Reactome | HGF [extracellular region]

HGF [extracellular region]

Stable Identifier

R-CFA-141767

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

extracellular region

Synonyms

HGF(495-728), Q867B7

Locations in the PathwayBrowser

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Hemostasis (Canis familiaris)

- Platelet activation, signaling and aggregation (Canis familiaris)
  - Response to elevated platelet cytosolic Ca2+ (Canis familiaris)
    - Platelet degranulation (Canis familiaris)
      - Exocytosis of platelet alpha granule contents (Canis familiaris)
        
        Platelet alpha granule contents [extracellular region] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Intracellular signaling by second messengers (Canis familiaris)
  - PIP3 activates AKT signaling (Canis familiaris)
    - Negative regulation of the PI3K/AKT network (Canis familiaris)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
        
        PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
        
        Activator:PI3K [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
    - PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
      - Activator:PI3K [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
- MAPK family signaling cascades (Canis familiaris)
  - MAPK1/MAPK3 signaling (Canis familiaris)
    - RAF/MAP kinase cascade (Canis familiaris)
      - RAS GEFs promote RAS nucleotide exchange (Canis familiaris)
        
        RAS GEFs [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Canis familiaris)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] (Canis familiaris)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] (Canis familiaris)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
- Signaling by Receptor Tyrosine Kinases (Canis familiaris)
  - Signaling by MET (Canis familiaris)
    - MET Receptor Activation (Canis familiaris)
      - HPN heterodimer cleaves pro-HGF to form HGF dimer (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
    - MET activates PI3K/AKT signaling (Canis familiaris)
      - MET bound PI3K generates PIP3 (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
      - MET phosphorylates GAB1 (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
      - Phosphorylated GAB1 recruits PI3K to MET (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
    - MET activates PTPN11 (Canis familiaris)
      - GAB1 binds PTPN11 (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PTPN11 [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
    - MET activates RAS signaling (Canis familiaris)
      - RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Canis familiaris)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
      - RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Canis familiaris)
        
        HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] (Canis familiaris)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
      - RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Canis familiaris)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] (Canis familiaris)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
    - MET promotes cell motility (Canis familiaris)
      - MET activates PTK2 signaling (Canis familiaris)
        
        MET phosphorylates PTK2 (Canis familiaris)
        
        HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2 [plasma membrane] (Canis familiaris)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:p-Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:p-Y397-PTK2 [plasma membrane] (Canis familiaris)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
        
        SRC phosphorylates PTK2 (Canis familiaris)
        
        HGF:p-4Y-MET dimer:p-Y194,Y397,Y576,Y577-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:p-Y194,Y397,Y576,Y577-PTK2 [plasma membrane] (Canis familiaris)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2 [plasma membrane] (Canis familiaris)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
      - MET activates RAP1 and RAC1 (Canis familiaris)
        
        CRK,CRKL recruits RAC1 GEF to activated MET (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
        
        GAB1 recruits CRK,CRKL to MET (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
        
        RAPGEF1 activates RAP1 (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
        
        RAPGEF1 binds CRK,CRKL (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
    - MET receptor recycling (Canis familiaris)
      - GGA3 associates with activated MET receptor (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
    - Negative regulation of MET activity (Canis familiaris)
      - CBL monoubiquitinates activated MET (Canis familiaris)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Canis familiaris)
        
        HGF:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Canis familiaris)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
      - CBL recruits CIN85:endophilin to ubiquitinated MET (Canis familiaris)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Canis familiaris)
        
        HGF:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Canis familiaris)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Canis familiaris)
        
        HGF:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
      - EPS15 and HGS bind ubiquitinated MET (Canis familiaris)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Canis familiaris)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Canis familiaris)
        
        HGF:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM) [plasma membrane] (Canis familiaris)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Canis familiaris)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Canis familiaris)
        
        HGF:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
      - MET phosphorylates CBL (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane] (Canis familiaris)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Canis familiaris)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Canis familiaris)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Canis familiaris)
        
        HGF dimer [extracellular region] (Canis familiaris)
        
        HGF [extracellular region] (Canis familiaris)

External Reference Information

External Reference

UniProt:Q867B7

Gene Names

HGF

Reference Genes

BioGPS Gene:403441 HGF

ENSEMBL:ENSCAFG00000006370

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000006370 HGF

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00030009302 HGF

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00040019820 HGF

KEGG Gene (Canis lupus familiaris):403441 HGF

Monarch:403441 HGF

NCBI Gene:403441 HGF

Reference Transcript

RefSeq:NM_001002964.1 HGF

Other Identifiers

403441

CfaAffx.10518.1.S1_s_at

GO:0000187

GO:0000902

GO:0001889

GO:0001934

GO:0003674

GO:0004252

GO:0006259

GO:0006464

GO:0006508

GO:0006950

GO:0007005

GO:0007165

GO:0007267

GO:0008083

GO:0008150

GO:0008219

GO:0008233

GO:0008283

GO:0009058

GO:0014068

GO:0030335

GO:0032715

GO:0032733

GO:0033137

GO:0034641

GO:0035729

GO:0040011

GO:0042056

GO:0042802

GO:0043066

GO:0043154

GO:0048012

GO:0048856

GO:0048870

GO:0050673

GO:0050728

GO:0050731

GO:0050918

GO:0051450

GO:0060326

GO:0060665

GO:0090201

GO:1900744

GO:1901299

GO:1902042

GO:1902947

GO:2000573

Participant Of

hasComponent

HGF dimer [extracellular region]

Other forms of this molecule

HGF [platelet alpha granule lumen]

HGF [extracellular region]

Inferred From

HGF(495-728) [extracellular region] (Homo sapiens)

Cross References

RefSeq

NP_001002964.1

OpenTargets

ENSG00000019991

Ensembl

ENSCAFP00000009539, ENSCAFT00000010288, ENSCAFG00000006370

VGNC

41674

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