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phospho-SYK [cytosol]
Stable Identifier
R-CFA-1861712
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
p-6Y-SYK, A0A8I3P3G0
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Canis familiaris)
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Canis familiaris)
BLNK (SLP-65) Signalosome [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
BTK binds BTK inhibitors (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
BTK:BTK inhibitors [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
SYK autophosphorylates at the activated BCR (Canis familiaris)
Antigen:p-BCR:p-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
p-6Y-SYK phosphorylates BLNK (SLP65) (Canis familiaris)
Antigen:p-BCR:p-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
C-type lectin receptors (CLRs) (Canis familiaris)
Dectin-2 family (Canis familiaris)
PLCG2 translocates from cytosol to plasma membrane (Canis familiaris)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2 [plasma membrane] (Canis familiaris)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
SYK autophosphorylates (Canis familiaris)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Canis familiaris)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2 [plasma membrane] (Canis familiaris)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2 [plasma membrane] (Canis familiaris)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
DAP12 interactions (Canis familiaris)
DAP12 signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
Phosphorylation and activation of VAV2/VAV3 by SYK (Canis familiaris)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
SYK/LCK/ZAP-70 [cytosol] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
Phosphorylation of BTK by p-SYK (Canis familiaris)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
SYK/LCK/ZAP-70 [cytosol] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
Phosphorylation of LAT by p-SYK (Canis familiaris)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
SYK/LCK/ZAP-70 [cytosol] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Canis familiaris)
p-SYK,p-BTK [cytosol] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
p-SYK/p-BTK [plasma membrane] (Canis familiaris)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
Phosphorylation of SLP-76 by p-SYK (Canis familiaris)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
SYK/LCK/ZAP-70 [cytosol] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
Phosphorylation of SYK (Canis familiaris)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
p85 regulatory unit of PI3K binds p-6Y-SYK (Canis familiaris)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated Ca+2 mobilization (Canis familiaris)
Phosphorylation of TEC kinases by p-SYK (Canis familiaris)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
FCERI mediated MAPK activation (Canis familiaris)
Phosphorylation of SHC by SYK kinase (Canis familiaris)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
Phosphorylation of SLP-76 by p-SYK (Canis familiaris)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
Phosphorylation of LAT by p-SYK (Canis familiaris)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
Role of LAT2/NTAL/LAB on calcium mobilization (Canis familiaris)
Phosphorylation of NTAL by p-SYK/Lyn (Canis familiaris)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
Regulation of actin dynamics for phagocytic cup formation (Canis familiaris)
Activation of RAC1 by CRKII:DOCK180:ELMO (Canis familiaris)
CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
Activation of RAC1 by VAV (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
Phosphorylation of VAV (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Canis familiaris)
CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
Recruitment of VAV1 to p-6Y-SYK (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
Role of phospholipids in phagocytosis (Canis familiaris)
PI3K binds to p-6Y-SYK (Canis familiaris)
PI3K:p-6Y-SYK [plasma membrane] (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI3K:p-6Y-SYK [plasma membrane] (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
Phosphorylation and activation of PLCG (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
Recruitment of PLCgamma to membrane (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
Release of PLCG from FCGR (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
phospho-SYK [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3P3G0
Gene Names
SYK
Reference Genes
ENSEMBL:ENSCAFG00845018106.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845018106.1 SYK
Reference Transcript
RefSeq:XM_005615953.2 SYK
Other Identifiers
484196
Cfa.18891.1.S1_s_at
CfaAffx.4145.1.S1_at
GO:0000166
GO:0001775
GO:0001784
GO:0001819
GO:0001820
GO:0001945
GO:0002092
GO:0002223
GO:0002281
GO:0002283
GO:0002366
GO:0002376
GO:0002554
GO:0003824
GO:0004672
GO:0004674
GO:0004713
GO:0004715
GO:0005102
GO:0005178
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006468
GO:0006606
GO:0006886
GO:0006913
GO:0006954
GO:0007155
GO:0007159
GO:0007166
GO:0007167
GO:0007229
GO:0010543
GO:0010803
GO:0012501
GO:0016170
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0019370
GO:0019722
GO:0019815
GO:0019901
GO:0019902
GO:0023052
GO:0030154
GO:0030183
GO:0030593
GO:0031334
GO:0031410
GO:0031623
GO:0032009
GO:0032481
GO:0032725
GO:0032733
GO:0032735
GO:0032752
GO:0032753
GO:0032755
GO:0032757
GO:0032760
GO:0032765
GO:0032928
GO:0032930
GO:0032991
GO:0033630
GO:0035325
GO:0035556
GO:0036211
GO:0038063
GO:0038156
GO:0042060
GO:0042101
GO:0042169
GO:0042492
GO:0042742
GO:0043226
GO:0043274
GO:0043303
GO:0043306
GO:0043313
GO:0043366
GO:0043410
GO:0045087
GO:0045579
GO:0045588
GO:0045780
GO:0046638
GO:0046641
GO:0048514
GO:0048856
GO:0048870
GO:0050731
GO:0050764
GO:0050850
GO:0050853
GO:0051649
GO:0051712
GO:0065003
GO:0070372
GO:0071226
GO:0071396
GO:0071404
GO:0071639
GO:0090237
GO:0090330
GO:0097110
GO:0098542
GO:0120162
GO:0140096
GO:1904263
GO:1990858
Participates
as a component of
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Canis familiaris)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Canis familiaris)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Canis familiaris)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK [plasma membrane] (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
as a member of
p-SYK,p-BTK [cytosol] (Canis familiaris)
SYK/LCK/ZAP-70 [cytosol] (Canis familiaris)
Other forms of this molecule
phospho-SYK [cytosol]
phospho-SYK [plasma membrane]
phospho-SYK [cytosol]
SYK [cytosol]
Inferred From
p-6Y-SYK [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 348 (in Homo sapiens)
Coordinate
348
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 352 (in Homo sapiens)
Coordinate
352
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 525 (in Homo sapiens)
Coordinate
525
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 526 (in Homo sapiens)
Coordinate
526
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 131 (in Homo sapiens)
Coordinate
131
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 323 (in Homo sapiens)
Coordinate
323
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
XP_005616010.1
OpenTargets
ENSG00000165025
Ensembl
ENSCAFG00845018106
,
ENSCAFT00845032058
,
ENSCAFP00845025066
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