Reactome | phospho-LCP2 [cytosol]

phospho-LCP2 [cytosol]

Stable Identifier

R-CFA-202175

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

p-Y113,128,145-LCP2, A0A8I3MGV8

Locations in the PathwayBrowser

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Immune System (Canis familiaris)

- Adaptive Immune System (Canis familiaris)
  - TCR signaling (Canis familiaris)
    - Generation of second messenger molecules (Canis familiaris)
      - Disassociation of PLC-gamma1 from SLP-76 (Canis familiaris)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
        
        phosphorylated PLC-gamma1 bound to SLP-76 [plasma membrane] (Canis familiaris)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
      - NCK binds PAK (Canis familiaris)
        
        p-SLP-76:NCK1 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
        
        p-SLP-76:NCK:PAK [cytosol] (Canis familiaris)
        
        p-SLP-76:NCK1 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
      - Phosphorylation of PLC-gamma1 (Canis familiaris)
        
        PLC-gamma1 bound to LAT or SLP-76 [plasma membrane] (Canis familiaris)
        
        PLCG1:p-3Y-SLP-76:Gads:LAT [plasma membrane] (Canis familiaris)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
        
        Phosphorylated PLC-gamma1 bound to LAT or SLP-76 [plasma membrane] (Canis familiaris)
        
        phosphorylated PLC-gamma1 bound to SLP-76 [plasma membrane] (Canis familiaris)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
        
        ZAP-70 and ITK tyrosine kinases [plasma membrane] (Canis familiaris)
        
        ITK:p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Canis familiaris)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
      - Phosphorylation of SLP-76 (Canis familiaris)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
      - Recruitment of ITK to SLP-76 (Canis familiaris)
        
        ITK:p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Canis familiaris)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
      - Recruitment of PLC-gamma1 to SLP-76 (Canis familiaris)
        
        PLCG1:p-3Y-SLP-76:Gads:LAT [plasma membrane] (Canis familiaris)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
      - p-SLP-76 binds ADAP (Canis familiaris)
        
        p-SLP-76:ADAP [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
      - p-SLP-76 binds NCK (Canis familiaris)
        
        p-SLP-76:NCK1 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
- Innate Immune System (Canis familiaris)
  - DAP12 interactions (Canis familiaris)
    - DAP12 signaling (Canis familiaris)
      - Activation of RAC1 by VAV2/3 (Canis familiaris)
        
        p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
      - Phosphorylation and activation of VAV2/VAV3 by SYK (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
        
        p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
      - Phosphorylation of BTK by p-SYK (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
      - Phosphorylation of PLC-gamma by p-BTK/p-SYK (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Canis familiaris)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
        
        p-SYK/p-BTK [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
      - Phosphorylation of SLP-76 by p-SYK (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
      - Recruitment of VAV and BTK to p-SLP-76 (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
      - Release of p-PLCG1 (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Canis familiaris)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Canis familiaris)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
  - Fc epsilon receptor (FCERI) signaling (Canis familiaris)
    - FCERI mediated Ca+2 mobilization (Canis familiaris)
      - Autophosphorylation of BTK/ITK (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
      - Hydrolysis of PIP2 by PLCG (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Canis familiaris)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
      - Phosphorylation of TEC kinases by p-SYK (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
    - FCERI mediated MAPK activation (Canis familiaris)
      - Activation of RAC1 by VAV (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
      - Autophosphorylation of PAK (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
      - Phosphorylation and activation of VAV (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
      - Phosphorylation of SLP-76 by p-SYK (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
      - Recruitment of PAK to the membrane by binding active RAC1 (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
      - Recruitment of VAV to p-SLP-76 (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Canis familiaris)
        
        phospho-LCP2 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3MGV8

Gene Names

LCP2

Reference Genes

BioGPS Gene:489126 LCP2

ENSEMBL:ENSCAFG00845002557.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845002557.1 LCP2

KEGG Gene (Canis lupus familiaris):489126 LCP2

Monarch:489126 LCP2

NCBI Gene:489126 LCP2

Reference Transcript

RefSeq:XM_005619220.2 LCP2

Other Identifiers

489126

Cfa.18362.1.S1_at

Cfa.21232.1.S1_s_at

CfaAffx.25942.1.S1_at

CfaAffx.25943.1.S1_s_at

GO:0002376

GO:0005515

GO:0005829

GO:0005886

GO:0005911

GO:0023052

GO:0036398

GO:0044853

GO:0045576

GO:0050852

Participates

as an input of

as a component of

as an output of

Syk activation leads to SLP-76 activation (Canis familiaris)

This entity regulates

Positively

SLP-76 stimulates PLC gamma 2 (Canis familiaris)

Other forms of this molecule

LCP2 [cytosol]

Inferred From

p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 113 (in Homo sapiens)

Coordinate

113

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 128 (in Homo sapiens)

Coordinate

128

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 145 (in Homo sapiens)

Coordinate

145

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_005619277.1

OpenTargets

ENSG00000043462

Ensembl

ENSCAFP00845003626, ENSCAFG00845002557, ENSCAFT00845004539

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