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About
What is Reactome ?
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HIST1H4 [nucleoplasm]
Stable Identifier
R-CFA-181902
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
nucleoplasm
Synonyms
F2Z4N2
Locations in the PathwayBrowser
Expand all
Cell Cycle (Canis familiaris)
Cell Cycle, Mitotic (Canis familiaris)
M Phase (Canis familiaris)
Mitotic Prophase (Canis familiaris)
Condensation of Prophase Chromosomes (Canis familiaris)
PHF8 demethylates histone H4K20me1 (Canis familiaris)
PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Canis familiaris)
Nucleosome with H3K4me2/3 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
SETD8 monomethylates histone H4 (Canis familiaris)
PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Canis familiaris)
Nucleosome with H3K4me2/3 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
Chromosome Maintenance (Canis familiaris)
Nucleosome assembly (Canis familiaris)
Deposition of new CENPA-containing nucleosomes at the centromere (Canis familiaris)
HJURP:CENPA complex localizes to the centromere (Canis familiaris)
CCAN:DNA:CASC5:Mis18 complex:HJURP complex:CENPA:H4 [nucleoplasm] (Canis familiaris)
HJURP:NPM1:RBBP4:RBBP7:RUVBL1:CENPA:H4 [nucleoplasm] (Canis familiaris)
CENPA:H4 Tetramer [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
HJURP:NPM1:RBBP4:RBBP7:RUVBL1:CENPA:H4 [nucleoplasm] (Canis familiaris)
CENPA:H4 Tetramer [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
New CENPA-containing nucleosomes are deposited at the centromere (Canis familiaris)
CCAN:DNA:CASC5:Mis18 complex:HJURP complex:CENPA nucleosome [nucleoplasm] (Canis familiaris)
Centromeric Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
CCAN:DNA:CASC5:Mis18 complex:HJURP complex:CENPA:H4 [nucleoplasm] (Canis familiaris)
HJURP:NPM1:RBBP4:RBBP7:RUVBL1:CENPA:H4 [nucleoplasm] (Canis familiaris)
CENPA:H4 Tetramer [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
RSF complex binds the centromere (Canis familiaris)
CCAN:DNA:CASC5:Centromeric nucleosome:RSF complex [nucleoplasm] (Canis familiaris)
Centromeric Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
CCAN:DNA:CASC5:Mis18 complex:HJURP complex:CENPA nucleosome [nucleoplasm] (Canis familiaris)
Centromeric Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
Telomere Maintenance (Canis familiaris)
Packaging Of Telomere Ends (Canis familiaris)
Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Canis familiaris)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex [nucleoplasm] (Canis familiaris)
Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Canis familiaris)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Canis familiaris)
Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
Cellular responses to external stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular Senescence (Canis familiaris)
DNA Damage/Telomere Stress Induced Senescence (Canis familiaris)
Telomere shortening during replicative exhaustion (Canis familiaris)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Canis familiaris)
Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
Oxidative Stress Induced Senescence (Canis familiaris)
KDM6B demethylates H3K27me3 on p16INK4A promoter (Canis familiaris)
CDKN2A Gene:H3K27Me3-Nucleosome [nucleoplasm] (Canis familiaris)
Nucleosome with H3K27me3 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
CDKN2A Gene:Nucleosome [nucleoplasm] (Canis familiaris)
Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Canis familiaris)
CDKN2A Gene:H3K27Me3-Nucleosome [nucleoplasm] (Canis familiaris)
Nucleosome with H3K27me3 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Canis familiaris)
CDKN2A Gene:H3K27Me3-Nucleosome [nucleoplasm] (Canis familiaris)
Nucleosome with H3K27me3 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Canis familiaris)
CDKN2A Gene:H3K27Me3-Nucleosome [nucleoplasm] (Canis familiaris)
Nucleosome with H3K27me3 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
CDKN2A Gene:Nucleosome [nucleoplasm] (Canis familiaris)
Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
p-MAPKAPK3 phosphorylates BMI1 (Canis familiaris)
CDKN2A Gene:H3K27Me3-Nucleosome [nucleoplasm] (Canis familiaris)
Nucleosome with H3K27me3 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Canis familiaris)
CDKN2A Gene:H3K27Me3-Nucleosome [nucleoplasm] (Canis familiaris)
Nucleosome with H3K27me3 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
Senescence-Associated Secretory Phenotype (SASP) (Canis familiaris)
EHMT1:EHMT2 methylates IL6 promoter (Canis familiaris)
IL6 gene:Nucleosome [nucleoplasm] (Canis familiaris)
Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
IL6 gene:Nucleosome-H3K9Me2 [nucleoplasm] (Canis familiaris)
Nucleosome with H3K9me2 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
EHMT1:EHMT2 methylates IL8 promoter (Canis familiaris)
IL8 gene:Nucleosome [nucleoplasm] (Canis familiaris)
Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
IL8 gene:Nucleosome-H3K9Me2 [nucleoplasm] (Canis familiaris)
Nucleosome with H3K9me2 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
Chromatin organization (Canis familiaris)
Chromatin modifying enzymes (Canis familiaris)
HATs acetylate histones (Canis familiaris)
ATF2 acetylates histone H2B, H4 (Canis familiaris)
Histone H2B, H4 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
EP300 acetylates histone H2A, H2B, H3, H4 (Canis familiaris)
Histone H2A, H2B, H3, H4 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
MSL acetylates histone H4 (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
NSL acetylates histone H4 (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
Type B histone acetlytransferase complex acetylates histone H4 (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
HDACs deacetylate histones (Canis familiaris)
HDAC1/2 containing-complexes deacetylate histones (Canis familiaris)
Core histone octamer [nucleoplasm] (Canis familiaris)
Histone H3:H4 tetramer [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
HDAC10 deacetylates histone (Canis familiaris)
Core histone octamer [nucleoplasm] (Canis familiaris)
Histone H3:H4 tetramer [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
HDAC3 containing complexes deacetylate histone (Canis familiaris)
Core histone octamer [nucleoplasm] (Canis familiaris)
Histone H3:H4 tetramer [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
HDAC8 deacetylates histones (Canis familiaris)
Core histone octamer [nucleoplasm] (Canis familiaris)
Histone H3:H4 tetramer [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
HDMs demethylate histones (Canis familiaris)
JMJD6 demethylates MeR4-HIST1H4 (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
PHF8 demethylates MeK21-histone H4 (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
PKMTs methylate histone lysines (Canis familiaris)
SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
RMTs methylate histone arginines (Canis familiaris)
COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Canis familiaris)
MeR4-HIST1H4, HIST1H4 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
PRMT1,PRMT6 methylate arginine-4 of histone H4 (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
DNA Repair (Canis familiaris)
Base Excision Repair (Canis familiaris)
Base-Excision Repair, AP Site Formation (Canis familiaris)
Depurination (Canis familiaris)
Cleavage of the damaged purine (Canis familiaris)
NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Canis familiaris)
NEIL3:AP-Telomeric DNA:Shelterin [nucleoplasm] (Canis familiaris)
AP-Telomeric DNA:Shelterin [nucleoplasm] (Canis familiaris)
Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
NEIL3:Gh-Telomeric DNA:Shelterin [nucleoplasm] (Canis familiaris)
Gh-Telomeric DNA:Shelterin [nucleoplasm] (Canis familiaris)
Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
Recognition and association of DNA glycosylase with site containing an affected purine (Canis familiaris)
NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Canis familiaris)
Gh-Telomeric DNA:Shelterin [nucleoplasm] (Canis familiaris)
Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
NEIL3:Gh-Telomeric DNA:Shelterin [nucleoplasm] (Canis familiaris)
Gh-Telomeric DNA:Shelterin [nucleoplasm] (Canis familiaris)
Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
DNA Double-Strand Break Repair (Canis familiaris)
DNA Double Strand Break Response (Canis familiaris)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Canis familiaris)
APBB1 and MAPK8 bind diphosphorylated H2AFX (Canis familiaris)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome:APBB1:p-T,Y-MAPK8 [nucleoplasm] (Canis familiaris)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
ATM phosphorylates EYA1-4 (Canis familiaris)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
ATM phosphorylates MDC1 (Canis familiaris)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:MDC1 [nucleoplasm] (Canis familiaris)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Canis familiaris)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
ATM phosphorylates WHSC1 (Canis familiaris)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:WHSC1 [nucleoplasm] (Canis familiaris)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Canis familiaris)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Canis familiaris)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Canis familiaris)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Canis familiaris)
DNA DSBs:p-MRN:p-S-1981,Ac-K3016-ATM:KAT5:p-Y142-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
p-Y142-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
ATM recognizes H2AFX-Nucleosomes (Canis familiaris)
DNA DSBs:p-MRN:p-S-1981,Ac-K3016-ATM:KAT5:p-Y142-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
p-Y142-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
p-Y142-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Canis familiaris)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
MDC1 associates with gamma-H2AFX at nuclear foci (Canis familiaris)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:MDC1 [nucleoplasm] (Canis familiaris)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
WHSC1 binds DNA DSBs (Canis familiaris)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Canis familiaris)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:WHSC1 [nucleoplasm] (Canis familiaris)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Canis familiaris)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Canis familiaris)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Canis familiaris)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Canis familiaris)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
WICH phosphorylates H2AFX on Y142 (Canis familiaris)
H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
p-Y142-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
Gene expression (Transcription) (Canis familiaris)
Epigenetic regulation of gene expression (Canis familiaris)
Negative epigenetic regulation of rRNA expression (Canis familiaris)
NoRC negatively regulates rRNA expression (Canis familiaris)
MBD2 binds methylcytosine in chromatin (Canis familiaris)
Chromatin (H3K9me2, 5mC):MBD2 [nucleoplasm] (Canis familiaris)
Chromatin with H3K9me2, 5mC [nucleoplasm] (Canis familiaris)
Nucleosome with H3K9me2 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
Chromatin with H3K9me2, 5mC [nucleoplasm] (Canis familiaris)
Nucleosome with H3K9me2 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
SIRT1 negatively regulates rRNA expression (Canis familiaris)
Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Canis familiaris)
Chromatin (H3K9me2) [nucleoplasm] (Canis familiaris)
Nucleosome with H3K9me2 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
eNoSC [nucleoplasm] (Canis familiaris)
Chromatin (H3K9me2) [nucleoplasm] (Canis familiaris)
Nucleosome with H3K9me2 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
eNoSC deacetylates histone H3 (Canis familiaris)
Chromatin [nucleoplasm] (Canis familiaris)
Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
Chromatin with acetylated H3 [nucleoplasm] (Canis familiaris)
Nucleosome (H3K9ac, H3K14ac) [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
eNoSC [nucleoplasm] (Canis familiaris)
Chromatin (H3K9me2) [nucleoplasm] (Canis familiaris)
Nucleosome with H3K9me2 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
eNoSC dimethylates histone H3 at lysine-9 (Canis familiaris)
Chromatin (H3K9me2) [nucleoplasm] (Canis familiaris)
Nucleosome with H3K9me2 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
Chromatin [nucleoplasm] (Canis familiaris)
Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
eNoSC [nucleoplasm] (Canis familiaris)
Chromatin (H3K9me2) [nucleoplasm] (Canis familiaris)
Nucleosome with H3K9me2 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
PRC2 methylates histones and DNA (Canis familiaris)
DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Canis familiaris)
DNMT1,3A,3B:PRC2:Chromatin (5-mC, H3K27me3) [nucleoplasm] (Canis familiaris)
PRC2:Chromatin (5-methylcytosine, H3K27me3) [nucleoplasm] (Canis familiaris)
Chromatin with hemimethylC, H3K27me3 [nucleoplasm] (Canis familiaris)
Nucleosome with H3K27me3 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
DNMT1,3A,3B:PRC2:Chromatin [nucleoplasm] (Canis familiaris)
PRC2 Core:Chromatin [nucleoplasm] (Canis familiaris)
Chromatin [nucleoplasm] (Canis familiaris)
Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
PRC2 recruits DNA methyltransferases (Canis familiaris)
DNMT1,3A,3B:PRC2:Chromatin [nucleoplasm] (Canis familiaris)
PRC2 Core:Chromatin [nucleoplasm] (Canis familiaris)
Chromatin [nucleoplasm] (Canis familiaris)
Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
PRC2 Core:Chromatin [nucleoplasm] (Canis familiaris)
Chromatin [nucleoplasm] (Canis familiaris)
Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
PRC2 trimethylates histone H3 at lysine-27 (Canis familiaris)
PRC2:Chromatin (H3K27me3) [nucleoplasm] (Canis familiaris)
Chromatin with trimethylated H3K27 [nucleoplasm] (Canis familiaris)
Nucleosome with H3K27me3 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
PRC2:Chromatin [nucleoplasm] (Canis familiaris)
Chromatin [nucleoplasm] (Canis familiaris)
Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Canis familiaris)
Chromatin [nucleoplasm] (Canis familiaris)
Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
PRC2:Chromatin [nucleoplasm] (Canis familiaris)
Chromatin [nucleoplasm] (Canis familiaris)
Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
Positive epigenetic regulation of rRNA expression (Canis familiaris)
B-WICH complex positively regulates rRNA expression (Canis familiaris)
B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Canis familiaris)
Nucleosome (H3K9ac) [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
Gene Silencing by RNA (Canis familiaris)
Transcriptional regulation by small RNAs (Canis familiaris)
AGO1,2:small RNA complexes interact with chromatin (Canis familiaris)
AGO1,2:miRNA:chromatin:RNA pol II [nucleoplasm] (Canis familiaris)
Chromatin [nucleoplasm] (Canis familiaris)
Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
Chromatin [nucleoplasm] (Canis familiaris)
Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
RNA Polymerase I Transcription (Canis familiaris)
RNA Polymerase I Promoter Clearance (Canis familiaris)
RNA Polymerase I Promoter Escape (Canis familiaris)
Elongation of pre-rRNA transcript (Canis familiaris)
Chromatin (H3K9me2):CBX3 [nucleoplasm] (Canis familiaris)
Chromatin (H3K9me2) [nucleoplasm] (Canis familiaris)
Nucleosome with H3K9me2 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
RNA Polymerase I Promoter Opening (Canis familiaris)
UBF-1 Binds rDNA Promoter (Canis familiaris)
Chromatin (H3K9me2, 5mC):MBD2 [nucleoplasm] (Canis familiaris)
Chromatin with H3K9me2, 5mC [nucleoplasm] (Canis familiaris)
Nucleosome with H3K9me2 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional regulation by RUNX1 (Canis familiaris)
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Canis familiaris)
Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Canis familiaris)
H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
Nucleosome with H3K4me2 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
Nucleosome with H3K4me3 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Canis familiaris)
H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
Nucleosome with H3K4me2 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
Nucleosome with H3K4me3 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Canis familiaris)
H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
Nucleosome with H3K4me2 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
Nucleosome with H3K4me3 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Canis familiaris)
H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
Nucleosome with H3K4me2 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
Nucleosome with H3K4me3 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Canis familiaris)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Canis familiaris)
Nucleosome with H3K4me2 and H3R2me2a [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2-Nucleosome [nucleoplasm] (Canis familiaris)
Nucleosome with H3K4me2 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Canis familiaris)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Canis familiaris)
Nucleosome with H3K4me2 and H3R2me2a [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2-Nucleosome [nucleoplasm] (Canis familiaris)
Nucleosome with H3K4me2 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Canis familiaris)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Canis familiaris)
Nucleosome with H3K4me2 and H3R2me2a [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2-Nucleosome [nucleoplasm] (Canis familiaris)
Nucleosome with H3K4me2 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Canis familiaris)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1 gene:H3K4me2-Nucleosome [nucleoplasm] (Canis familiaris)
Nucleosome with H3K4me2 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Canis familiaris)
Nucleosome with H3K4me2 and H3R2me2a [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
SUMOylation (Canis familiaris)
SUMO E3 ligases SUMOylate target proteins (Canis familiaris)
SUMOylation of chromatin organization proteins (Canis familiaris)
SUMOylation of Histone H4 with SUMO1 (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
SUMOylation of Histone H4 with SUMO3 (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by Nuclear Receptors (Canis familiaris)
ESR-mediated signaling (Canis familiaris)
Estrogen-dependent gene expression (Canis familiaris)
Binding of AP1 transcriptional activator complexes to CCND1 promoter (Canis familiaris)
CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3 [nucleoplasm] (Canis familiaris)
Nucleosome with H3K4me2 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3:ESTG:ESR1 dimer:JUN:ATF2:POUF21:ESTG:ESR1 dimer:JUN:FOS [nucleoplasm] (Canis familiaris)
CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3 [nucleoplasm] (Canis familiaris)
Nucleosome with H3K4me2 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
EP300 is recruited to MYC and BCL2 genes (Canis familiaris)
MYC gene, BCL2 gene:HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Canis familiaris)
HIST1H2AC nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
MYC gene, BCL2 gene:HIST1H2AC nuclesome:ESR1:ESTG:EP300 [nucleoplasm] (Canis familiaris)
MYC gene, BCL2 gene:HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Canis familiaris)
HIST1H2AC nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Canis familiaris)
KDM4B-regulated genes:H3K9me3 nucleosome [nucleoplasm] (Canis familiaris)
Nucleosome with H3K9me3 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
KDM4B-regulated genes:H3K9me3 nucleosome:ESR1:ESTG:KDM4B [nucleoplasm] (Canis familiaris)
KDM4B-regulated genes:H3K9me3 nucleosome [nucleoplasm] (Canis familiaris)
Nucleosome with H3K9me3 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
FOXA1 and GATA3 bind to CCND1 promoter (Canis familiaris)
CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3 [nucleoplasm] (Canis familiaris)
Nucleosome with H3K4me2 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
CCND1 gene:H3K4me2 nucleosome:YY1:HDAC1 [nucleoplasm] (Canis familiaris)
Nucleosome with H3K4me2 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Canis familiaris)
MYC gene, BCL2 gene: H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG:KDM1A [nucleoplasm] (Canis familiaris)
MYC gene, BLC2 gene:H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Canis familiaris)
Nucleosome with H3K9me2 and HIST1H2AC: [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
MYC gene, BCL2 gene:HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Canis familiaris)
HIST1H2AC nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
KDM1A is recruited to MYC and BCL2 genes (Canis familiaris)
MYC gene, BCL2 gene: H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG:KDM1A [nucleoplasm] (Canis familiaris)
MYC gene, BLC2 gene:H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Canis familiaris)
Nucleosome with H3K9me2 and HIST1H2AC: [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
MYC gene, BLC2 gene:H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Canis familiaris)
Nucleosome with H3K9me2 and HIST1H2AC: [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Canis familiaris)
KDM4B-regulated genes:H3K9me3 nucleosome:ESR1:ESTG:KDM4B [nucleoplasm] (Canis familiaris)
KDM4B-regulated genes:H3K9me3 nucleosome [nucleoplasm] (Canis familiaris)
Nucleosome with H3K9me3 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
KDM4B-regulated genes:nucleosome:ESR1:ESTG [nucleoplasm] (Canis familiaris)
Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Canis familiaris)
GREB1 gene:nucleosome:ESR1:ESTG [nucleoplasm] (Canis familiaris)
Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
GREB1 gene:nucleosome:ESR1:ESTG:ZNF217:NCOA3:NR5A2 [nucleoplasm] (Canis familiaris)
GREB1 gene:nucleosome:ESR1:ESTG [nucleoplasm] (Canis familiaris)
Nucleosome [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Canis familiaris)
MYC gene, BCL2 gene: H3K9me2 nucleosome [nucleoplasm] (Canis familiaris)
Nucleosome with H3K9me2 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
MYC gene, BLC2 gene:H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Canis familiaris)
Nucleosome with H3K9me2 and HIST1H2AC: [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase Effectors (Canis familiaris)
RHO GTPases activate PKNs (Canis familiaris)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Canis familiaris)
Demethylase KDM1A binds KLK2 and KLK3 promoters (Canis familiaris)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 [nucleoplasm] (Canis familiaris)
Nucleosome with p-T12, Me2K-10-H3 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm] (Canis familiaris)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 [nucleoplasm] (Canis familiaris)
Nucleosome with p-T12, Me2K-10-H3 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
Demethylase KDM4C binds KLK2 and KLK3 promoters (Canis familiaris)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C [nucleoplasm] (Canis familiaris)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm] (Canis familiaris)
KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Canis familiaris)
Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm] (Canis familiaris)
KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Canis familiaris)
Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Canis familiaris)
p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A [nucleoplasm] (Canis familiaris)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 [nucleoplasm] (Canis familiaris)
Nucleosome with p-T12, Me2K-10-H3 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,MeK-10-H3:KDM1A [nucleoplasm] (Canis familiaris)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,MeK-10-H3 [nucleoplasm] (Canis familiaris)
Nucleosome with p-T12, MeK-10-H3 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Canis familiaris)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-H3 [nucleoplasm] (Canis familiaris)
Nucleosome with p-T12-H3 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,MeK-10-H3:KDM1A [nucleoplasm] (Canis familiaris)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,MeK-10-H3 [nucleoplasm] (Canis familiaris)
Nucleosome with p-T12, MeK-10-H3 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Canis familiaris)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C [nucleoplasm] (Canis familiaris)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm] (Canis familiaris)
KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Canis familiaris)
Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3 [nucleoplasm] (Canis familiaris)
Nucleosome with p-T12, Me2K-10-H3 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Canis familiaris)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Canis familiaris)
KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Canis familiaris)
Nucleosome with H3K9me3 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm] (Canis familiaris)
KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Canis familiaris)
Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Canis familiaris)
KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Canis familiaris)
Nucleosome with H3K9me3 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Canis familiaris)
KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Canis familiaris)
Nucleosome with H3K9me3 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
Signaling by WNT (Canis familiaris)
TCF dependent signaling in response to WNT (Canis familiaris)
Formation of the beta-catenin:TCF transactivating complex (Canis familiaris)
SET1 complex trimethylates H3K4 at the MYC gene (Canis familiaris)
MYC gene: H2B K121ub nucleosome [nucleoplasm] (Canis familiaris)
Nucleosome with H2BK121ub [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
MYC gene:H2B K121ub H3K4me3 nucleosome [nucleoplasm] (Canis familiaris)
Nucleosome with H2BK121ub and H3K4me3 [nucleoplasm] (Canis familiaris)
HIST1H4 [nucleoplasm] (Canis familiaris)
External Reference Information
External Reference
UniProt:F2Z4N2
Reference Genes
BioGPS Gene:106558236
BioGPS Gene:486670
BioGPS Gene:488277
ENSEMBL:ENSCAFG00000012989
ENSEMBL:ENSCAFG00000024573
ENSEMBL:ENSCAFG00000029032
ENSEMBL:ENSCAFG00000029066
ENSEMBL:ENSCAFG00000029110
ENSEMBL:ENSCAFG00000029986
ENSEMBL:ENSCAFG00000030696
ENSEMBL:ENSCAFG00000030825
ENSEMBL:ENSCAFG00000031940
ENSEMBL:ENSCAFG00000032188
KEGG Gene (Canis familiaris):106558236
KEGG Gene (Canis familiaris):486670
KEGG Gene (Canis familiaris):488277
Monarch:106558236
Monarch:486670
Monarch:488277
NCBI Gene:106558236
NCBI Gene:486670
NCBI Gene:488277
Reference Transcript
RefSeq:XM_014110521.1
RefSeq:XM_543797.4
RefSeq:XM_014110638.1
Other Identifiers
100856216
106558236
111093990
483167
486670
488277
AAEX03011043
AAEX03015240
AAEX03017606
AAEX03017607
AAEX03017610
AAEX03017613
CfaAffx.17923.1.S1_at
CfaAffx.20105.1.S1_at
CfaAffx.251.1.S1_s_at
ENSCAFG00000012989
ENSCAFG00000024573
ENSCAFG00000029032
ENSCAFG00000029066
ENSCAFG00000029110
ENSCAFG00000029986
ENSCAFG00000030696
ENSCAFG00000030825
ENSCAFG00000031940
ENSCAFG00000032188
ENSCAFP00000019126
ENSCAFP00000033563
ENSCAFP00000034229
ENSCAFP00000036545
ENSCAFP00000037324
ENSCAFP00000037435
ENSCAFP00000038752
ENSCAFP00000040694
ENSCAFP00000042617
ENSCAFP00000043106
ENSCAFT00000020608
ENSCAFT00000037917
ENSCAFT00000038497
ENSCAFT00000043028
ENSCAFT00000043700
ENSCAFT00000043841
ENSCAFT00000045413
ENSCAFT00000046795
ENSCAFT00000048693
ENSCAFT00000049127
EntrezGene:100856216
EntrezGene:106558236
EntrezGene:111093990
EntrezGene:483167
EntrezGene:486670
EntrezGene:488277
EntrezGene:LOC100856216
EntrezGene:LOC106558236
EntrezGene:LOC111093990
EntrezGene:LOC483167
EntrezGene:LOC486670
EntrezGene:LOC488277
GO:0000786
GO:0003674
GO:0003677
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005694
GO:0006334
GO:0006352
GO:0008150
GO:0009058
GO:0022607
GO:0032991
GO:0034641
GO:0043226
GO:0046982
GO:0051276
GO:0065003
IPR001951
IPR004823
IPR009072
IPR019809
IPR035425
LOC100856216
LOC106558236
LOC111093990
LOC483167
LOC486670
LOC488277
PF15511
PR00623
SM00417
SM00803
UPI000000003C
XM_003639614
XM_003640164
XM_005640100
XM_543797
XP_003639662
XP_003640212
XP_005640157
XP_013965996
XP_013966113
XP_022260662
XP_022270160
XP_022270161
XP_543797
Participant Of
hasComponent
CENPA:H4 Tetramer [nucleoplasm]
Centromeric Nucleosome [nucleoplasm]
H2AFX-Nucleosome [nucleoplasm]
HIST1H2AC nucleosome [nucleoplasm]
Histone H3:H4 tetramer [nucleoplasm]
Nucleosome (H3K9ac) [nucleoplasm]
Nucleosome (H3K9ac, H3K14ac) [nucleoplasm]
Nucleosome [nucleoplasm]
Nucleosome [nucleoplasm]
Nucleosome with H2BK121ub [nucleoplasm]
Nucleosome with H2BK121ub and H3K4me3 [nucleoplasm]
Nucleosome with H3K27me3 [nucleoplasm]
Nucleosome with H3K4me2 [nucleoplasm]
Nucleosome with H3K4me2 and H3R2me2a [nucleoplasm]
Nucleosome with H3K4me2/3 [nucleoplasm]
Nucleosome with H3K4me3 [nucleoplasm]
Nucleosome with H3K9me2 [nucleoplasm]
Nucleosome with H3K9me2 and HIST1H2AC: [nucleoplasm]
Nucleosome with H3K9me3 [nucleoplasm]
Nucleosome with p-T12, Me2K-10-H3 [nucleoplasm]
Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm]
Nucleosome with p-T12, MeK-10-H3 [nucleoplasm]
Nucleosome with p-T12-H3 [nucleoplasm]
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm]
p-S139-H2AFX-Nucleosome [nucleoplasm]
p-Y142-H2AFX-Nucleosome [nucleoplasm]
input
MSL acetylates histone H4
NSL acetylates histone H4
PRMT1,PRMT6 methylate arginine-4 of histone H4
SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20)
SUMOylation of Histone H4 with SUMO1
SUMOylation of Histone H4 with SUMO3
Type B histone acetlytransferase complex acetylates histone H4
hasMember
Histone H2B, H4 [nucleoplasm]
hasCandidate
Histone H2A, H2B, H3, H4 [nucleoplasm]
MeR4-HIST1H4, HIST1H4 [nucleoplasm]
output
JMJD6 demethylates MeR4-HIST1H4
PHF8 demethylates MeK21-histone H4
Other forms of this molecule
SUMO3-HIST1H4 [nucleoplasm]
SUMO1-HIST1H4 [nucleoplasm]
AcK5,12-HIST1H4A [nucleoplasm]
AcK13-HIST1H4 [nucleoplasm]
AcK6-HIST1H4 [nucleoplasm]
AcK17-HIST1H4 [nucleoplasm]
Me2K21-HIST1H4 [nucleoplasm]
MeK-HIST1H4A [nucleoplasm]
AcK-HIST1H4 [nucleoplasm]
Me3K21-HIST1H4 [nucleoplasm]
MeR4-HIST1H4 [nucleoplasm]
Me2sR4-HIST1H4 [nucleoplasm]
Me2aR4-HIST1H4 [nucleoplasm]
AcK9-HIST1H4 [nucleoplasm]
Inferred From
HIST1H4 [nucleoplasm] (Homo sapiens)
Cross References
RefSeq
XP_543797.2
,
XP_013965996.1
,
XP_013966113.1
© 2019
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