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phospho-LCK [cytosol]
Stable Identifier
R-CFA-202308
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
p-Y394-LCK, A0A8I3NAC6
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Costimulation by the CD28 family (Canis familiaris)
PD-1 signaling (Canis familiaris)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Canis familiaris)
Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Canis familiaris)
phospho-LCK [cytosol] (Canis familiaris)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
phospho-LCK [cytosol] (Canis familiaris)
TCR signaling (Canis familiaris)
Downstream TCR signaling (Canis familiaris)
Change of PKC theta conformation (Canis familiaris)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Canis familiaris)
phospho-LCK [cytosol] (Canis familiaris)
Generation of second messenger molecules (Canis familiaris)
Phosphorylation of PLC-gamma1 (Canis familiaris)
ZAP-70 and ITK tyrosine kinases [plasma membrane] (Canis familiaris)
Activated ZAP-70 [plasma membrane] (Canis familiaris)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
phospho-LCK [cytosol] (Canis familiaris)
Phosphorylation of SLP-76 (Canis familiaris)
Activated ZAP-70 [plasma membrane] (Canis familiaris)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
phospho-LCK [cytosol] (Canis familiaris)
Phosphorylation of TBSMs in LAT (Canis familiaris)
Activated ZAP-70 [plasma membrane] (Canis familiaris)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
phospho-LCK [cytosol] (Canis familiaris)
Phosphorylation of CD3 and TCR zeta chains (Canis familiaris)
Activation of Lck (Canis familiaris)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Canis familiaris)
phospho-LCK [cytosol] (Canis familiaris)
Inactivation of LCK by PTPN22 (Canis familiaris)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Canis familiaris)
phospho-LCK [cytosol] (Canis familiaris)
Phosphorylation of ITAM motifs in CD3 complexes (Canis familiaris)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Canis familiaris)
phospho-LCK [cytosol] (Canis familiaris)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
phospho-LCK [cytosol] (Canis familiaris)
phospho-LCK [cytosol] (Canis familiaris)
Translocation of ZAP-70 to Immunological synapse (Canis familiaris)
Activation of ZAP-70 (Canis familiaris)
Activated ZAP-70 [plasma membrane] (Canis familiaris)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
phospho-LCK [cytosol] (Canis familiaris)
phospho tyrosine ZAP-70 [plasma membrane] (Canis familiaris)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
phospho-LCK [cytosol] (Canis familiaris)
PTPN22 dephosphorylates ZAP70 (Canis familiaris)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Canis familiaris)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
phospho-LCK [cytosol] (Canis familiaris)
phospho tyrosine ZAP-70 [plasma membrane] (Canis familiaris)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
phospho-LCK [cytosol] (Canis familiaris)
Phosphorylation of ZAP-70 by Lck (Canis familiaris)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Canis familiaris)
phospho-LCK [cytosol] (Canis familiaris)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Canis familiaris)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
phospho-LCK [cytosol] (Canis familiaris)
phospho tyrosine ZAP-70 [plasma membrane] (Canis familiaris)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
phospho-LCK [cytosol] (Canis familiaris)
Recruitment of ZAP-70 to phosphorylated ITAMs (Canis familiaris)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
phospho-LCK [cytosol] (Canis familiaris)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Canis familiaris)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
phospho-LCK [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3NAC6
Gene Names
LCK
Reference Genes
BioGPS Gene:478151 LCK
ENSEMBL:ENSCAFG00845004976.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845004976.1 LCK
KEGG Gene (Canis lupus familiaris):478151 LCK
Monarch:478151 LCK
NCBI Gene:478151 LCK
Reference Transcript
RefSeq:XM_005617639.1 LCK
Other Identifiers
478151
Cfa.18965.1.S1_s_at
CfaAffx.16646.1.S1_at
GO:0000242
GO:0001772
GO:0001784
GO:0002376
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0004722
GO:0005515
GO:0005524
GO:0005815
GO:0005856
GO:0005886
GO:0006468
GO:0006882
GO:0006919
GO:0007155
GO:0009410
GO:0012501
GO:0016004
GO:0016740
GO:0016787
GO:0018108
GO:0019901
GO:0019903
GO:0023052
GO:0030154
GO:0030217
GO:0034116
GO:0035556
GO:0036211
GO:0038083
GO:0038094
GO:0042169
GO:0042608
GO:0042609
GO:0042610
GO:0042802
GO:0043226
GO:0043274
GO:0043548
GO:0045121
GO:0048856
GO:0050870
GO:0051117
GO:0055065
GO:0098772
GO:0140096
GO:1903039
GO:2001244
Participates
as a component of
Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Canis familiaris)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Canis familiaris)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
Other forms of this molecule
phospho-LCK [plasma membrane]
phospho-LCK [plasma membrane]
LCK [cytosol]
Inferred From
p-Y394-LCK [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 394 (in Homo sapiens)
Coordinate
394
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
XP_005617696.1
OpenTargets
ENSG00000182866
Ensembl
ENSCAFG00845004976
,
ENSCAFT00845008902
,
ENSCAFP00845007011
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