Reactome | PSMC5 [nucleoplasm]

Cell Cycle (Canis familiaris)

- Cell Cycle, Mitotic (Canis familiaris)
  - Mitotic G1 phase and G1/S transition (Canis familiaris)
    - G1/S Transition (Canis familiaris)
      - Cyclin E associated events during G1/S transition (Canis familiaris)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Canis familiaris)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Canis familiaris)
        
        26S proteasome [nucleoplasm] (Canis familiaris)
        
        PSMC5 [nucleoplasm] (Canis familiaris)
  - Regulation of mitotic cell cycle (Canis familiaris)
    - APC/C-mediated degradation of cell cycle proteins (Canis familiaris)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Canis familiaris)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Canis familiaris)
        
        26S proteasome [nucleoplasm] (Canis familiaris)
        
        PSMC5 [nucleoplasm] (Canis familiaris)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Canis familiaris)
        
        Degradation of multiubiquitinated Cdh1 (Canis familiaris)
        
        26S proteasome [nucleoplasm] (Canis familiaris)
        
        PSMC5 [nucleoplasm] (Canis familiaris)
  - S Phase (Canis familiaris)
    - Cyclin A:Cdk2-associated events at S phase entry (Canis familiaris)
      - SCF(Skp2)-mediated degradation of p27/p21 (Canis familiaris)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Canis familiaris)
        
        26S proteasome [nucleoplasm] (Canis familiaris)
        
        PSMC5 [nucleoplasm] (Canis familiaris)

Cellular responses to stimuli (Canis familiaris)

- Cellular responses to stress (Canis familiaris)
  - Cellular response to chemical stress (Canis familiaris)
    - KEAP1-NFE2L2 pathway (Canis familiaris)
      - Nuclear events mediated by NFE2L2 (Canis familiaris)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Canis familiaris)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Canis familiaris)
        
        26S proteasome [nucleoplasm] (Canis familiaris)
        
        PSMC5 [nucleoplasm] (Canis familiaris)

DNA Replication (Canis familiaris)

- DNA Replication Pre-Initiation (Canis familiaris)
  - Assembly of the pre-replicative complex (Canis familiaris)
    - Ubiquitinated geminin is degraded by the proteasome (Canis familiaris)
      - 26S proteasome [nucleoplasm] (Canis familiaris)
        
        PSMC5 [nucleoplasm] (Canis familiaris)

Gene expression (Transcription) (Canis familiaris)

- RNA Polymerase II Transcription (Canis familiaris)
  - Generic Transcription Pathway (Canis familiaris)
    - Transcriptional regulation by RUNX2 (Canis familiaris)
      - Regulation of RUNX2 expression and activity (Canis familiaris)
        
        26S proteasome degrades PolyUb-RUNX2 (Canis familiaris)
        
        26S proteasome [nucleoplasm] (Canis familiaris)
        
        PSMC5 [nucleoplasm] (Canis familiaris)
    - Transcriptional regulation by RUNX3 (Canis familiaris)
      - Regulation of RUNX3 expression and activity (Canis familiaris)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Canis familiaris)
        
        26S proteasome [nucleoplasm] (Canis familiaris)
        
        PSMC5 [nucleoplasm] (Canis familiaris)

Metabolism of proteins (Canis familiaris)

- Post-translational protein modification (Canis familiaris)
  - Deubiquitination (Canis familiaris)
    - Ub-specific processing proteases (Canis familiaris)
      - USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Canis familiaris)
        
        USP37:RUVLB1:PSMC5:CCNA1,CCNA2 [nucleoplasm] (Canis familiaris)
        
        USP37:RUVLB1:PSMC5 [nucleoplasm] (Canis familiaris)
        
        PSMC5 [nucleoplasm] (Canis familiaris)
        
        USP37:RUVLB1:PSMC5:PolyUb-CCNA1,PolyUb-CCNA2 [nucleoplasm] (Canis familiaris)
        
        USP37:RUVLB1:PSMC5 [nucleoplasm] (Canis familiaris)
        
        PSMC5 [nucleoplasm] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Signaling by Hedgehog (Canis familiaris)
  - Hedgehog 'on' state (Canis familiaris)
    - GLI2,3 are degraded by the proteasome (Canis familiaris)
      - 26S proteasome [nucleoplasm] (Canis familiaris)
        
        PSMC5 [nucleoplasm] (Canis familiaris)