Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
SKP1 [nucleoplasm]
Stable Identifier
R-CFA-187538
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
nucleoplasm
Synonyms
A0A8I3P1G9
Locations in the PathwayBrowser
Expand all
Cell Cycle (Canis familiaris)
Cell Cycle Checkpoints (Canis familiaris)
G1/S DNA Damage Checkpoints (Canis familiaris)
p53-Independent G1/S DNA Damage Checkpoint (Canis familiaris)
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Canis familiaris)
Ubiquitination of phosphorylated CDC25A (Canis familiaris)
SCF-BTrCP1,2 [nucleoplasm] (Canis familiaris)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Canis familiaris)
SKP1 [nucleoplasm] (Canis familiaris)
SCF-FBXW11 [nucleoplasm] (Canis familiaris)
SKP1 [nucleoplasm] (Canis familiaris)
Cell Cycle, Mitotic (Canis familiaris)
Mitotic G1 phase and G1/S transition (Canis familiaris)
G1 Phase (Canis familiaris)
Cyclin D associated events in G1 (Canis familiaris)
Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Canis familiaris)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Canis familiaris)
CUL1:SKP1:SKP2 [nucleoplasm] (Canis familiaris)
SKP1 [nucleoplasm] (Canis familiaris)
p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm] (Canis familiaris)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Canis familiaris)
CUL1:SKP1:SKP2 [nucleoplasm] (Canis familiaris)
SKP1 [nucleoplasm] (Canis familiaris)
Ubiquitination of p130 (RBL2) by SCF (Skp2) (Canis familiaris)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Canis familiaris)
CUL1:SKP1:SKP2 [nucleoplasm] (Canis familiaris)
SKP1 [nucleoplasm] (Canis familiaris)
p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm] (Canis familiaris)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Canis familiaris)
CUL1:SKP1:SKP2 [nucleoplasm] (Canis familiaris)
SKP1 [nucleoplasm] (Canis familiaris)
G1/S Transition (Canis familiaris)
Cyclin E associated events during G1/S transition (Canis familiaris)
SCF(Skp2)-mediated degradation of p27/p21 (Canis familiaris)
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Canis familiaris)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Canis familiaris)
CUL1:SKP1:SKP2 [nucleoplasm] (Canis familiaris)
SKP1 [nucleoplasm] (Canis familiaris)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Canis familiaris)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Canis familiaris)
CUL1:SKP1:SKP2 [nucleoplasm] (Canis familiaris)
SKP1 [nucleoplasm] (Canis familiaris)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Canis familiaris)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Canis familiaris)
CUL1:SKP1:SKP2 [nucleoplasm] (Canis familiaris)
SKP1 [nucleoplasm] (Canis familiaris)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Canis familiaris)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Canis familiaris)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Canis familiaris)
CUL1:SKP1:SKP2 [nucleoplasm] (Canis familiaris)
SKP1 [nucleoplasm] (Canis familiaris)
Ubiquitination of phospho-p27/p21 (Canis familiaris)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Canis familiaris)
CUL1:SKP1:SKP2 [nucleoplasm] (Canis familiaris)
SKP1 [nucleoplasm] (Canis familiaris)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Canis familiaris)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Canis familiaris)
CUL1:SKP1:SKP2 [nucleoplasm] (Canis familiaris)
SKP1 [nucleoplasm] (Canis familiaris)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Canis familiaris)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Canis familiaris)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Canis familiaris)
CUL1:SKP1:SKP2 [nucleoplasm] (Canis familiaris)
SKP1 [nucleoplasm] (Canis familiaris)
S Phase (Canis familiaris)
Cyclin A:Cdk2-associated events at S phase entry (Canis familiaris)
SCF(Skp2)-mediated degradation of p27/p21 (Canis familiaris)
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Canis familiaris)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Canis familiaris)
CUL1:SKP1:SKP2 [nucleoplasm] (Canis familiaris)
SKP1 [nucleoplasm] (Canis familiaris)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Canis familiaris)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Canis familiaris)
CUL1:SKP1:SKP2 [nucleoplasm] (Canis familiaris)
SKP1 [nucleoplasm] (Canis familiaris)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Canis familiaris)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Canis familiaris)
CUL1:SKP1:SKP2 [nucleoplasm] (Canis familiaris)
SKP1 [nucleoplasm] (Canis familiaris)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Canis familiaris)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Canis familiaris)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Canis familiaris)
CUL1:SKP1:SKP2 [nucleoplasm] (Canis familiaris)
SKP1 [nucleoplasm] (Canis familiaris)
Ubiquitination of phospho-p27/p21 (Canis familiaris)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Canis familiaris)
CUL1:SKP1:SKP2 [nucleoplasm] (Canis familiaris)
SKP1 [nucleoplasm] (Canis familiaris)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Canis familiaris)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Canis familiaris)
CUL1:SKP1:SKP2 [nucleoplasm] (Canis familiaris)
SKP1 [nucleoplasm] (Canis familiaris)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Canis familiaris)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Canis familiaris)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Canis familiaris)
CUL1:SKP1:SKP2 [nucleoplasm] (Canis familiaris)
SKP1 [nucleoplasm] (Canis familiaris)
Synthesis of DNA (Canis familiaris)
Switching of origins to a post-replicative state (Canis familiaris)
Orc1 removal from chromatin (Canis familiaris)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Canis familiaris)
SCF (SKP2) complex [nucleoplasm] (Canis familiaris)
SKP1 [nucleoplasm] (Canis familiaris)
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to chemical stress (Canis familiaris)
KEAP1-NFE2L2 pathway (Canis familiaris)
Nuclear events mediated by NFE2L2 (Canis familiaris)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Canis familiaris)
BTRC binds p-S344, 347 NFE2L2 (Canis familiaris)
BTRC:SKP1:CUL1:RBX1:p-S344, S347 NFE2L2 [nucleoplasm] (Canis familiaris)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Canis familiaris)
SKP1 [nucleoplasm] (Canis familiaris)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Canis familiaris)
SKP1 [nucleoplasm] (Canis familiaris)
NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Canis familiaris)
BTRC:SKP1:CUL1:RBX1:p-S344, S347 NFE2L2 [nucleoplasm] (Canis familiaris)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Canis familiaris)
SKP1 [nucleoplasm] (Canis familiaris)
BTRC:SKP1:CUL1:RBX1:ub,p-S335, S338 NFE2L2 [nucleoplasm] (Canis familiaris)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Canis familiaris)
SKP1 [nucleoplasm] (Canis familiaris)
Ub,pS335,S338,T NFE2L2 is degraded (Canis familiaris)
BTRC:SKP1:CUL1:RBX1:ub,p-S335, S338 NFE2L2 [nucleoplasm] (Canis familiaris)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Canis familiaris)
SKP1 [nucleoplasm] (Canis familiaris)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Canis familiaris)
SKP1 [nucleoplasm] (Canis familiaris)
DNA Replication (Canis familiaris)
Synthesis of DNA (Canis familiaris)
Switching of origins to a post-replicative state (Canis familiaris)
Orc1 removal from chromatin (Canis familiaris)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Canis familiaris)
SCF (SKP2) complex [nucleoplasm] (Canis familiaris)
SKP1 [nucleoplasm] (Canis familiaris)
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional regulation by RUNX2 (Canis familiaris)
Regulation of RUNX2 expression and activity (Canis familiaris)
SCF(SKP2) complex binds RUNX2 (Canis familiaris)
RUNX2:SCF(SKP2) [nucleoplasm] (Canis familiaris)
SCF (SKP2) complex [nucleoplasm] (Canis familiaris)
SKP1 [nucleoplasm] (Canis familiaris)
SCF (SKP2) complex [nucleoplasm] (Canis familiaris)
SKP1 [nucleoplasm] (Canis familiaris)
SCF(SKP2) polyubiquitinates RUNX2 (Canis familiaris)
RUNX2:SCF(SKP2) [nucleoplasm] (Canis familiaris)
SCF (SKP2) complex [nucleoplasm] (Canis familiaris)
SKP1 [nucleoplasm] (Canis familiaris)
SCF (SKP2) complex [nucleoplasm] (Canis familiaris)
SKP1 [nucleoplasm] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3P1G9
Reference Genes
ENSEMBL:ENSCAFG00845014012.1
UCSC:A0A8I3P1G9
Other Identifiers
Cfa.11240.1.S1_s_at
CfaAffx.7777.1.S1_s_at
GO:0005634
GO:0005737
GO:0006511
GO:0016567
GO:0019005
GO:0030163
GO:0031146
GO:0097602
Participates
as a component of
SCF (SKP2) complex [nucleoplasm] (Canis familiaris)
SCF-FBXW11 [nucleoplasm] (Canis familiaris)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Canis familiaris)
CUL1:SKP1:SKP2 [nucleoplasm] (Canis familiaris)
Other forms of this molecule
SKP1 [cytosol]
Inferred From
SKP1 [nucleoplasm]
(Homo sapiens)
Cross References
ENSEMBL
ENSCAFG00845014012
,
ENSCAFP00845019709
,
ENSCAFT00845025049
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text