Reactome | LCK [cytosol]

LCK [cytosol]

Stable Identifier

R-CFA-167609

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

LCK, A0A8I3NAC6

Locations in the PathwayBrowser

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Signal Transduction (Canis familiaris)

- Intracellular signaling by second messengers (Canis familiaris)
  - PIP3 activates AKT signaling (Canis familiaris)
    - Negative regulation of the PI3K/AKT network (Canis familiaris)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
        
        PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
        
        Activator:PI3K [plasma membrane] (Canis familiaris)
        
        CD28:PI3K [plasma membrane] (Canis familiaris)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
        
        FYN,LCK [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
    - PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
      - Activator:PI3K [plasma membrane] (Canis familiaris)
        
        CD28:PI3K [plasma membrane] (Canis familiaris)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
        
        FYN,LCK [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
- Signaling by Receptor Tyrosine Kinases (Canis familiaris)
  - Signaling by SCF-KIT (Canis familiaris)
    - Dimerization of STATs (Canis familiaris)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
    - Disassociation and translocation of STATs to the nucleus (Canis familiaris)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
    - GRB2 is indirectly recruited to p-KIT through SHP2 (Canis familiaris)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
      - p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
    - Indirect recruitment of GAB2 to p-KIT (Canis familiaris)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
    - Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Canis familiaris)
      - PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
    - JAK2 binds to p-KIT (Canis familiaris)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
      - SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
    - Phosphorylation and activation of VAV1 (Canis familiaris)
      - SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
      - Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
    - Phosphorylation of GAB2 by SFKs (Canis familiaris)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
      - Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
    - Phosphorylation of JAK2 (Canis familiaris)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
    - Phosphorylation of SHP2 by SFKs (Canis familiaris)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
      - Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
      - p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
    - Phosphorylation of STATs (Canis familiaris)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
    - Phosphorylation of p-KIT on Y900 by Src kinases (Canis familiaris)
      - SFKs:p-8Y-KIT:sSCF dimer:p-8Y-KIT [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
      - SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
      - Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
    - Recruitment of STATs (Canis familiaris)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
    - Regulation of KIT signaling (Canis familiaris)
      - Interaction of APS and p-KIT (Canis familiaris)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
      - Phosphorylation of APS (Canis familiaris)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
      - Recruitment of CBL to KIT (Canis familiaris)
        
        CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Canis familiaris)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Canis familiaris)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Canis familiaris)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
    - SHP2 interacts with p-KIT (Canis familiaris)
      - SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
    - Synthesis of PIP3 from PIP2 by PI3K (Canis familiaris)
      - PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
        
        SFKs:p-KIT complex [plasma membrane] (Canis familiaris)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
  - Signaling by Rho GTPases (Canis familiaris)
    - RHO GTPase cycle (Canis familiaris)
      - RHOH GTPase cycle (Canis familiaris)
        
        RHOH binds effectors at the plasma membrane (Canis familiaris)
        
        RHOH effectors [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)
        
        RHOH:GTP:RHOH effectors [plasma membrane] (Canis familiaris)
        
        RHOH effectors [cytosol] (Canis familiaris)
        
        LCK [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NAC6

Gene Names

LCK

Reference Genes

BioGPS Gene:478151 LCK

ENSEMBL:ENSCAFG00845004976.1

KEGG:cfa:478151 LCK

Monarch:478151 LCK

NCBI Gene:478151 LCK

UCSC:A0A8I3NAC6 LCK

Reference Transcript

RefSeq:XM_005617639.1 LCK

Other Identifiers

478151

Cfa.18965.1.S1_s_at

CfaAffx.16646.1.S1_at

GO:0000242

GO:0001772

GO:0001784

GO:0002376

GO:0003824

GO:0004713

GO:0004715

GO:0004722

GO:0005524

GO:0005737

GO:0005829

GO:0005886

GO:0006882

GO:0009410

GO:0016004

GO:0016740

GO:0016787

GO:0019901

GO:0019903

GO:0030154

GO:0030217

GO:0034116

GO:0035556

GO:0038094

GO:0042110

GO:0042169

GO:0042608

GO:0042609

GO:0042610

GO:0042802

GO:0043274

GO:0043548

GO:0045121

GO:0050852

GO:0050870

GO:0051117

GO:0098772

GO:0140096

GO:0160162

GO:1903039

GO:2001244

Participates

as a member of

as an input of

Active FLT3 binds to LCK (Canis familiaris)

as a component of

as a candidate of

SHC kinases in IL2 signaling [cytosol] (Canis familiaris)

Other forms of this molecule

phospho-LCK [plasma membrane]

phospho-LCK [cytosol]

Inferred From

LCK [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_005617696.1

ENSEMBL

ENSCAFP00845007011, ENSCAFT00845008902

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