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phospho-p-S423,S425-SMAD3 [cytosol]
Stable Identifier
R-CFA-171184
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
F1PSQ3
Locations in the PathwayBrowser
Expand all
Developmental Biology (Canis familiaris)
Signaling by NODAL (Canis familiaris)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Canis familiaris)
p-2S-SMAD2,3 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Canis familiaris)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Canis familiaris)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Canis familiaris)
p-2S-SMAD2,3 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Canis familiaris)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
WWTR1:SMAD translocates to the nucleus (Canis familiaris)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-1 family signaling (Canis familiaris)
Interleukin-37 signaling (Canis familiaris)
IL37(?-218) binds p-S423,S425-SMAD3 (Canis familiaris)
IL37(?-218):p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus (Canis familiaris)
IL37(?-218):p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by TGFB family members (Canis familiaris)
Signaling by Activin (Canis familiaris)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Canis familiaris)
p-2S-SMAD2,3 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Canis familiaris)
p-2S-SMAD2,3 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
Signaling by TGF-beta Receptor Complex (Canis familiaris)
TGF-beta receptor signaling activates SMADs (Canis familiaris)
Activated type I receptor phosphorylates SMAD2/3 directly (Canis familiaris)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Canis familiaris)
p-2S-SMAD2,3 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
Downregulation of TGF-beta receptor signaling (Canis familiaris)
MTMR4 binds phosphorylated SMAD2/3 (Canis familiaris)
p-2S-SMAD2,3 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
p-2S-SMAD2/3:MTMR4 [early endosome membrane] (Canis familiaris)
p-2S-SMAD2,3 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
MTMR4 dephosphorylates SMAD2/3 (Canis familiaris)
p-2S-SMAD2/3:MTMR4 [early endosome membrane] (Canis familiaris)
p-2S-SMAD2,3 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
PMEPA1 sequesters phosphorylated SMAD2/3 (Canis familiaris)
p-2S-SMAD2,3 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
p-2S-SMAD2/3:PMEPA1 [early endosome membrane] (Canis familiaris)
p-2S-SMAD2,3 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Canis familiaris)
p-2S-SMAD2,3 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
Phosphorylated SMAD2/3 dissociates from TGFBR (Canis familiaris)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Canis familiaris)
p-2S-SMAD2,3 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
p-2S-SMAD2,3 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Canis familiaris)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Canis familiaris)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Canis familiaris)
p-2S-SMAD2,3 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Canis familiaris)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
WWTR1:SMAD translocates to the nucleus (Canis familiaris)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:F1PSQ3
Reference Genes
ENSEMBL:ENSCAFG00000017388
Participates
as an input of
IL37(?-218) binds p-S423,S425-SMAD3 (Canis familiaris)
as a component of
IL37(?-218):p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
as a member of
p-2S-SMAD2,3 [cytosol] (Canis familiaris)
Other forms of this molecule
Ub-SMAD3 [cytosol]
phospho-p-S208-SMAD3 [cytosol]
SMAD3 [nucleoplasm]
phospho-2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
phospho-Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm]
SMAD3 [cytosol]
phospho-p-S423,S425-SMAD3 [nucleoplasm]
Inferred From
p-S423,S425-SMAD3 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 423 (in Homo sapiens)
Coordinate
423
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 425 (in Homo sapiens)
Coordinate
425
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
VGNC
46520
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