Reactome | IRF3 [cytosol]

IRF3 [cytosol]

Stable Identifier

R-CFA-166251

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

IRF3, F1P7J1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:F1P7J1

Gene Names

IRF3

Reference Genes

BioGPS Gene:476412 IRF3

ENSEMBL:ENSCAFG00000003594

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000003594 IRF3

Monarch:476412 IRF3

NCBI Gene:476412 IRF3

Reference Transcript

RefSeq:XM_005616307.2 IRF3

Other Identifiers

476412

Cfa.2729.1.S1_s_at

GO:0003674

GO:0003677

GO:0003700

GO:0005515

GO:0006355

GO:0008150

GO:0009058

GO:0034641

GO:0044212

Participant Of

input

IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
ISGylation of IRF3

hasComponent

activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKE:IRF3/IRF7 [endosome membrane]
ISGylated IRF3 [cytosol]
STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane]
STING:TBK1:IRF3 [cytoplasmic vesicle membrane]

Other forms of this molecule

phospho-IRF3 [nucleoplasm]

phospho-IRF3 [cytosol]

Inferred From

IRF3 [cytosol] (Homo sapiens)

IRF3,IRF7 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_005616364.1

OpenTargets

ENSG00000126456

Ensembl

ENSCAFT00000005783, ENSCAFG00000003594, ENSCAFP00000005354

VGNC

54848