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NCKAP1 [cytosol]
Stable Identifier
R-CFA-200979
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
NCKAP1, A0A8I3NZ88
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Innate Immune System (Canis familiaris)
Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
Regulation of actin dynamics for phagocytic cup formation (Canis familiaris)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Canis familiaris)
Mother filament:branching complex [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
p-Y,S,T-WRC [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
p-Y-WRC [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
p-Y,S,T-WRC [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
p-Y-WRC [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
ABL phosphorylates WAVEs (Canis familiaris)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
WAVE Regulatory Complex [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
p-Y-WRC [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
Detachment of WASP/WAVE (Canis familiaris)
Mother filament:branching complex [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
p-Y,S,T-WRC [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
p-Y-WRC [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
p-Y,S,T-WRC [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
p-Y-WRC [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Canis familiaris)
WAVE Regulatory Complex [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
WAVE Regulatory Complex [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
p-ERK phosphorylates WAVEs and ABI (Canis familiaris)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
p-Y,S,T-WRC [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
p-Y-WRC [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by VEGF (Canis familiaris)
VEGFA-VEGFR2 Pathway (Canis familiaris)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Canis familiaris)
WAVE Regulatory Complex [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
WAVE Regulatory Complex [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase Effectors (Canis familiaris)
RHO GTPases Activate WASPs and WAVEs (Canis familiaris)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Canis familiaris)
Mother filament:branching complex [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
p-Y,S,T-WRC [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
p-Y-WRC [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
p-Y,S,T-WRC [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
p-Y-WRC [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
ABL phosphorylates WAVEs (Canis familiaris)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
WAVE Regulatory Complex [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
p-Y-WRC [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
Detachment of WASP/WAVE (Canis familiaris)
Mother filament:branching complex [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
p-Y,S,T-WRC [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
p-Y-WRC [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
p-Y,S,T-WRC [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
p-Y-WRC [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Canis familiaris)
WAVE Regulatory Complex [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
WAVE Regulatory Complex [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
p-ERK phosphorylates WAVEs and ABI (Canis familiaris)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
p-Y,S,T-WRC [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
p-Y-WRC [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
RHO GTPase cycle (Canis familiaris)
RAC1 GTPase cycle (Canis familiaris)
RAC1 binds effectors at the plasma membrane (Canis familiaris)
RAC1 effectors [cytosol] (Canis familiaris)
WAVE Regulatory Complex [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
RAC1:GTP:RAC1 effectors [plasma membrane] (Canis familiaris)
RAC1 effectors [cytosol] (Canis familiaris)
WAVE Regulatory Complex [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
RAC2 GTPase cycle (Canis familiaris)
RAC2 binds effectors at the plasma membrane (Canis familiaris)
RAC2 plasma membrane effectors [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
WAVE2 Regulatory Complex [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Canis familiaris)
RAC2 plasma membrane effectors [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
WAVE2 Regulatory Complex [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
RAC3 GTPase cycle (Canis familiaris)
RAC3 binds effectors at the plasma membrane (Canis familiaris)
RAC3 effectors [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
WAVE1 Regulatory Complex [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
WAVE2 Regulatory Complex [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
RAC3:GTP:RAC3 effectors [plasma membrane] (Canis familiaris)
RAC3 effectors [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
WAVE1 Regulatory Complex [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
WAVE2 Regulatory Complex [cytosol] (Canis familiaris)
NCKAP1 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3NZ88
Gene Names
NCKAP1
Reference Genes
ENSEMBL:ENSCAFG00845016102.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845016102.1 NCKAP1
Other Identifiers
478828
Cfa.19712.1.S1_s_at
Cfa.560.1.S1_at
CfaAffx.22232.1.S1_s_at
GO:0007010
GO:0010592
GO:0016601
GO:0023052
GO:0031209
GO:0031267
GO:2000601
Participates
as a candidate of
RAC2 plasma membrane effectors [cytosol] (Canis familiaris)
RAC3 effectors [cytosol] (Canis familiaris)
as a component of
WAVE1 Regulatory Complex [cytosol] (Canis familiaris)
WAVE2 Regulatory Complex [cytosol] (Canis familiaris)
WAVE Regulatory Complex [cytosol] (Canis familiaris)
p-Y,S,T-WRC [cytosol] (Canis familiaris)
p-Y-WRC [cytosol] (Canis familiaris)
Inferred From
NCKAP1 [cytosol]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000061676
Ensembl
ENSCAFT00845028685
,
ENSCAFG00845016102
,
ENSCAFP00845022577
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