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BTK [cytosol]
Stable Identifier
R-CFA-197948
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
A0A8I3P7Z3
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Canis familiaris)
BTK binds BTK inhibitors (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Canis familiaris)
BTK:PIP3 [plasma membrane] (Canis familiaris)
BTK [cytosol] (Canis familiaris)
BTK:BTK inhibitors [plasma membrane] (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Canis familiaris)
BTK:PIP3 [plasma membrane] (Canis familiaris)
BTK [cytosol] (Canis familiaris)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Canis familiaris)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Canis familiaris)
BTK:PIP3 [plasma membrane] (Canis familiaris)
BTK [cytosol] (Canis familiaris)
BTK [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
DAP12 interactions (Canis familiaris)
DAP12 signaling (Canis familiaris)
Activation of RAC1 by VAV2/3 (Canis familiaris)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Canis familiaris)
BTK [cytosol] (Canis familiaris)
Phosphorylation and activation of VAV2/VAV3 by SYK (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Canis familiaris)
BTK [cytosol] (Canis familiaris)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Canis familiaris)
BTK [cytosol] (Canis familiaris)
Phosphorylation of BTK by p-SYK (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Canis familiaris)
BTK [cytosol] (Canis familiaris)
Recruitment of VAV and BTK to p-SLP-76 (Canis familiaris)
BTK [cytosol] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Canis familiaris)
BTK [cytosol] (Canis familiaris)
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated Ca+2 mobilization (Canis familiaris)
Phosphorylation of TEC kinases by p-SYK (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Canis familiaris)
TEC,BTK,ITK,(TXK) [cytosol] (Canis familiaris)
BTK [cytosol] (Canis familiaris)
Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
Regulation of actin dynamics for phagocytic cup formation (Canis familiaris)
Src phosphorylate WASP,N-WASP (Canis familiaris)
Src-kinases [cytosol] (Canis familiaris)
BTK [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (12/13) signalling events (Canis familiaris)
BTK in G alpha (12)-BTK complex is activated (Canis familiaris)
G alpha (12):BTK [plasma membrane] (Canis familiaris)
BTK [cytosol] (Canis familiaris)
G alpha (12) binds BTK (Canis familiaris)
BTK [cytosol] (Canis familiaris)
G alpha (12):BTK [plasma membrane] (Canis familiaris)
BTK [cytosol] (Canis familiaris)
G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Canis familiaris)
BTK [cytosol] (Canis familiaris)
G alpha (12):BTK [plasma membrane] (Canis familiaris)
BTK [cytosol] (Canis familiaris)
G alpha (q) signalling events (Canis familiaris)
Active Gq binds BTK (Canis familiaris)
Active Gq:BTK [plasma membrane] (Canis familiaris)
BTK [cytosol] (Canis familiaris)
BTK [cytosol] (Canis familiaris)
BTK in active Gq-BTK complex is activated (Canis familiaris)
Active Gq:BTK [plasma membrane] (Canis familiaris)
BTK [cytosol] (Canis familiaris)
Gq-BTK complex dissociates to Active BTK and Gq (Canis familiaris)
Active Gq:BTK [plasma membrane] (Canis familiaris)
BTK [cytosol] (Canis familiaris)
BTK [cytosol] (Canis familiaris)
G-protein beta:gamma signalling (Canis familiaris)
G beta:gamma signalling through BTK (Canis familiaris)
BTK in PIP3:BTK:G beta-gamma complex is activated (Canis familiaris)
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Canis familiaris)
BTK [cytosol] (Canis familiaris)
G beta-gamma complex and PIP3 recruit BTK to membrane (Canis familiaris)
BTK [cytosol] (Canis familiaris)
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Canis familiaris)
BTK [cytosol] (Canis familiaris)
PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Canis familiaris)
BTK [cytosol] (Canis familiaris)
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Canis familiaris)
BTK [cytosol] (Canis familiaris)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase Effectors (Canis familiaris)
RHO GTPases Activate WASPs and WAVEs (Canis familiaris)
Src phosphorylate WASP,N-WASP (Canis familiaris)
Src-kinases [cytosol] (Canis familiaris)
BTK [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3P7Z3
Reference Genes
ENSEMBL:ENSCAFG00845018798.1
UCSC:A0A8I3P7Z3
Other Identifiers
Cfa.16454.1.S1_at
CfaAffx.27056.1.S1_s_at
GO:0001818
GO:0002250
GO:0002344
GO:0002376
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0005524
GO:0005547
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0008289
GO:0016004
GO:0016740
GO:0030889
GO:0031410
GO:0035556
GO:0042802
GO:0043226
GO:0043274
GO:0045121
GO:0046872
GO:0048469
GO:0050852
GO:0050853
GO:0098761
GO:0098772
GO:0140096
GO:1900227
Participates
as an output of
Gq-BTK complex dissociates to Active BTK and Gq (Canis familiaris)
G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Canis familiaris)
PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Canis familiaris)
as an input of
Active Gq binds BTK (Canis familiaris)
G alpha (12) binds BTK (Canis familiaris)
G beta-gamma complex and PIP3 recruit BTK to membrane (Canis familiaris)
Recruitment of VAV and BTK to p-SLP-76 (Canis familiaris)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Canis familiaris)
as a component of
Active Gq:BTK [plasma membrane] (Canis familiaris)
G alpha (12):BTK [plasma membrane] (Canis familiaris)
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Canis familiaris)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Canis familiaris)
BTK:PIP3 [plasma membrane] (Canis familiaris)
as a member of
TEC,BTK,ITK,(TXK) [cytosol] (Canis familiaris)
as a candidate of
Src-kinases [cytosol] (Canis familiaris)
Other forms of this molecule
phospho-p-Y223,Y551-BTK [cytosol]
phospho-p-Y551-BTK [cytosol]
phospho-p-Y223,Y551-BTK [plasma membrane]
Inferred From
Active BTK [cytosol]
(Homo sapiens)
BTK [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSCAFP00845026318
,
ENSCAFT00845033615
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