Reactome | RPS6KA3 [nucleoplasm]

RPS6KA3 [nucleoplasm]

Stable Identifier

R-CFA-199869

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

A0A8I3PZN8

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Canis familiaris)

- Cellular responses to stress (Canis familiaris)
  - Cellular Senescence (Canis familiaris)
    - Senescence-Associated Secretory Phenotype (SASP) (Canis familiaris)
      - ERK1/2/5 activate RSK1/2/3 (Canis familiaris)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Canis familiaris)
        
        RPS6KA3 [nucleoplasm] (Canis familiaris)

Immune System (Canis familiaris)

- Cytokine Signaling in Immune system (Canis familiaris)
  - Signaling by Interleukins (Canis familiaris)
    - Interleukin-17 signaling (Canis familiaris)
      - MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        ERK/MAPK targets (Canis familiaris)
        
        ERK1/2/5 activate RSK1/2/3 (Canis familiaris)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Canis familiaris)
        
        RPS6KA3 [nucleoplasm] (Canis familiaris)
- Innate Immune System (Canis familiaris)
  - Toll-like Receptor Cascades (Canis familiaris)
    - Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
      - MyD88 cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        ERK/MAPK targets (Canis familiaris)
        
        ERK1/2/5 activate RSK1/2/3 (Canis familiaris)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Canis familiaris)
        
        RPS6KA3 [nucleoplasm] (Canis familiaris)
    - Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
      - Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        ERK/MAPK targets (Canis familiaris)
        
        ERK1/2/5 activate RSK1/2/3 (Canis familiaris)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Canis familiaris)
        
        RPS6KA3 [nucleoplasm] (Canis familiaris)
      - Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        ERK/MAPK targets (Canis familiaris)
        
        ERK1/2/5 activate RSK1/2/3 (Canis familiaris)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Canis familiaris)
        
        RPS6KA3 [nucleoplasm] (Canis familiaris)
    - Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
      - MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        ERK/MAPK targets (Canis familiaris)
        
        ERK1/2/5 activate RSK1/2/3 (Canis familiaris)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Canis familiaris)
        
        RPS6KA3 [nucleoplasm] (Canis familiaris)
    - Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
      - MyD88-independent TLR4 cascade (Canis familiaris)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        ERK/MAPK targets (Canis familiaris)
        
        ERK1/2/5 activate RSK1/2/3 (Canis familiaris)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Canis familiaris)
        
        RPS6KA3 [nucleoplasm] (Canis familiaris)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        ERK/MAPK targets (Canis familiaris)
        
        ERK1/2/5 activate RSK1/2/3 (Canis familiaris)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Canis familiaris)
        
        RPS6KA3 [nucleoplasm] (Canis familiaris)
    - Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
      - MyD88 cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        ERK/MAPK targets (Canis familiaris)
        
        ERK1/2/5 activate RSK1/2/3 (Canis familiaris)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Canis familiaris)
        
        RPS6KA3 [nucleoplasm] (Canis familiaris)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
      - MyD88 dependent cascade initiated on endosome (Canis familiaris)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        ERK/MAPK targets (Canis familiaris)
        
        ERK1/2/5 activate RSK1/2/3 (Canis familiaris)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Canis familiaris)
        
        RPS6KA3 [nucleoplasm] (Canis familiaris)
    - Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
      - MyD88 dependent cascade initiated on endosome (Canis familiaris)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        ERK/MAPK targets (Canis familiaris)
        
        ERK1/2/5 activate RSK1/2/3 (Canis familiaris)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Canis familiaris)
        
        RPS6KA3 [nucleoplasm] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Signaling by GPCR (Canis familiaris)
  - GPCR downstream signalling (Canis familiaris)
    - G alpha (q) signalling events (Canis familiaris)
      - Gastrin-CREB signalling pathway via PKC and MAPK (Canis familiaris)
        
        ERK1/2/5 activate RSK1/2/3 (Canis familiaris)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Canis familiaris)
        
        RPS6KA3 [nucleoplasm] (Canis familiaris)
- Signaling by Receptor Tyrosine Kinases (Canis familiaris)
  - Signaling by NTRKs (Canis familiaris)
    - Signaling by NTRK1 (TRKA) (Canis familiaris)
      - Nuclear Events (kinase and transcription factor activation) (Canis familiaris)
        
        ERK/MAPK targets (Canis familiaris)
        
        ERK1/2/5 activate RSK1/2/3 (Canis familiaris)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Canis familiaris)
        
        RPS6KA3 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3PZN8

Reference Genes

ENSEMBL:ENSCAFG00845029219.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845029219.1

Other Identifiers

119868388

Cfa.19022.1.S1_s_at

CfaAffx.20420.1.S1_at

GO:0000166

GO:0000287

GO:0002224

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0005524

GO:0005634

GO:0005654

GO:0005730

GO:0005829

GO:0006351

GO:0006355

GO:0006468

GO:0012501

GO:0016301

GO:0016310

GO:0016740

GO:0019901

GO:0023052

GO:0032496

GO:0035556

GO:0036211

GO:0043027

GO:0043226

GO:0045944

GO:0098542

GO:0098772

GO:0140096

Participates

as a member of

Ribosomal protein S6 kinase [nucleoplasm] (Canis familiaris)

Other forms of this molecule

phospho-p-4S,T231,T365-RPS6KA3 [nucleoplasm]

phospho-p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol]

phospho-p-S227,T365,S369,S386,T577,T737-RPS6KA3 [nucleoplasm]

Inferred From

RPS6KA3 [nucleoplasm] (Homo sapiens)

Cross References

Ensembl

ENSCAFT00845051805, ENSCAFP00845040650, ENSCAFG00845029219

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