:Ub [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub-specific processing proteases (Canis familiaris)
CYLD mediated deubiquitination of DDX58 (RIG-I) (Canis familiaris)
Ub [cytosol] (Canis familiaris)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Canis familiaris)
Ub [cytosol] (Canis familiaris)
USP34 deubiquitinates AXIN1,AXIN2 (Canis familiaris)
Ub [cytosol] (Canis familiaris)
USP5 cleaves polyubiquitin (Canis familiaris)
USP5:Ub [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
USP8 deubiquitinates STAM2:HGS (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Protein ubiquitination (Canis familiaris)
E3 ubiquitin ligases ubiquitinate target proteins (Canis familiaris)
PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Canis familiaris)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Canis familiaris)
Ub:UBE2D1,2,3 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub:UBE2D1,2,3 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Canis familiaris)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Canis familiaris)
Ub:UBE2D1,2,3 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 [peroxisomal membrane] (Canis familiaris)
Ub:PEX5L [peroxisomal membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Canis familiaris)
RNF144A:PRKDC:Ub:UBE2L3 [cytosol] (Canis familiaris)
Ub:UBE2L3 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub:UBE2L3 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
RNF144A polyubiquitinates PRKDC (Canis familiaris)
RNF144A:PRKDC:Ub:UBE2L3 [cytosol] (Canis familiaris)
Ub:UBE2L3 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub:UBE2L3 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
RNF181 binds BCL10 and Ubiquitin:E2 (Canis familiaris)
RNF181:BCL10:Ub:E2 [cytoplasm] (Canis familiaris)
Ub:UBE2D1,UBE2D2,UBE2D3, UBE2E1,UBE2N [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub:UBE2D1,UBE2D2,UBE2D3, UBE2E1,UBE2N [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
RNF181 polyubiquinates BCL10 (Canis familiaris)
RNF181:BCL10:Ub:E2 [cytoplasm] (Canis familiaris)
Ub:UBE2D1,UBE2D2,UBE2D3, UBE2E1,UBE2N [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub:UBE2D1,UBE2D2,UBE2D3, UBE2E1,UBE2N [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Canis familiaris)
UBA1 adenylates ubiquitin in the cytosol (Canis familiaris)
Ub [cytosol] (Canis familiaris)
UBA1 conjugates ubiquitin to UBA1 in the cytosol (Canis familiaris)
Ub-Cys632-UBA1 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Canis familiaris)
Ub-Cys632-UBA1:ubiquitin adenylate [cytosol] (Canis familiaris)
Ub-Cys632-UBA1 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub:E2 (UBA1 substrate) [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Canis familiaris)
Ub-Cys625-UBA6:ubiquitin adenylate [cytosol] (Canis familiaris)
Ub-Cys625-UBA6 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub:E2 (UBA6 substrate) [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub-Cys632-UBA1 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub-Cys632-UBA1:ubiquitin adenylate [cytosol] (Canis familiaris)
Ub-Cys632-UBA1 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Programmed Cell Death (Canis familiaris)
Regulated Necrosis (Canis familiaris)
RIPK1-mediated regulated necrosis (Canis familiaris)
Regulation of necroptotic cell death (Canis familiaris)
STUB1 ubiquitinates RIPK3 at K55, K363 (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Protein localization (Canis familiaris)
Peroxisomal protein import (Canis familiaris)
PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Canis familiaris)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane] (Canis familiaris)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 [peroxisomal membrane] (Canis familiaris)
Ub:PEX5L [peroxisomal membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub:PEX5L [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Canis familiaris)
PEX2:PEX10:PEX12:PEX5L:Ub:UBE2D1,2,3:PEX7:PEX13:PEX14 [peroxisomal membrane] (Canis familiaris)
Ub:UBE2D1,2,3 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub:UBE2D1,2,3 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Canis familiaris)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Canis familiaris)
Ub:UBE2D1,2,3 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub:UBE2D1,2,3 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Canis familiaris)
PEX2:PEX10:PEX12:PEX5L:Ub:UBE2D1,2,3:PEX7:PEX13:PEX14 [peroxisomal membrane] (Canis familiaris)
Ub:UBE2D1,2,3 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 [peroxisomal membrane] (Canis familiaris)
Ub:PEX5L [peroxisomal membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Canis familiaris)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Canis familiaris)
Ub:UBE2D1,2,3 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 [peroxisomal membrane] (Canis familiaris)
Ub:PEX5L [peroxisomal membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Canis familiaris)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 [peroxisomal membrane] (Canis familiaris)
Ub:PEX5L [peroxisomal membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane] (Canis familiaris)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 [peroxisomal membrane] (Canis familiaris)
Ub:PEX5L [peroxisomal membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Canis familiaris)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 [peroxisomal membrane] (Canis familiaris)
Ub:PEX5L [peroxisomal membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane] (Canis familiaris)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 [peroxisomal membrane] (Canis familiaris)
Ub:PEX5L [peroxisomal membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Death Receptor Signalling (Canis familiaris)
TNF signaling (Canis familiaris)
Regulation of TNFR1 signaling (Canis familiaris)
RIPK1 is deubiquitinated (Canis familiaris)
Ub [cytosol] (Canis familiaris)
p75 NTR receptor-mediated signalling (Canis familiaris)
p75NTR signals via NF-kB (Canis familiaris)
NF-kB is activated and signals survival (Canis familiaris)
IkB is ubiquitinated and degraded (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ubiquitinated phospho-IkB [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
p75NTR recruits signalling complexes (Canis familiaris)
TRAF6 is auto-ubiquitinated (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
PTEN Regulation (Canis familiaris)
Regulation of PTEN localization (Canis familiaris)
PTEN undergoes monoubiquitination (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Regulation of PTEN stability and activity (Canis familiaris)
MKRN1 polyubiquitinates PTEN (Canis familiaris)
Ub [cytosol] (Canis familiaris)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Proteasome degrades polyubiquitinated PTEN (Canis familiaris)
Ub [cytosol] (Canis familiaris)
RNF146 polyubiquitinates PARylated PTEN (Canis familiaris)
Ub [cytosol] (Canis familiaris)
TRIM27 polyubiquitinates PTEN (Canis familiaris)
Ub [cytosol] (Canis familiaris)
USP13 and OTUD3 deubiquitinate PTEN (Canis familiaris)
Ub [cytosol] (Canis familiaris)
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
Negative regulation of MAPK pathway (Canis familiaris)
BRAP autoubiquitinates (Canis familiaris)
Ub [cytosol] (Canis familiaris)
MAPK6/MAPK4 signaling (Canis familiaris)
MAPK6 is degraded by the 26S proteasome (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Signaling by Hedgehog (Canis familiaris)
Hedgehog 'on' state (Canis familiaris)
NUMB:ITCH ubiquitinates GLI1 (Canis familiaris)
Ub [cytosol] (Canis familiaris)
ub-GLI is degraded by the proteasome (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Hedgehog ligand biogenesis (Canis familiaris)
Hh C-terminal fragments are degraded by the proteasome (Canis familiaris)
Ub [cytosol] (Canis familiaris)
SYVN1 ubiquitinates Hh C-terminal fragments (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Signaling by Non-Receptor Tyrosine Kinases (Canis familiaris)
Signaling by PTK6 (Canis familiaris)
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 (Canis familiaris)
CBL autoubiquitinates (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by EGFR (Canis familiaris)
EGFR downregulation (Canis familiaris)
CBL binds and ubiquitinates phosphorylated Sprouty (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Canis familiaris)
Ub-p-Y53/55-SPRY1/2 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub-Beta-Pix:CDC42:GTP [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
CBL ubiquitinates Sprouty (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Canis familiaris)
Ub-p-Y53/55-SPRY1/2 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
CBL-mediated ubiquitination of CIN85 (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ubiquitination of stimulated EGFR (CBL) (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ubiquitination of stimulated EGFR (CBL:GRB2) (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Signaling by ERBB2 (Canis familiaris)
Downregulation of ERBB2 signaling (Canis familiaris)
CHIP (STUB1) mediates ubiquitination of ERBB2 (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub-ERBB2:ERBIN:Ub-HSP90:CDC37 [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
CUL5 mediates ubiquitination of ERBB2 (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub-ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Downregulation of ERBB2:ERBB3 signaling (Canis familiaris)
Deubiquitination of RNF41 by P-USP8 (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub-RNF41:p-USP8 [cytosol] (Canis familiaris)
Ub-RNF41 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
RNF41 ubiquitinates ERBB3 (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub-ERBB3 [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
RNF41 ubiquitinates activated ERBB3 (Canis familiaris)
NRG1/2:Ub-p-10Y-ERBB3:p-ERBB2 [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Self-ubiquitination of RNF41 (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub-RNF41 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ubiquitinated RNF41 binds P-USP8 (Canis familiaris)
Ub-RNF41 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub-RNF41:p-USP8 [cytosol] (Canis familiaris)
Ub-RNF41 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Signaling by ERBB4 (Canis familiaris)
Downregulation of ERBB4 signaling (Canis familiaris)
ERBB4 ubiquitination by WWP1/ITCH (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub-ERBB4:WWP1/ITCH [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub-ERBB4jmAcyt1s80:NEDD4 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Signaling by FGFR (Canis familiaris)
Signaling by FGFR1 (Canis familiaris)
Negative regulation of FGFR1 signaling (Canis familiaris)
CBL ubiquitinates FRS2 and FGFR1 (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Spry regulation of FGF signaling (Canis familiaris)
CBL dissociates from ubiquitinated p-SPRY2 (Canis familiaris)
Ub-(Y55/Y227)p-SPRY2 [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Phosphorylated SPRY2 is ubiquitinated by CBL (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Signaling by FGFR2 (Canis familiaris)
Negative regulation of FGFR2 signaling (Canis familiaris)
CBL ubiquitinates FRS2 and FGFR2 (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Spry regulation of FGF signaling (Canis familiaris)
CBL dissociates from ubiquitinated p-SPRY2 (Canis familiaris)
Ub-(Y55/Y227)p-SPRY2 [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Phosphorylated SPRY2 is ubiquitinated by CBL (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Signaling by FGFR3 (Canis familiaris)
Negative regulation of FGFR3 signaling (Canis familiaris)
CBL ubiquitinates FRS2 and FGFR3 (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub-Activated FGFR3 complex:Ub-p-FRS2 [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Spry regulation of FGF signaling (Canis familiaris)
CBL dissociates from ubiquitinated p-SPRY2 (Canis familiaris)
Ub-(Y55/Y227)p-SPRY2 [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Phosphorylated SPRY2 is ubiquitinated by CBL (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Signaling by FGFR4 (Canis familiaris)
Negative regulation of FGFR4 signaling (Canis familiaris)
CBL ubiquitinates FRS2 and FGFR4 (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub-Activated FGFR4 complex:Ub-p-FRS2 [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Spry regulation of FGF signaling (Canis familiaris)
CBL dissociates from ubiquitinated p-SPRY2 (Canis familiaris)
Ub-(Y55/Y227)p-SPRY2 [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Phosphorylated SPRY2 is ubiquitinated by CBL (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Signaling by MET (Canis familiaris)
Negative regulation of MET activity (Canis familiaris)
CBL monoubiquitinates activated MET (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Signaling by TGFB family members (Canis familiaris)
Signaling by TGF-beta Receptor Complex (Canis familiaris)
TGF-beta receptor signaling activates SMADs (Canis familiaris)
Downregulation of TGF-beta receptor signaling (Canis familiaris)
Degradation of TGF-beta receptor complex (Canis familiaris)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Degradation of ubiquitinated SMAD2 (Canis familiaris)
Ub-SMAD2 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Degradation of ubiquitinated SMAD3 (Canis familiaris)
Ub-SMAD3 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
STUB1 (CHIP) ubiquitinates SMAD3 (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub-SMAD3 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (Canis familiaris)
Disassembly of tight junctions (Canis familiaris)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
SMURF1 ubiquitinates RHOA (Canis familiaris)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Canis familiaris)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Canis familiaris)
Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Canis familiaris)
Ub-SMAD4 [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Signaling by WNT (Canis familiaris)
Beta-catenin independent WNT signaling (Canis familiaris)
PCP/CE pathway (Canis familiaris)
Asymmetric localization of PCP proteins (Canis familiaris)
SMURF1/2 ubiquitinates PRICKLE1 (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Degradation of beta-catenin by the destruction complex (Canis familiaris)
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Canis familiaris)
Ub [cytosol] (Canis familiaris)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
TCF dependent signaling in response to WNT (Canis familiaris)
Degradation of AXIN (Canis familiaris)
RNF146 ubiquitinates ADP-ribosylated AXIN (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub-RibC-AXIN is degraded by the proteasome (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Degradation of DVL (Canis familiaris)
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Canis familiaris)
Ub [cytosol] (Canis familiaris)
DVL1 is ubiquitinated by HECW1 (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ubiquitinated DVL1 is degraded by the proteasome (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Regulation of FZD by ubiquitination (Canis familiaris)
USP8 deubiquitinates FZD to potentiate WNT signaling (Canis familiaris)
Ub [cytosol] (Canis familiaris)
ZNRF3 ubiquitinates FZD to promote its downregulation (Canis familiaris)
Ub [cytosol] (Canis familiaris)
USP34 deubiquitinates AXIN1,AXIN2 (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Transport of small molecules (Canis familiaris)
ABC-family proteins mediated transport (Canis familiaris)
RNF5 and RNF185 ubiquitinate misfolded CFTR (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
Ub-misfolded nascent CFTR [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Canis familiaris)
Ub-misfolded nascent CFTR [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
Ub-misfolded nascent CFTR [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
misfolded CFTR is degraded by the 26S proteasome (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ub-misfolded nascent CFTR [cytosol] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Ion channel transport (Canis familiaris)
Stimuli-sensing channels (Canis familiaris)
RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Iron uptake and transport (Canis familiaris)
SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Vesicle-mediated transport (Canis familiaris)
Membrane Trafficking (Canis familiaris)
Clathrin-mediated endocytosis (Canis familiaris)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
BAR domain proteins recruit dynamin (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Cargo recognition for clathrin-mediated endocytosis (Canis familiaris)
Epsin family proteins bind ubiquitinated cargo (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Clathrin recruits PIK3C2A (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Clathrin recruits auxilins to the clathrin-coated vesicle (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Canis familiaris)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Dissociation of clathrin-associated proteins (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Endophilins recruit synaptojanins to the clathrin-coated pit (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
F- and N- BAR domain proteins bind the clathrin-coated pit (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Canis familiaris)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
RAB5 and GAPVD1 bind AP-2 (Canis familiaris)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
SNX9 recruits components of the actin polymerizing machinery (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
ubiquitinated cargo [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Canis familiaris)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Canis familiaris)
Ub [cytosol] (Canis familiaris)
Participants
members
RPS27A [cytosol] (Canis familiaris)
UBA52 [cytosol] (Canis familiaris)
UBB(1-76) [cytosol] (Canis familiaris)
UBB(77-152) [cytosol] (Canis familiaris)
UBB(153-228) [cytosol] (Canis familiaris)
UBB [cytosol] (Canis familiaris)
Participant Of
hasComponent
E1 bound ubiquitin [cytosol]
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL [plasma membrane]
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane]
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane]
geminin:ubiquitin complex [cytosol]
K63 linked polyubiquitin chain [cytosol]
multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol]
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol]
multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol]
Multiubiquitinated Nek2A [cytosol]
NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol]
NRG1/2:Ub-p-10Y-ERBB3:p-ERBB2 [plasma membrane]
SCF-associated multiubiquitinated Emi1complexes [cytosol]
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane]
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction]
Ub-(Y55/Y227)p-SPRY2 [plasma membrane]
Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane]
Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane]
Ub-Activated FGFR3 complex:Ub-p-FRS2 [plasma membrane]
Ub-Activated FGFR4 complex:Ub-p-FRS2 [plasma membrane]
Ub-Beta-Pix:CDC42:GTP [cytosol]
Ub-Cys625-UBA6 [cytosol]
Ub-Cys632-UBA1 [cytosol]
Ub-ERBB2:ERBIN:HSP90:CDC37 [plasma membrane]
Ub-ERBB2:ERBIN:Ub-HSP90:CDC37 [plasma membrane]
Ub-ERBB3 [plasma membrane]
Ub-ERBB4:WWP1/ITCH [plasma membrane]
Ub-ERBB4jmAcyt1s80:NEDD4 [cytosol]
ub-hydroxyPro-HIF-alpha [cytosol]
Ub-misfolded nascent CFTR [cytosol]
Ub-p-S123-CDC25A [cytosol]
Ub-p-S252,S497,T501-BORA [cytosol]
Ub-p-Y53/55-SPRY1/2 [cytosol]
Ub-RNF41 [cytosol]
Ub-SMAD2 [cytosol]
Ub-SMAD3 [cytosol]
Ub-SMAD4 [cytosol]
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [cytosol]
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [endoplasmic reticulum quality control compartment]
Ub:E2 (UBA1 substrate) [cytosol]
Ub:E2 (UBA6 substrate) [cytosol]
Ub:PEX5L [cytosol]
Ub:PEX5L [peroxisomal membrane]
Ub:substrate [cytosol]
Ub:UBE2D1,2,3 [cytosol]
Ub:UBE2D1,UBE2D2,UBE2D3, UBE2E1,UBE2N [cytosol]
Ub:UBE2L3 [cytosol]
Ub:UBE2N [cytosol]
Ub:UBE2N:UBE2V1 [cytosol]
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane]
UBE2D1,2,3:Ubiquitin [cytosol]
Ubiquitin:E2 conjugating enzymes [cytosol]
ubiquitinated Cdc6 [cytosol]
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol]
ubiquitinated phospho-COP1(ser-387) [cytosol]
Ubiquitinated phospho-IkB [cytosol]
UCHL1,UCHL3:Ub [cytosol]
USP5:Ub [cytosol]
input
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation
AUF1 (hnRNP D0) is ubiquitinylated
Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer
Autoubiquitination of phospho-COP1(Ser-387 )
BRAP autoubiquitinates
CBL autoubiquitinates
CBL binds and ubiquitinates phosphorylated Sprouty
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix
CBL monoubiquitinates activated MET
CBL ubiquitinates FRS2 and FGFR1
CBL ubiquitinates FRS2 and FGFR2
CBL ubiquitinates FRS2 and FGFR3
CBL ubiquitinates FRS2 and FGFR4
CBL ubiquitinates Sprouty
CBL-mediated ubiquitination of CIN85
CHIP (STUB1) mediates ubiquitination of ERBB2
CUL5 mediates ubiquitination of ERBB2
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex
DDX41 ubiquitination by TRIM21
DVL is ubiquitinated by CUL3:KLHL12:RBX1
DVL1 is ubiquitinated by HECW1
E1 mediated ubiquitin activation
ERBB4 ubiquitination by WWP1/ITCH
IkB is ubiquitinated and degraded
ITCH polyubiquitinates TP73
MKRN1 polyubiquitinates PTEN
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)
Multiubiquitination of Nek2A
NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
NUMB:ITCH ubiquitinates GLI1
Phosphorylated SPRY2 is ubiquitinated by CBL
PTEN undergoes monoubiquitination
RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels
RNF146 polyubiquitinates PARylated PTEN
RNF146 ubiquitinates ADP-ribosylated AXIN
RNF41 ubiquitinates activated ERBB3
RNF41 ubiquitinates ERBB3
RNF5 and RNF185 ubiquitinate misfolded CFTR
SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA
SCF-FBXL18 ubiquitinates FBXL7
SCF-FBXL7 ubiquitinates AURKA
Self-ubiquitination of RNF41
SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2
SMURF1 ubiquitinates RHOA
SMURF1/2 ubiquitinates PRICKLE1
STING ubiquitination by TRIM32 or TRIM56
STUB1 (CHIP) ubiquitinates SMAD3
STUB1 ubiquitinates RIPK3 at K55, K363
SYVN1 ubiquitinates Hh C-terminal fragments
The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1
TRAF6 is auto-ubiquitinated
TRIM27 polyubiquitinates PTEN
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol
UBA1 adenylates ubiquitin in the cytosol
Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex
Ubiquitination of Cyclin A by APC/C:Cdc20 complex
Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex
Ubiquitination of FLT3
Ubiquitination of Securin by phospho-APC/C:Cdc20 complex
Ubiquitination of stimulated EGFR (CBL)
Ubiquitination of stimulated EGFR (CBL:GRB2)
ZNRF3 ubiquitinates FZD to promote its downregulation
output
26S proteasome degrades TP73 polyubiquitinated by ITCH
26S proteasome processes p-7S-p100:RELB to form p52:RELB
CYLD mediated deubiquitination of DDX58 (RIG-I)
Degradation multiubiquitinated Cyclin A
Degradation of multiubiquitinated cell cycle proteins
Degradation of multiubiquitinated Cyclin B
Degradation of multiubiquitinated Nek2A
Degradation of multiubiquitinated Securin
Deubiquitination of RNF41 by P-USP8
Hh C-terminal fragments are degraded by the proteasome
MAPK6 is degraded by the 26S proteasome
misfolded CFTR is degraded by the 26S proteasome
OTUD7A hydrolyses K11diUb
Polyubiquitinated RUNX3 is degraded by the proteasome
Proteasomal cleavage of substrate
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7
Proteasome degrades polyubiquitinated PTEN
Proteasome mediated degradation of COP1
Proteasome-mediated degradation of PolyUb-FBXL7
Proteolytic degradation of ubiquitinated-Cdc25A
RIPK1 is deubiquitinated
ub-GLI is degraded by the proteasome
Ub-RibC-AXIN is degraded by the proteasome
Ubiquitinated Cdc6 is degraded by the proteasome
Ubiquitinated DVL1 is degraded by the proteasome
Ubiquitinated geminin is degraded by the proteasome
Ubiquitinated Orc1 is degraded by the proteasome
USP13 and OTUD3 deubiquitinate PTEN
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1
USP30 deubiquitinates ATM dimer:Ub-p-PEX5
USP34 deubiquitinates AXIN1,AXIN2
USP5 cleaves polyubiquitin
USP8 deubiquitinates FZD to potentiate WNT signaling
USP8 deubiquitinates STAM2:HGS
Inferred From
Ub [cytosol] (Homo sapiens)
© 2021
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