Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
IRF3 [cytosol]
Stable Identifier
R-CFA-166251
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
IRF3, F1P7J1
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Interferon Signaling (Canis familiaris)
Antiviral mechanism by IFN-stimulated genes (Canis familiaris)
ISG15 antiviral mechanism (Canis familiaris)
ISGylation of IRF3 (Canis familiaris)
IRF3 [cytosol] (Canis familiaris)
ISGylated IRF3 [cytosol] (Canis familiaris)
IRF3 [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
Cytosolic sensors of pathogen-associated DNA (Canis familiaris)
STING mediated induction of host immune responses (Canis familiaris)
IRF3-mediated induction of type I IFN (Canis familiaris)
IRF3 is phosphorylated by TBK1 (Canis familiaris)
NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Canis familiaris)
STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Canis familiaris)
IRF3 [cytosol] (Canis familiaris)
STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Canis familiaris)
IRF3 [cytosol] (Canis familiaris)
TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Canis familiaris)
STING:TBK1:IRF3 [cytoplasmic vesicle membrane] (Canis familiaris)
IRF3 [cytosol] (Canis familiaris)
STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Canis familiaris)
IRF3 [cytosol] (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88-independent TLR4 cascade (Canis familiaris)
TRIF(TICAM1)-mediated TLR4 signaling (Canis familiaris)
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon (Canis familiaris)
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Canis familiaris)
IRF3 [cytosol] (Canis familiaris)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKE:IRF3/IRF7 [endosome membrane] (Canis familiaris)
IRF3 [cytosol] (Canis familiaris)
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex (Canis familiaris)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKE:IRF3/IRF7 [endosome membrane] (Canis familiaris)
IRF3 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:F1P7J1
Gene Names
IRF3
Reference Genes
BioGPS Gene:476412 IRF3
ENSEMBL:ENSCAFG00000003594
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000003594 IRF3
KEGG Gene (Canis lupus familiaris):476412 IRF3
Monarch:476412 IRF3
NCBI Gene:476412 IRF3
Reference Transcript
RefSeq:XM_005616307.2 IRF3
Other Identifiers
476412
Cfa.2729.1.S1_s_at
GO:0000976
GO:0000981
GO:0002376
GO:0003674
GO:0003677
GO:0003700
GO:0005575
GO:0005622
GO:0005634
GO:0006355
GO:0006357
GO:0008150
GO:0009058
GO:0034641
GO:0043226
Participant Of
input
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
ISGylation of IRF3
hasComponent
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKE:IRF3/IRF7 [endosome membrane]
ISGylated IRF3 [cytosol]
STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane]
STING:TBK1:IRF3 [cytoplasmic vesicle membrane]
Other forms of this molecule
phospho-IRF3 [nucleoplasm]
phospho-IRF3 [nucleoplasm]
phospho-IRF3 [cytosol]
Inferred From
IRF3 [cytosol] (Homo sapiens)
IRF3,IRF7 [cytosol] (Homo sapiens)
Cross References
RefSeq
XP_005616364.1
OpenTargets
ENSG00000126456
Ensembl
ENSCAFT00000005783
,
ENSCAFP00000005354
,
ENSCAFG00000003594
VGNC
54848
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text