Reactome | H4-16 [nucleoplasm]

H4-16 [nucleoplasm]

Stable Identifier

R-CFA-181902

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

HIST1H4, F2Z4N2

Locations in the PathwayBrowser

Expand all

DNA Repair (Canis familiaris)

- Base Excision Repair (Canis familiaris)
  - Base-Excision Repair, AP Site Formation (Canis familiaris)
    - Depurination (Canis familiaris)
      - Cleavage of the damaged purine (Canis familiaris)
        
        NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Canis familiaris)
        
        NEIL3:AP-Telomeric DNA:Shelterin [nucleoplasm] (Canis familiaris)
        
        AP-Telomeric DNA:Shelterin [nucleoplasm] (Canis familiaris)
        
        Nucleosome [nucleoplasm] (Canis familiaris)
        
        H4-16 [nucleoplasm] (Canis familiaris)
        
        NEIL3:Gh-Telomeric DNA:Shelterin [nucleoplasm] (Canis familiaris)
        
        Gh-Telomeric DNA:Shelterin [nucleoplasm] (Canis familiaris)
        
        Nucleosome [nucleoplasm] (Canis familiaris)
        
        H4-16 [nucleoplasm] (Canis familiaris)
      - Recognition and association of DNA glycosylase with site containing an affected purine (Canis familiaris)
        
        NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Canis familiaris)
        
        Gh-Telomeric DNA:Shelterin [nucleoplasm] (Canis familiaris)
        
        Nucleosome [nucleoplasm] (Canis familiaris)
        
        H4-16 [nucleoplasm] (Canis familiaris)
        
        NEIL3:Gh-Telomeric DNA:Shelterin [nucleoplasm] (Canis familiaris)
        
        Gh-Telomeric DNA:Shelterin [nucleoplasm] (Canis familiaris)
        
        Nucleosome [nucleoplasm] (Canis familiaris)
        
        H4-16 [nucleoplasm] (Canis familiaris)
- DNA Double-Strand Break Repair (Canis familiaris)
  - DNA Double Strand Break Response (Canis familiaris)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Canis familiaris)
      - APBB1 and MAPK8 bind diphosphorylated H2AFX (Canis familiaris)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        H4-16 [nucleoplasm] (Canis familiaris)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome:APBB1:p-T,Y-MAPK8 [nucleoplasm] (Canis familiaris)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        H4-16 [nucleoplasm] (Canis familiaris)
      - ATM phosphorylates EYA1-4 (Canis familiaris)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        H4-16 [nucleoplasm] (Canis familiaris)
      - ATM phosphorylates MDC1 (Canis familiaris)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:MDC1 [nucleoplasm] (Canis familiaris)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        H4-16 [nucleoplasm] (Canis familiaris)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Canis familiaris)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        H4-16 [nucleoplasm] (Canis familiaris)
      - ATM phosphorylates WHSC1 (Canis familiaris)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:WHSC1 [nucleoplasm] (Canis familiaris)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Canis familiaris)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        H4-16 [nucleoplasm] (Canis familiaris)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Canis familiaris)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Canis familiaris)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        H4-16 [nucleoplasm] (Canis familiaris)
      - ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Canis familiaris)
        
        DNA DSBs:p-MRN:p-S-1981,Ac-K3016-ATM:KAT5:p-Y142-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        p-Y142-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        H4-16 [nucleoplasm] (Canis familiaris)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        H4-16 [nucleoplasm] (Canis familiaris)
      - ATM recognizes H2AFX-Nucleosomes (Canis familiaris)
        
        DNA DSBs:p-MRN:p-S-1981,Ac-K3016-ATM:KAT5:p-Y142-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        p-Y142-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        H4-16 [nucleoplasm] (Canis familiaris)
        
        p-Y142-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        H4-16 [nucleoplasm] (Canis familiaris)
      - EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Canis familiaris)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        H4-16 [nucleoplasm] (Canis familiaris)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        H4-16 [nucleoplasm] (Canis familiaris)
      - MDC1 associates with gamma-H2AFX at nuclear foci (Canis familiaris)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        H4-16 [nucleoplasm] (Canis familiaris)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:MDC1 [nucleoplasm] (Canis familiaris)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        H4-16 [nucleoplasm] (Canis familiaris)
      - WHSC1 binds DNA DSBs (Canis familiaris)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Canis familiaris)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        H4-16 [nucleoplasm] (Canis familiaris)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:WHSC1 [nucleoplasm] (Canis familiaris)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Canis familiaris)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        H4-16 [nucleoplasm] (Canis familiaris)
      - WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Canis familiaris)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Canis familiaris)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Canis familiaris)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        p-S139-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        H4-16 [nucleoplasm] (Canis familiaris)
      - WICH phosphorylates H2AFX on Y142 (Canis familiaris)
        
        H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        H4-16 [nucleoplasm] (Canis familiaris)
        
        p-Y142-H2AFX-Nucleosome [nucleoplasm] (Canis familiaris)
        
        H4-16 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:F2Z4N2

Gene Names

H4-16

Reference Genes

BioGPS Gene:106558236 H4-16

BioGPS Gene:486670 H4-16

BioGPS Gene:488277 H4-16

ENSEMBL:ENSCAFG00000012989

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000012989 H4-16

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000024573 H4-16

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000029032 H4-16

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000029066 H4-16

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000029110 H4-16

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000029986 H4-16

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000030696 H4-16

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000030825 H4-16

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000031940 H4-16

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000032188 H4-16

KEGG Gene (Canis familiaris):106558236 H4-16

KEGG Gene (Canis familiaris):486670 H4-16

KEGG Gene (Canis familiaris):488277 H4-16

Monarch:106558236 H4-16

Monarch:486670 H4-16

Monarch:488277 H4-16

NCBI Gene:106558236 H4-16

NCBI Gene:486670 H4-16

NCBI Gene:488277 H4-16

Reference Transcript

Other Identifiers

100856160

100856216

106558236

111093990

115945199

483167

486670

488277

488306

CfaAffx.17923.1.S1_at

CfaAffx.20105.1.S1_at

CfaAffx.251.1.S1_s_at

GO:0000228

GO:0000786

GO:0000788

GO:0002376

GO:0003674

GO:0003677

GO:0005575

GO:0005622

GO:0005634

GO:0005694

GO:0006334

GO:0006335

GO:0006336

GO:0006352

GO:0008150

GO:0009058

GO:0019904

GO:0022607

GO:0030154

GO:0032991

GO:0034641

GO:0042025

GO:0043226

GO:0045653

GO:0046982

GO:0048856

GO:0051276

GO:0065003

Participant Of

hasComponent

input

hasMember

Histone H2B, H4 [nucleoplasm]

hasCandidate

output

Other forms of this molecule

H4-16 [nucleoplasm]

Inferred From

HIST1H4 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_543797.2, XP_013966113.1, XP_013965996.1

Target Pathogen

57cdcfc3be737e0b49b99526, 5b2801b3be737e35a6df0fcf, 5b354852be737e166372ec9f, 5b2801b3be737e35a6dee563, 5b2801b3be737e35a6deea7e, 57c08402be737e1cc0a93fd8, 5b2801b2be737e35a6de88ac, 57c08401be737e1cc0a93fd1, 5b2801b2be737e35a6deb951, 5b2801b2be737e35a6dea281, 5b2801b3be737e35a6df0c8e, 57c5e2c5be737e5a0cb4a390, 57c08402be737e1cc0a93fda, 5b2801b2be737e35a6deac02, 5b2801b2be737e35a6de9486

OpenTargets

ENSG00000197837

Ensembl

ENSCAFP00000036545, ENSCAFT00000037917, ENSCAFT00000049127, ENSCAFT00000048693, ENSCAFT00000020608, ENSCAFP00000037435, ENSCAFG00000029110, ENSCAFP00000042617, ENSCAFP00000040694, ENSCAFP00000043106, ENSCAFT00000046795, ENSCAFG00000024573, ENSCAFT00000038497, ENSCAFG00000029066, ENSCAFT00000043841, ENSCAFG00000029986, ENSCAFP00000037324, ENSCAFT00000043700, ENSCAFT00000043028, ENSCAFP00000038752, ENSCAFG00000030825, ENSCAFT00000045413, ENSCAFG00000029032, ENSCAFG00000012989, ENSCAFG00000032188, ENSCAFG00000030696, ENSCAFP00000019126, ENSCAFG00000031940, ENSCAFP00000034229, ENSCAFP00000033563

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