Reactome | MLST8 [cytosol]

MLST8 [cytosol]

Stable Identifier

R-CFA-165676

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

MLST8, A0A8I3MX71

Locations in the PathwayBrowser

Expand all

Autophagy (Canis familiaris)

- Macroautophagy (Canis familiaris)
  - Active MTORC1 binds the ULK1 complex (Canis familiaris)
    - Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
    - MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Canis familiaris)
      - Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
  - Active MTORC1 phosphorylates ULK1 (Canis familiaris)
    - MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Canis familiaris)
      - Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
    - MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Canis familiaris)
      - Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
  - MTORC1 dissociates from ULK complex (Canis familiaris)
    - MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Canis familiaris)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Canis familiaris)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Canis familiaris)
        
        mTORC1 with p-S722,S792-RPTOR [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
    - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Canis familiaris)
      - mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Canis familiaris)
        
        mTORC1 with p-S722,S792-RPTOR [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
  - Rheb in the MTORC1 complex hydrolyses GTP (Canis familiaris)
    - Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
    - mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Canis familiaris)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
  - p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Canis familiaris)
    - MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Canis familiaris)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Canis familiaris)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Canis familiaris)
        
        mTORC1 with p-S722,S792-RPTOR [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
    - MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Canis familiaris)
      - Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)

Cellular responses to stimuli (Canis familiaris)

- Cellular responses to stress (Canis familiaris)
  - Cellular response to starvation (Canis familiaris)
    - Amino acids regulate mTORC1 (Canis familiaris)
      - RRAGA,B hydrolyzes GTP (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
      - mTORC1 binds RHEB:GTP (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)

Gene expression (Transcription) (Canis familiaris)

- RNA Polymerase II Transcription (Canis familiaris)
  - Generic Transcription Pathway (Canis familiaris)
    - Transcriptional Regulation by TP53 (Canis familiaris)
      - Regulation of TP53 Activity (Canis familiaris)
        
        Regulation of TP53 Expression and Degradation (Canis familiaris)
        
        Regulation of TP53 Degradation (Canis familiaris)
        
        TORC2 complex phosphorylates SGK1 (Canis familiaris)
        
        TORC2 complex [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
      - TP53 Regulates Metabolic Genes (Canis familiaris)
        
        RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Canis familiaris)
        
        Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
        
        mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Intracellular signaling by second messengers (Canis familiaris)
  - PIP3 activates AKT signaling (Canis familiaris)
    - PTEN Regulation (Canis familiaris)
      - Regulation of PTEN gene transcription (Canis familiaris)
        
        MAF1 translocates to the nucleus (Canis familiaris)
        
        Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
        
        mTORC1 phosphorylates MAF1 (Canis familiaris)
        
        Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
    - TORC2 complex phosphorylates SGK1 (Canis familiaris)
      - TORC2 complex [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
- MTOR signalling (Canis familiaris)
  - AKT1S1 (PRAS40) binds mTORC1 (Canis familiaris)
    - Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
    - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Canis familiaris)
      - Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
  - Energy dependent regulation of mTOR by LKB1-AMPK (Canis familiaris)
    - AMPK phosphorylates Raptor in the mTORC1 complex (Canis familiaris)
      - Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Canis familiaris)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Canis familiaris)
        
        mTORC1 with p-S722,S792-RPTOR [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
    - RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Canis familiaris)
      - Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
      - mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
  - Formation of active mTORC1 complex (Canis familiaris)
    - Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
    - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
      - mTORC1 [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
  - Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Canis familiaris)
    - mTORC1 [cytosol] (Canis familiaris)
      - MLST8 [cytosol] (Canis familiaris)
    - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
      - mTORC1 [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
  - mTORC1 phosphorylates AKT1S1 (Canis familiaris)
    - mTORC1:RHEB:GTP:p-S183,T246-AKT1S1:YWHAB [lysosomal membrane] (Canis familiaris)
      - mTORC1:RHEB:GTP:p-S183,T246-AKT1S1 [lysosomal membrane] (Canis familiaris)
        
        Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
    - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Canis familiaris)
      - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Canis familiaris)
        
        Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
  - mTORC1-mediated signalling (Canis familiaris)
    - Phosphorylation of 4E-BP1 by activated mTORC1 (Canis familiaris)
      - Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
      - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Canis familiaris)
        
        Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
      - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Canis familiaris)
        
        mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Canis familiaris)
        
        Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
    - mTORC1 phosphorylation of RPS6KB1 (S6K) (Canis familiaris)
      - Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Canis familiaris)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Canis familiaris)
        
        mTORC1 with p-S722,S792-RPTOR [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)
      - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Canis familiaris)
        
        mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Canis familiaris)
        
        Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        MLST8 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3MX71

Gene Names

MLST8

Reference Genes

BioGPS Gene:610936 MLST8

ENSEMBL:ENSCAFG00845004640.1

Monarch:610936 MLST8

NCBI Gene:610936 MLST8

UCSC:A0A8I3MX71 MLST8

Reference Transcript

RefSeq:XM_848525.3 MLST8

Other Identifiers

Cfa.7295.1.A1_at

Cfa.7761.1.A1_at

CfaAffx.29667.1.S1_at

GO:0005737

GO:0005765

GO:0030838

GO:0031929

GO:0031931

GO:0031932

GO:0032008

GO:0032956

GO:0038202

GO:0043539

GO:0050731

GO:0098772

Participates

as a component of

Other forms of this molecule

MLST8 [nucleoplasm]

Inferred From

MLST8 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_853618.1

ENSEMBL

ENSCAFT00845008314, ENSCAFP00845006542

Cite Us!