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VAV2 [cytosol]
Stable Identifier
R-CFA-195012
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
VAV2, A0A8I3NEZ8
Locations in the PathwayBrowser
Expand all
Developmental Biology (Canis familiaris)
Nervous system development (Canis familiaris)
Axon guidance (Canis familiaris)
EPH-Ephrin signaling (Canis familiaris)
EPH-ephrin mediated repulsion of cells (Canis familiaris)
SFKs phosphorylate VAV2,3 (Canis familiaris)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Canis familiaris)
VAV2,VAV3 [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
p-EPHs bind VAV2,3 (Canis familiaris)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Canis familiaris)
VAV2,VAV3 [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
VAV2,VAV3 [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
Hemostasis (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
GPVI-mediated activation cascade (Canis familiaris)
VAV1 is a GEF for Rho/Rac family GTPases (Canis familiaris)
PIP3:VAV1,2,3 [plasma membrane] (Canis familiaris)
VAV1,2,3 [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
VAV family:PIP2 [plasma membrane] (Canis familiaris)
VAV family [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
p-SLP-76 binds VAV (Canis familiaris)
VAV1,2,3 [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
p-SLP-76:VAV [cytosol] (Canis familiaris)
VAV1,2,3 [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Innate Immune System (Canis familiaris)
DAP12 interactions (Canis familiaris)
DAP12 signaling (Canis familiaris)
Phosphorylation and activation of VAV2/VAV3 by SYK (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Canis familiaris)
VAV2,VAV3 [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
Phosphorylation of BTK by p-SYK (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Canis familiaris)
VAV2,VAV3 [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Canis familiaris)
VAV2,VAV3 [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Canis familiaris)
VAV2,VAV3 [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Canis familiaris)
VAV2,VAV3 [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
p-SYK/p-BTK [plasma membrane] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Canis familiaris)
VAV2,VAV3 [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
Recruitment of VAV and BTK to p-SLP-76 (Canis familiaris)
VAV2,VAV3 [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Canis familiaris)
VAV2,VAV3 [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
Release of p-PLCG1 (Canis familiaris)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Canis familiaris)
VAV2,VAV3 [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Canis familiaris)
VAV2,VAV3 [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated Ca+2 mobilization (Canis familiaris)
Autophosphorylation of BTK/ITK (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Canis familiaris)
VAV1,2,3 [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Canis familiaris)
VAV1,2,3 [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
Hydrolysis of PIP2 by PLCG (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Canis familiaris)
VAV1,2,3 [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
Phosphorylation of TEC kinases by p-SYK (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Canis familiaris)
VAV1,2,3 [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Canis familiaris)
VAV1,2,3 [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
FCERI mediated MAPK activation (Canis familiaris)
Phosphorylation and activation of VAV (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Canis familiaris)
VAV1,2,3 [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
Recruitment of VAV to p-SLP-76 (Canis familiaris)
VAV1,2,3 [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Canis familiaris)
VAV1,2,3 [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
Regulation of actin dynamics for phagocytic cup formation (Canis familiaris)
Phosphorylation of VAV (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Canis familiaris)
VAV1,2,3 [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
Recruitment of VAV1 to p-6Y-SYK (Canis familiaris)
VAV1,2,3 [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Canis familiaris)
VAV1,2,3 [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Death Receptor Signaling (Canis familiaris)
p75 NTR receptor-mediated signalling (Canis familiaris)
Cell death signalling via NRAGE, NRIF and NADE (Canis familiaris)
NRAGE signals death through JNK (Canis familiaris)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Canis familiaris)
GEFs [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (12/13) signalling events (Canis familiaris)
GEFs activate RhoA,B,C (Canis familiaris)
GEFs [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by VEGF (Canis familiaris)
VEGFA-VEGFR2 Pathway (Canis familiaris)
Src kinases phosphorylate VAV (Canis familiaris)
PIP3:VAV1,2,3 [plasma membrane] (Canis familiaris)
VAV1,2,3 [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
VAV exchanges GTP for GDP on RAC1, activating it (Canis familiaris)
VAV family [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase cycle (Canis familiaris)
CDC42 GTPase cycle (Canis familiaris)
CDC42 GEFs activate CDC42 (Canis familiaris)
CDC42 GEFs [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
RAC1 GTPase cycle (Canis familiaris)
RAC1 GEFs activate RAC1 (Canis familiaris)
RAC1 GEFs [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
RAC2 GTPase cycle (Canis familiaris)
RAC2 GEFs activate RAC2 (Canis familiaris)
RAC2 GEFs [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
RAC3 GTPase cycle (Canis familiaris)
RAC3 GEFs activate RAC3 (Canis familiaris)
RAC3 GEFs [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
RHOA GTPase cycle (Canis familiaris)
RHOA GEFs activate RHOA (Canis familiaris)
RHOA GEFs [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
RHOB GTPase cycle (Canis familiaris)
RHOB GEFs activate RHOB (Canis familiaris)
RHOB GEFs [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
RHOC GTPase cycle (Canis familiaris)
RHOC GEFs activate RHOC (Canis familiaris)
RHOC GEFs [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
RHOG GTPase cycle (Canis familiaris)
RHOG GEFs activate RHOG (Canis familiaris)
RHOG GEFs [cytosol] (Canis familiaris)
VAV2 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3NEZ8
Gene Names
VAV2
Reference Genes
ENSEMBL:ENSCAFG00845011337.1
UCSC:A0A8I3NEZ8 VAV2
Other Identifiers
CfaAffx.30313.1.S1_at
CfaAffx.30313.1.S1_s_at
GO:0001784
GO:0005085
GO:0005154
GO:0005737
GO:0005886
GO:0007165
GO:0007264
GO:0008361
GO:0016477
GO:0030031
GO:0030032
GO:0035556
GO:0046872
GO:0048870
GO:0051897
GO:0098772
Participates
as a member of
RHOA GEFs [cytosol] (Canis familiaris)
RHOC GEFs [cytosol] (Canis familiaris)
RAC2 GEFs [cytosol] (Canis familiaris)
RAC1 GEFs [cytosol] (Canis familiaris)
RHOB GEFs [cytosol] (Canis familiaris)
RAC3 GEFs [cytosol] (Canis familiaris)
VAV2,VAV3 [cytosol] (Canis familiaris)
GEFs [cytosol] (Canis familiaris)
VAV family [cytosol] (Canis familiaris)
VAV1,2,3 [cytosol] (Canis familiaris)
as a candidate of
CDC42 GEFs [cytosol] (Canis familiaris)
RHOG GEFs [cytosol] (Canis familiaris)
Other forms of this molecule
phospho-VAV2 [cytosol]
Inferred From
VAV2 [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSCAFT00845020123
,
ENSCAFP00845015773
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