Reactome | CD4 [plasma membrane]

CD4 [plasma membrane]

Stable Identifier

R-CFA-167542

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

CD4, P33705

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Canis familiaris)

- Membrane Trafficking (Canis familiaris)
  - Clathrin-mediated endocytosis (Canis familiaris)
    - BAR domain proteins recruit dynamin (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        CD4 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        CD4 [plasma membrane] (Canis familiaris)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Canis familiaris)
      - CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        CD4 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        CD4 [plasma membrane] (Canis familiaris)
    - Cargo recognition for clathrin-mediated endocytosis (Canis familiaris)
      - AP-2 directly binds some endocytic cargo (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        CD4 [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        CD4 [plasma membrane] (Canis familiaris)
    - Clathrin recruits PIK3C2A (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        CD4 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        CD4 [plasma membrane] (Canis familiaris)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        CD4 [plasma membrane] (Canis familiaris)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        CD4 [plasma membrane] (Canis familiaris)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        CD4 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        CD4 [plasma membrane] (Canis familiaris)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        CD4 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        CD4 [plasma membrane] (Canis familiaris)
    - SNX9 recruits components of the actin polymerizing machinery (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        CD4 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        CD4 [plasma membrane] (Canis familiaris)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        CD4 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        AP-2:cargo [plasma membrane] (Canis familiaris)
        
        AP-2 cargo [plasma membrane] (Canis familiaris)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)
        
        CD4 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:P33705

Gene Names

CD4

Reference Genes

BioGPS Gene:403931 CD4

ENSEMBL:ENSCAFG00000041713

KEGG:cfa:403931 CD4

Monarch:403931 CD4

NCBI Gene:403931 CD4

UCSC:P33705 CD4

Reference Transcript

RefSeq:NM_001003252.1 CD4

Other Identifiers

403931

Cfa.3673.1.S1_s_at

Cfa.3866.1.S1_s_at

GO:0002376

GO:0005886

GO:0006355

GO:0008270

GO:0009897

GO:0019899

GO:0019901

GO:0023026

GO:0030154

GO:0030217

GO:0030225

GO:0032507

GO:0035723

GO:0042011

GO:0042012

GO:0042289

GO:0042802

GO:0042803

GO:0043123

GO:0043410

GO:0045058

GO:0045121

GO:0045657

GO:0045893

GO:0046598

GO:0050863

GO:0051924

GO:0060089

GO:0070374

GO:0097011

GO:1990782

Participates

as a member of

AP-2 dileucine-containing cargo [plasma membrane] (Canis familiaris)

as a component of

as an input of

CD4 binds Interleukin-16 (Canis familiaris)

Other forms of this molecule

CD4 [clathrin-coated endocytic vesicle membrane]

Inferred From

CD4 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001003252.1

ENSEMBL

ENSCAFG00845027739, ENSCAFT00845048936, ENSCAFP00845038388

Cite Us!