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MAP3K14 [cytosol]
Stable Identifier
R-CFA-168189
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
A0A8I3MWN3
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Regulation of T cell activation by CD28 family (Canis familiaris)
Co-stimulation by CD28 (Canis familiaris)
CD28 dependent PI3K/Akt signaling (Canis familiaris)
p-S400-Cot phosphorylates NIK (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
TNFR2 non-canonical NF-kB pathway (Canis familiaris)
K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Canis familiaris)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Canis familiaris)
K48polyUb-TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
NIK-->noncanonical NF-kB signaling (Canis familiaris)
Activation of NIK (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
Active NIK phosphorylates IKKA dimer (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
NIK autophosphorylates on T559 (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Canis familiaris)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Canis familiaris)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
p100:RELB binds active NIK:p-IKKA dimer (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
Protesomal degradation of K48polyUb-TRAF3 (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Canis familiaris)
K48polyUb-TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Canis familiaris)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Canis familiaris)
CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Canis familiaris)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
TRAF2:cIAP1/2 complex binds FN14:TWEAK (Canis familiaris)
3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
TRAF3 binds BAFFR:BAFF (Canis familiaris)
3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
TRAFs bind RANK:RANKL (Canis familiaris)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Canis familiaris)
Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Canis familiaris)
3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
TRAF3:NIK binds TRAF2:cIAP1/2 (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Canis familiaris)
TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Canis familiaris)
TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF3:NIK [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
Dectin-1 mediated noncanonical NF-kB signaling (Canis familiaris)
Activation of NIK (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
Active NIK phosphorylates IKKA dimer (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Canis familiaris)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Canis familiaris)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
p100:RELB binds active NIK:p-IKKA dimer (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
MAP3K14 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3MWN3
Reference Genes
ENSEMBL:ENSCAFG00845005731.1
UCSC:A0A8I3MWN3
Other Identifiers
490926
CfaAffx.21280.1.S1_at
GO:0000166
GO:0001650
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0005524
GO:0005654
GO:0005737
GO:0005829
GO:0006468
GO:0006955
GO:0016301
GO:0016740
GO:0035556
GO:0038061
GO:0051607
GO:0071260
GO:0098542
GO:0140096
Participates
as an input of
NIK autophosphorylates on T559 (Canis familiaris)
p-S400-Cot phosphorylates NIK (Canis familiaris)
Active NIK phosphorylates IKKA dimer (Canis familiaris)
Activation of NIK (Canis familiaris)
as an output of
Activation of NIK (Canis familiaris)
Protesomal degradation of K48polyUb-TRAF3 (Canis familiaris)
as a component of
TRAF3:NIK [cytosol] (Canis familiaris)
K48polyUb-TRAF3:NIK [cytosol] (Canis familiaris)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Canis familiaris)
Other forms of this molecule
phospho-p-T559-MAP3K14 [cytosol]
K48polyUb-NIK [cytosol]
phospho-p-MAP3K14 [cytosol]
Inferred From
MAP3K14 [cytosol]
(Homo sapiens)
Active NIK [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSCAFP00845007923
,
ENSCAFG00845005731
,
ENSCAFT00845010168
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