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EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane]
Stable Identifier
R-CFA-182953
Type
Complex
Species
Canis familiaris
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by EGFR (Canis familiaris)
EGFR downregulation (Canis familiaris)
CBL binds and ubiquitinates phosphorylated Sprouty (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Canis familiaris)
CBL-mediated ubiquitination of CIN85 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Canis familiaris)
EGFR non-clathrin mediated endocytosis (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Canis familiaris)
Phosphorylation of CBL (EGFR:CBL) (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Canis familiaris)
Sprouty sequesters CBL away from active EGFR (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Canis familiaris)
Ubiquitination of stimulated EGFR (CBL) (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Canis familiaris)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
EGF-like ligands [extracellular region]
(Canis familiaris)
x 2
phospho-CBL [cytosol]
(Canis familiaris)
x 2
phospho-EGFR [plasma membrane]
(Canis familiaris)
Participates
as an input of
Ubiquitination of stimulated EGFR (CBL) (Canis familiaris)
CBL binds and ubiquitinates phosphorylated Sprouty (Canis familiaris)
EGFR non-clathrin mediated endocytosis (Canis familiaris)
as an output of
Phosphorylation of CBL (EGFR:CBL) (Canis familiaris)
as a component of
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Canis familiaris)
Inferred From
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane]
(Homo sapiens)
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