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PTEN [cytosol]
Stable Identifier
R-CFA-199420
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
PTEN, P60483
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
TCR signaling (Canis familiaris)
Downstream TCR signaling (Canis familiaris)
PTEN dephosphorylates PIP3 (Canis familiaris)
PTEN [cytosol] (Canis familiaris)
Metabolism (Canis familiaris)
Inositol phosphate metabolism (Canis familiaris)
Synthesis of IP3 and IP4 in the cytosol (Canis familiaris)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Canis familiaris)
PTEN:Mg2+ [cytosol] (Canis familiaris)
PTEN [cytosol] (Canis familiaris)
Metabolism of lipids (Canis familiaris)
Phospholipid metabolism (Canis familiaris)
PI Metabolism (Canis familiaris)
Synthesis of PIPs at the plasma membrane (Canis familiaris)
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Canis familiaris)
PTEN [cytosol] (Canis familiaris)
PTEN dephosphorylates PIP3 (Canis familiaris)
PTEN [cytosol] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Deubiquitination (Canis familiaris)
Ovarian tumor domain proteases (Canis familiaris)
OTUD3 deubiquitinates PTEN (Canis familiaris)
PTEN [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PTEN dephosphorylates PIP3 (Canis familiaris)
PTEN [cytosol] (Canis familiaris)
PTEN Regulation (Canis familiaris)
Regulation of PTEN localization (Canis familiaris)
Deubiquitinated PTEN translocates to the cytosol (Canis familiaris)
PTEN [cytosol] (Canis familiaris)
PTEN undergoes monoubiquitination (Canis familiaris)
PTEN [cytosol] (Canis familiaris)
Regulation of PTEN stability and activity (Canis familiaris)
Casein kinase II phosphorylates PTEN (Canis familiaris)
PTEN [cytosol] (Canis familiaris)
FRK phosphorylates PTEN (Canis familiaris)
PTEN:p-Y387-FRK [cytosol] (Canis familiaris)
PTEN [cytosol] (Canis familiaris)
MKRN1 polyubiquitinates PTEN (Canis familiaris)
PTEN [cytosol] (Canis familiaris)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Canis familiaris)
PTEN [cytosol] (Canis familiaris)
PREX2 binds PTEN and inhibits it (Canis familiaris)
PREX2:PTEN,p-3S,2T-PTEN [cytosol] (Canis familiaris)
PTEN, p-3S,2T-PTEN [cytosol] (Canis familiaris)
PTEN [cytosol] (Canis familiaris)
PTEN, p-3S,2T-PTEN [cytosol] (Canis familiaris)
PTEN [cytosol] (Canis familiaris)
PTEN binds FRK (Canis familiaris)
PTEN [cytosol] (Canis familiaris)
PTEN:p-Y387-FRK [cytosol] (Canis familiaris)
PTEN [cytosol] (Canis familiaris)
TNKS and TNKS2 PARylate PTEN (Canis familiaris)
PTEN [cytosol] (Canis familiaris)
TRIM27 binds PTEN (Canis familiaris)
PTEN [cytosol] (Canis familiaris)
PTEN:TRIM27 [cytosol] (Canis familiaris)
PTEN [cytosol] (Canis familiaris)
TRIM27 polyubiquitinates PTEN (Canis familiaris)
PTEN:TRIM27 [cytosol] (Canis familiaris)
PTEN [cytosol] (Canis familiaris)
USP13 and OTUD3 deubiquitinate PTEN (Canis familiaris)
PTEN [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:P60483
Gene Names
PTEN
Reference Genes
BioGPS Gene:403832 PTEN
ENSEMBL:ENSCAFG00030021263
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00030021263.1 PTEN
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00040023806.1 PTEN
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845029443.1 PTEN
KEGG Gene (Canis lupus familiaris):403832 PTEN
Monarch:403832 PTEN
NCBI Gene:403832 PTEN
Reference Transcript
RefSeq:NM_001003192.1 PTEN
Other Identifiers
403832
Cfa.10951.1.A1_at
Cfa.3695.1.S1_s_at
GO:0000278
GO:0001933
GO:0003824
GO:0004438
GO:0004721
GO:0004722
GO:0004725
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006629
GO:0007010
GO:0007056
GO:0007059
GO:0007155
GO:0008285
GO:0009898
GO:0010719
GO:0010997
GO:0016311
GO:0016314
GO:0016324
GO:0016787
GO:0016791
GO:0019899
GO:0022414
GO:0023052
GO:0030154
GO:0030163
GO:0030165
GO:0030336
GO:0031647
GO:0033137
GO:0034330
GO:0036211
GO:0042060
GO:0042802
GO:0042995
GO:0043226
GO:0046856
GO:0048856
GO:0048870
GO:0050821
GO:0051548
GO:0051717
GO:0051800
GO:0051895
GO:0051898
GO:0052866
GO:0060070
GO:0071257
GO:0140013
GO:0140096
GO:1902807
GO:1903690
GO:1904706
GO:1990381
GO:2000060
GO:2000134
Participates
as an output of
OTUD3 deubiquitinates PTEN (Canis familiaris)
USP13 and OTUD3 deubiquitinate PTEN (Canis familiaris)
Deubiquitinated PTEN translocates to the cytosol (Canis familiaris)
as a member of
PTEN, p-3S,2T-PTEN [cytosol] (Canis familiaris)
as an input of
MKRN1 polyubiquitinates PTEN (Canis familiaris)
TNKS and TNKS2 PARylate PTEN (Canis familiaris)
PTEN binds FRK (Canis familiaris)
Casein kinase II phosphorylates PTEN (Canis familiaris)
TRIM27 binds PTEN (Canis familiaris)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Canis familiaris)
PTEN undergoes monoubiquitination (Canis familiaris)
as a component of
PTEN:p-Y387-FRK [cytosol] (Canis familiaris)
PTEN:TRIM27 [cytosol] (Canis familiaris)
PTEN:Mg2+ [cytosol] (Canis familiaris)
Other forms of this molecule
PTEN [cytosol]
PTEN [nucleoplasm]
phospho-PTEN [cytosol]
PTEN [nucleoplasm]
PTEN [nucleoplasm]
PTEN [cytosol]
PTEN [cytosol]
PTEN [cytosol]
PTEN [cytosol]
phospho-PTEN [cytosol]
phospho-PTEN [cytosol]
phospho-PTEN [cytosol]
Inferred From
PTEN [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001003192.1
OpenTargets
ENSG00000171862
IntEnz
3.1.3.16
,
3.1.3.48
,
3.1.3.67
Ensembl
ENSCAFG00845029443
,
ENSCAFP00845040898
,
ENSCAFT00845052143
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