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About
What is Reactome ?
News
Team
Scientific Advisory Board
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Release Calendar
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Our Logo
License Agreement
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Digital Preservation
Contact us
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Table of Contents
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Docs
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KLB [plasma membrane]
Stable Identifier
R-CFA-1307932
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
plasma membrane
Synonyms
KLB, A0A8I3RTN7
Locations in the PathwayBrowser
Expand all
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
RAS GEFs promote RAS nucleotide exchange (Canis familiaris)
RAS GEFs [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS3 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Activated FGFR4:pY-SHC1 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by FGFR (Canis familiaris)
Signaling by FGFR4 (Canis familiaris)
Downstream signaling of activated FGFR4 (Canis familiaris)
FRS-mediated FGFR4 signaling (Canis familiaris)
Activated FGFR4 binds FRS2 (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4 binds FRS3 (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:FRS3 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4 phosphorylates FRS2 (Canis familiaris)
Activated FGFR4:FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:p-8T-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4 phosphorylates FRS3 (Canis familiaris)
Activated FGFR4:FRS3 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS3 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4 phosphorylates PPTN11 (Canis familiaris)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS3 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS3 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS bind to PPTN11 (Canis familiaris)
Activated FGFR4:p-FRS [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS3 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS3 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS binds GRB2:SOS1 (Canis familiaris)
Activated FGFR4:p-FRS [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS3 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS3 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS3 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Canis familiaris)
Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS3 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
PI-3K cascade:FGFR4 (Canis familiaris)
Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Canis familiaris)
Activated FGFR4:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Canis familiaris)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Canis familiaris)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Phospholipase C-mediated cascade; FGFR4 (Canis familiaris)
Activated FGFR4 binds PLCG1 (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
activated FGFR4:PLCG1 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4 phosphorylates PLCG1 (Canis familiaris)
activated FGFR4:PLCG1 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
activated FGFR4:p-4Y-PLCG1 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
p-4Y-PLCG1 dissociates from activated FGFR4 (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
activated FGFR4:p-4Y-PLCG1 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
SHC-mediated cascade:FGFR4 (Canis familiaris)
Activated FGFR4 binds SHC1 (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:SHC1 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4 phosphorylates SHC1 (Canis familiaris)
Activated FGFR4:SHC1 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:pY-SHC1 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Canis familiaris)
Activated FGFR4:pY-SHC1 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Activated FGFR4:pY-SHC1 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Activated FGFR4:pY-SHC1 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
FGFR4 ligand binding and activation (Canis familiaris)
betaKlotho-mediated ligand binding (Canis familiaris)
Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
FGFR4:HS:KLB:FGF19 [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
FGFR4 binds HS:KLB:FGF19 (Canis familiaris)
FGFR4:HS:KLB:FGF19 [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Negative regulation of FGFR4 signaling (Canis familiaris)
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Canis familiaris)
Activated FGFR4:FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:p-8T-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
CBL ubiquitinates FRS2 and FGFR4 (Canis familiaris)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Ub-Activated FGFR4 complex:Ub-p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Canis familiaris)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Signaling by Insulin receptor (Canis familiaris)
Insulin receptor signalling cascade (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
PI3K-containing complexes [cytosol] (Canis familiaris)
Activated FGFR bound to PI3K [cytosol] (Canis familiaris)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Canis familiaris)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Canis familiaris)
IGF1R signaling cascade (Canis familiaris)
IRS-related events triggered by IGF1R (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
PI3K-containing complexes [cytosol] (Canis familiaris)
Activated FGFR bound to PI3K [cytosol] (Canis familiaris)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Canis familiaris)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR:p-FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
KLB [plasma membrane] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3RTN7
Gene Names
KLB
Reference Genes
BioGPS Gene:479110 KLB
ENSEMBL:ENSCAFG00845004657.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845004657.1 KLB
Monarch:479110 KLB
NCBI Gene:479110 KLB
Reference Transcript
RefSeq:XM_536257.5 KLB
Other Identifiers
479110
Cfa.8732.1.A1_s_at
GO:0003824
GO:0004553
GO:0005104
GO:0005975
GO:0008284
GO:0008543
GO:0016787
GO:0017134
GO:0023052
GO:0090080
Participates
as an input of
FGFR4 binds HS:KLB:FGF19 (Canis familiaris)
as a component of
FGFR4:HS:KLB:FGF19 [plasma membrane] (Canis familiaris)
Activated FGFR4 bound to FGF19:BetaKlotho [plasma membrane] (Canis familiaris)
Inferred From
KLB [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
XP_536257.1
OpenTargets
ENSG00000134962
Ensembl
ENSCAFG00845004657
,
ENSCAFT00845008330
,
ENSCAFP00845006555
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