Reactome | DUSP4 [nucleoplasm]

DUSP4 [nucleoplasm]

Stable Identifier

R-CFA-203794

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

DUSP4, A0A8I3NYF2

Locations in the PathwayBrowser

Expand all

Immune System (Canis familiaris)

- Cytokine Signaling in Immune system (Canis familiaris)
  - Signaling by Interleukins (Canis familiaris)
    - Interleukin-17 signaling (Canis familiaris)
      - MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        ERK/MAPK targets (Canis familiaris)
        
        ERKs are inactivated (Canis familiaris)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
        
        ERK-specific DUSP [nucleoplasm] (Canis familiaris)
        
        DUSP4 [nucleoplasm] (Canis familiaris)
- Innate Immune System (Canis familiaris)
  - Toll-like Receptor Cascades (Canis familiaris)
    - Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
      - MyD88 cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        ERK/MAPK targets (Canis familiaris)
        
        ERKs are inactivated (Canis familiaris)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
        
        ERK-specific DUSP [nucleoplasm] (Canis familiaris)
        
        DUSP4 [nucleoplasm] (Canis familiaris)
    - Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
      - Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        ERK/MAPK targets (Canis familiaris)
        
        ERKs are inactivated (Canis familiaris)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
        
        ERK-specific DUSP [nucleoplasm] (Canis familiaris)
        
        DUSP4 [nucleoplasm] (Canis familiaris)
      - Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        ERK/MAPK targets (Canis familiaris)
        
        ERKs are inactivated (Canis familiaris)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
        
        ERK-specific DUSP [nucleoplasm] (Canis familiaris)
        
        DUSP4 [nucleoplasm] (Canis familiaris)
    - Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
      - MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        ERK/MAPK targets (Canis familiaris)
        
        ERKs are inactivated (Canis familiaris)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
        
        ERK-specific DUSP [nucleoplasm] (Canis familiaris)
        
        DUSP4 [nucleoplasm] (Canis familiaris)
    - Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
      - MyD88-independent TLR4 cascade (Canis familiaris)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        ERK/MAPK targets (Canis familiaris)
        
        ERKs are inactivated (Canis familiaris)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
        
        ERK-specific DUSP [nucleoplasm] (Canis familiaris)
        
        DUSP4 [nucleoplasm] (Canis familiaris)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        ERK/MAPK targets (Canis familiaris)
        
        ERKs are inactivated (Canis familiaris)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
        
        ERK-specific DUSP [nucleoplasm] (Canis familiaris)
        
        DUSP4 [nucleoplasm] (Canis familiaris)
    - Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
      - MyD88 cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        ERK/MAPK targets (Canis familiaris)
        
        ERKs are inactivated (Canis familiaris)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
        
        ERK-specific DUSP [nucleoplasm] (Canis familiaris)
        
        DUSP4 [nucleoplasm] (Canis familiaris)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
      - MyD88 dependent cascade initiated on endosome (Canis familiaris)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        ERK/MAPK targets (Canis familiaris)
        
        ERKs are inactivated (Canis familiaris)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
        
        ERK-specific DUSP [nucleoplasm] (Canis familiaris)
        
        DUSP4 [nucleoplasm] (Canis familiaris)
    - Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
      - MyD88 dependent cascade initiated on endosome (Canis familiaris)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        ERK/MAPK targets (Canis familiaris)
        
        ERKs are inactivated (Canis familiaris)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
        
        ERK-specific DUSP [nucleoplasm] (Canis familiaris)
        
        DUSP4 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NYF2

Gene Names

DUSP4

Reference Genes

ENSEMBL:ENSCAFG00845012846.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845012846.1 DUSP4

Other Identifiers

119881767

CfaAffx.10836.1.S1_s_at

GO:0003824

GO:0004721

GO:0005634

GO:0006470

GO:0008138

GO:0016311

GO:0016787

GO:0016791

GO:0017017

GO:0036211

GO:0043226

GO:0140096

Participates

as a candidate of

nuclear MAPK DUSPs [nucleoplasm] (Canis familiaris)

as a member of

ERK-specific DUSP [nucleoplasm] (Canis familiaris)

Inferred From

DUSP4 [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000120875

Ensembl

ENSCAFG00845012846, ENSCAFP00845017921, ENSCAFT00845022860

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