Reactome | APOB [plasma membrane]

APOB [plasma membrane]

Stable Identifier

R-CFA-171089

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

APOB(28-4563), F1P8Z5

Locations in the PathwayBrowser

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Vesicle-mediated transport (Canis familiaris)

- Membrane Trafficking (Canis familiaris)
  - Clathrin-mediated endocytosis (Canis familiaris)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        LDL:LDLR complex [plasma membrane] (Canis familiaris)
        
        LDL [plasma membrane] (Canis familiaris)
        
        APOB [plasma membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        LDL:LDLR complex [plasma membrane] (Canis familiaris)
        
        LDL [plasma membrane] (Canis familiaris)
        
        APOB [plasma membrane] (Canis familiaris)
    - BAR domain proteins recruit dynamin (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        LDL:LDLR complex [plasma membrane] (Canis familiaris)
        
        LDL [plasma membrane] (Canis familiaris)
        
        APOB [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        LDL:LDLR complex [plasma membrane] (Canis familiaris)
        
        LDL [plasma membrane] (Canis familiaris)
        
        APOB [plasma membrane] (Canis familiaris)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Canis familiaris)
      - CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        LDL:LDLR complex [plasma membrane] (Canis familiaris)
        
        LDL [plasma membrane] (Canis familiaris)
        
        APOB [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        LDL:LDLR complex [plasma membrane] (Canis familiaris)
        
        LDL [plasma membrane] (Canis familiaris)
        
        APOB [plasma membrane] (Canis familiaris)
    - Cargo recognition for clathrin-mediated endocytosis (Canis familiaris)
      - LDLR is bound by DAB2 and ARH (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        LDL:LDLR complex [plasma membrane] (Canis familiaris)
        
        LDL [plasma membrane] (Canis familiaris)
        
        APOB [plasma membrane] (Canis familiaris)
        
        LDL:LDLR complex [plasma membrane] (Canis familiaris)
        
        LDL [plasma membrane] (Canis familiaris)
        
        APOB [plasma membrane] (Canis familiaris)
    - Clathrin recruits PIK3C2A (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        LDL:LDLR complex [plasma membrane] (Canis familiaris)
        
        LDL [plasma membrane] (Canis familiaris)
        
        APOB [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        LDL:LDLR complex [plasma membrane] (Canis familiaris)
        
        LDL [plasma membrane] (Canis familiaris)
        
        APOB [plasma membrane] (Canis familiaris)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        LDL:LDLR complex [plasma membrane] (Canis familiaris)
        
        LDL [plasma membrane] (Canis familiaris)
        
        APOB [plasma membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        LDL:LDLR complex [plasma membrane] (Canis familiaris)
        
        LDL [plasma membrane] (Canis familiaris)
        
        APOB [plasma membrane] (Canis familiaris)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        LDL:LDLR complex [plasma membrane] (Canis familiaris)
        
        LDL [plasma membrane] (Canis familiaris)
        
        APOB [plasma membrane] (Canis familiaris)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        LDL:LDLR complex [plasma membrane] (Canis familiaris)
        
        LDL [plasma membrane] (Canis familiaris)
        
        APOB [plasma membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        LDL:LDLR complex [plasma membrane] (Canis familiaris)
        
        LDL [plasma membrane] (Canis familiaris)
        
        APOB [plasma membrane] (Canis familiaris)
    - Dissociation of clathrin-associated proteins (Canis familiaris)
      - CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        LDL:LDLR complex [plasma membrane] (Canis familiaris)
        
        LDL [plasma membrane] (Canis familiaris)
        
        APOB [plasma membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        LDL:LDLR complex [plasma membrane] (Canis familiaris)
        
        LDL [plasma membrane] (Canis familiaris)
        
        APOB [plasma membrane] (Canis familiaris)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        LDL:LDLR complex [plasma membrane] (Canis familiaris)
        
        LDL [plasma membrane] (Canis familiaris)
        
        APOB [plasma membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        LDL:LDLR complex [plasma membrane] (Canis familiaris)
        
        LDL [plasma membrane] (Canis familiaris)
        
        APOB [plasma membrane] (Canis familiaris)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        LDL:LDLR complex [plasma membrane] (Canis familiaris)
        
        LDL [plasma membrane] (Canis familiaris)
        
        APOB [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        LDL:LDLR complex [plasma membrane] (Canis familiaris)
        
        LDL [plasma membrane] (Canis familiaris)
        
        APOB [plasma membrane] (Canis familiaris)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        LDL:LDLR complex [plasma membrane] (Canis familiaris)
        
        LDL [plasma membrane] (Canis familiaris)
        
        APOB [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        LDL:LDLR complex [plasma membrane] (Canis familiaris)
        
        LDL [plasma membrane] (Canis familiaris)
        
        APOB [plasma membrane] (Canis familiaris)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        LDL:LDLR complex [plasma membrane] (Canis familiaris)
        
        LDL [plasma membrane] (Canis familiaris)
        
        APOB [plasma membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        LDL:LDLR complex [plasma membrane] (Canis familiaris)
        
        LDL [plasma membrane] (Canis familiaris)
        
        APOB [plasma membrane] (Canis familiaris)
    - RAB5 and GAPVD1 bind AP-2 (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        LDL:LDLR complex [plasma membrane] (Canis familiaris)
        
        LDL [plasma membrane] (Canis familiaris)
        
        APOB [plasma membrane] (Canis familiaris)
    - SNX9 recruits components of the actin polymerizing machinery (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        LDL:LDLR complex [plasma membrane] (Canis familiaris)
        
        LDL [plasma membrane] (Canis familiaris)
        
        APOB [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        LDL:LDLR complex [plasma membrane] (Canis familiaris)
        
        LDL [plasma membrane] (Canis familiaris)
        
        APOB [plasma membrane] (Canis familiaris)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        LDL:LDLR complex [plasma membrane] (Canis familiaris)
        
        LDL [plasma membrane] (Canis familiaris)
        
        APOB [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        DAB2,LDLRAP1:LDLR:LDL [plasma membrane] (Canis familiaris)
        
        LDL:LDLR complex [plasma membrane] (Canis familiaris)
        
        LDL [plasma membrane] (Canis familiaris)
        
        APOB [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:F1P8Z5

Gene Names

APOB

Reference Genes

ENSEMBL:ENSCAFG00000003887

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000003887 APOB

Other Identifiers

475680

CfaAffx.6785.1.S1_at

CfaAffx.6785.1.S1_s_at

CfaAffx.6799.1.S1_s_at

GO:0000003

GO:0001701

GO:0003674

GO:0005319

GO:0005543

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005783

GO:0005829

GO:0006629

GO:0006642

GO:0006810

GO:0006869

GO:0007283

GO:0007399

GO:0008150

GO:0008201

GO:0008203

GO:0008289

GO:0009056

GO:0009058

GO:0009566

GO:0009615

GO:0009790

GO:0009791

GO:0010628

GO:0010744

GO:0010884

GO:0010886

GO:0015031

GO:0016042

GO:0019433

GO:0019899

GO:0030154

GO:0030301

GO:0030317

GO:0032991

GO:0033344

GO:0034359

GO:0034361

GO:0034362

GO:0034363

GO:0034374

GO:0034383

GO:0035473

GO:0040011

GO:0042157

GO:0042158

GO:0042159

GO:0042592

GO:0042627

GO:0042632

GO:0042953

GO:0043025

GO:0043167

GO:0043226

GO:0043231

GO:0044281

GO:0045540

GO:0048844

GO:0048856

GO:0048870

GO:0050750

GO:0061024

GO:0070971

GO:0120009

GO:0120020

Participates

as a component of

LDL [plasma membrane] (Canis familiaris)

Other forms of this molecule

APOB [lysosomal lumen]

APOB [clathrin-coated endocytic vesicle membrane]

APOB [endosome lumen]

APOB [endosome membrane]

APOB [endoplasmic reticulum lumen]

APOB [endoplasmic reticulum membrane]

APOB [smooth endoplasmic reticulum]

APOB [cytosol]

APOB [extracellular region]

APOB [endocytic vesicle lumen]

APOB [extracellular region]

APOB [endoplasmic reticulum lumen]

phospho-APOB [endoplasmic reticulum lumen]

APOB [extracellular region]

APOB [endocytic vesicle lumen]

Inferred From

APOB(28-4563) [plasma membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000084674

Ensembl

ENSCAFG00000003887, ENSCAFT00000006266, ENSCAFP00000005806

VGNC

37994

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