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PABPC1 [cytosol]
Stable Identifier
R-CFA-156803
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
PABPC1, A0A8I3Q524
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Canis familiaris)
Deadenylation-dependent mRNA decay (Canis familiaris)
Deadenylation of mRNA (Canis familiaris)
CCR4-NOT complex deadenylates mRNA (Canis familiaris)
PABPC1 [cytosol] (Canis familiaris)
Partially Deadenylated mRNA Complex [cytosol] (Canis familiaris)
PABPC1 [cytosol] (Canis familiaris)
PAN2-PAN3 complex partially deadenylates mRNA (Canis familiaris)
Partially Deadenylated mRNA Complex [cytosol] (Canis familiaris)
PABPC1 [cytosol] (Canis familiaris)
Translatable mRNA Complex [cytosol] (Canis familiaris)
PABPC1 [cytosol] (Canis familiaris)
PARN deadenylates mRNA (Canis familiaris)
PABPC1 [cytosol] (Canis familiaris)
Partially Deadenylated mRNA Complex [cytosol] (Canis familiaris)
PABPC1 [cytosol] (Canis familiaris)
Nonsense-Mediated Decay (NMD) (Canis familiaris)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Canis familiaris)
Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Canis familiaris)
PABPC1 [cytosol] (Canis familiaris)
mRNA Cleaved by SMG6 [cytosol] (Canis familiaris)
PABPC1 [cytosol] (Canis familiaris)
SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Canis familiaris)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Canis familiaris)
PABPC1 [cytosol] (Canis familiaris)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Canis familiaris)
PABPC1 [cytosol] (Canis familiaris)
SMG6 hydrolyzes mRNA with premature termination codon (Canis familiaris)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Canis familiaris)
PABPC1 [cytosol] (Canis familiaris)
mRNA Cleaved by SMG6 [cytosol] (Canis familiaris)
PABPC1 [cytosol] (Canis familiaris)
UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Canis familiaris)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Canis familiaris)
PABPC1 [cytosol] (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Canis familiaris)
PABPC1 [cytosol] (Canis familiaris)
p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Canis familiaris)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Canis familiaris)
PABPC1 [cytosol] (Canis familiaris)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Canis familiaris)
PABPC1 [cytosol] (Canis familiaris)
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Canis familiaris)
Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Canis familiaris)
mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Canis familiaris)
PABPC1 [cytosol] (Canis familiaris)
UPF1:eRF3 Complex on Translated mRNA [cytosol] (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Canis familiaris)
mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Canis familiaris)
PABPC1 [cytosol] (Canis familiaris)
Regulation of mRNA stability by proteins that bind AU-rich elements (Canis familiaris)
AUF1 (hnRNP D0) binds and destabilizes mRNA (Canis familiaris)
AUF1 (hnRNP D0) is ubiquitinylated (Canis familiaris)
AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] (Canis familiaris)
PABPC1 [cytosol] (Canis familiaris)
AUF1 binds translation and heat shock proteins (Canis familiaris)
AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] (Canis familiaris)
PABPC1 [cytosol] (Canis familiaris)
PABPC1 [cytosol] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Translation (Canis familiaris)
Eukaryotic Translation Initiation (Canis familiaris)
Cap-dependent Translation Initiation (Canis familiaris)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Canis familiaris)
Translation initiation complex formation (Canis familiaris)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Canis familiaris)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Canis familiaris)
PABPC1 [cytosol] (Canis familiaris)
PABPC1 [cytosol] (Canis familiaris)
L13a-mediated translational silencing of Ceruloplasmin expression (Canis familiaris)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Canis familiaris)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Canis familiaris)
PABPC1 [cytosol] (Canis familiaris)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Canis familiaris)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Canis familiaris)
PABPC1 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3Q524
Gene Names
PABPC1
Reference Genes
ENSEMBL:ENSCAFG00845028663.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845028663.1 PABPC1
Other Identifiers
612751
CfaAffx.1789.1.S1_s_at
GO:0003676
GO:0003723
GO:0005737
Participates
as an input of
AUF1 binds translation and heat shock proteins (Canis familiaris)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Canis familiaris)
as a component of
AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] (Canis familiaris)
mRNA Cleaved by SMG6 [cytosol] (Canis familiaris)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Canis familiaris)
mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Canis familiaris)
Partially Deadenylated mRNA Complex [cytosol] (Canis familiaris)
Translatable mRNA Complex [cytosol] (Canis familiaris)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Canis familiaris)
as an output of
Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Canis familiaris)
PARN deadenylates mRNA (Canis familiaris)
CCR4-NOT complex deadenylates mRNA (Canis familiaris)
Inferred From
PABPC1 [cytosol]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000070756
Ensembl
ENSCAFT00845050693
,
ENSCAFG00845028663
,
ENSCAFP00845039739
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