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EPS15:HGS:STAM [cytosol]
Stable Identifier
R-CFA-182947
Type
Complex
Species
Canis familiaris
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Signal Transduction (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by EGFR (Canis familiaris)
EGFR downregulation (Canis familiaris)
CBL-mediated ubiquitination of CIN85 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Canis familiaris)
EPS15:HGS:STAM [cytosol] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Canis familiaris)
EPS15:HGS:STAM [cytosol] (Canis familiaris)
EGFR binds EPS15, EPN1, EPS15L1 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
EPS15:HGS:STAM [cytosol] (Canis familiaris)
EPS15:HGS:STAM [cytosol] (Canis familiaris)
EGFR non-clathrin mediated endocytosis (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Canis familiaris)
EPS15:HGS:STAM [cytosol] (Canis familiaris)
EPS15:HGS:STAM [cytosol] (Canis familiaris)
EGFR phosphorylates EPS15 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
EPS15:HGS:STAM [cytosol] (Canis familiaris)
PTPN3 dephosphorylates EPS15 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
EPS15:HGS:STAM [cytosol] (Canis familiaris)
Sprouty sequesters CBL away from active EGFR (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Canis familiaris)
EPS15:HGS:STAM [cytosol] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Canis familiaris)
EPS15:HGS:STAM [cytosol] (Canis familiaris)
Signaling by MET (Canis familiaris)
Negative regulation of MET activity (Canis familiaris)
EPS15 and HGS bind ubiquitinated MET (Canis familiaris)
EPS15:HGS:STAM [cytosol] (Canis familiaris)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM) [plasma membrane] (Canis familiaris)
EPS15:HGS:STAM [cytosol] (Canis familiaris)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
EPS15 [cytosol]
(Canis familiaris)
HGS [cytosol]
(Canis familiaris)
STAM [cytosol]
(Canis familiaris)
Participates
as an input of
EPS15 and HGS bind ubiquitinated MET (Canis familiaris)
EGFR non-clathrin mediated endocytosis (Canis familiaris)
EGFR binds EPS15, EPN1, EPS15L1 (Canis familiaris)
as a component of
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM) [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
Inferred From
EPS15:HGS:STAM [cytosol]
(Homo sapiens)
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