Reactome | TCF7L2 [nucleoplasm]

TCF7L2 [nucleoplasm]

Stable Identifier

R-CFA-201923

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

TCF7L2, A0A8I3Q5H3

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Canis familiaris)

- RNA Polymerase II Transcription (Canis familiaris)
  - Generic Transcription Pathway (Canis familiaris)
    - Transcriptional Regulation by VENTX (Canis familiaris)
      - VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Canis familiaris)
        
        CTNNB1:TCF7L2,LEF1:CCND1 Gene [nucleoplasm] (Canis familiaris)
        
        TCF/LEF:CTNNB1 [nucleoplasm] (Canis familiaris)
        
        TCF7L2,LEF1 [nucleoplasm] (Canis familiaris)
        
        TCF7L2 [nucleoplasm] (Canis familiaris)
        
        VENTX:TCF4,LEF1:CCND1 Gene [nucleoplasm] (Canis familiaris)
        
        TCF7L2,LEF1 [nucleoplasm] (Canis familiaris)
        
        TCF7L2 [nucleoplasm] (Canis familiaris)
    - Transcriptional regulation by RUNX3 (Canis familiaris)
      - RUNX3 regulates WNT signaling (Canis familiaris)
        
        RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Canis familiaris)
        
        CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Canis familiaris)
        
        TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Canis familiaris)
        
        TCF7L2 [nucleoplasm] (Canis familiaris)
        
        RUNX3:CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Canis familiaris)
        
        CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Canis familiaris)
        
        TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Canis familiaris)
        
        TCF7L2 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3Q5H3

Gene Names

TCF7L2

Reference Genes

ENSEMBL:ENSCAFG00845029959.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845029959.1 TCF7L2

Other Identifiers

486894

CfaAffx.17188.1.S1_s_at

CfaAffx.17195.1.S1_at

GO:0000122

GO:0000785

GO:0000976

GO:0000978

GO:0001568

GO:0003677

GO:0003700

GO:0005634

GO:0005654

GO:0005694

GO:0006351

GO:0006355

GO:0006357

GO:0006790

GO:0008013

GO:0010718

GO:0010909

GO:0016055

GO:0016922

GO:0019901

GO:0023052

GO:0030154

GO:0032024

GO:0032350

GO:0032993

GO:0042593

GO:0043226

GO:0043565

GO:0043570

GO:0045295

GO:0045444

GO:0045892

GO:0045944

GO:0048625

GO:0048660

GO:0048856

GO:0050679

GO:0051897

GO:0060070

GO:0061629

GO:0070016

GO:0070369

GO:0090090

GO:0140110

GO:1900182

GO:1901135

Participates

as a member of

as a candidate of

TCF7L1/TCF7L2/LEF1 [nucleoplasm] (Canis familiaris)

Other forms of this molecule

phospho-TCF7L2 [nucleoplasm]

Inferred From

TCF7L2 [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000148737

Ensembl

ENSCAFT00845053331, ENSCAFP00845041889, ENSCAFG00845029959

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