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ROCK1 [cytosol]
Stable Identifier
R-CFA-212509
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
A0A8I3MEB5
Locations in the PathwayBrowser
Expand all
Developmental Biology (Canis familiaris)
Nervous system development (Canis familiaris)
Axon guidance (Canis familiaris)
EPH-Ephrin signaling (Canis familiaris)
EPHB-mediated forward signaling (Canis familiaris)
RHOA:GTP binds ROCK, activating it (Canis familiaris)
RHOA:GTP:ROCK1,ROCK2 [plasma membrane] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
Semaphorin interactions (Canis familiaris)
Sema4D in semaphorin signaling (Canis familiaris)
Sema4D induced cell migration and growth-cone collapse (Canis familiaris)
ROCK activation by RHO (Canis familiaris)
Activated ROCK:RhoA/B/C:GTP [plasma membrane] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
ROCK1,ROCK2:ROCKi [cytosol] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
ROCK1,2 bind ROCKi (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
ROCK1,ROCK2:ROCKi [cytosol] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
Programmed Cell Death (Canis familiaris)
Apoptosis (Canis familiaris)
Apoptotic execution phase (Canis familiaris)
Apoptotic cleavage of cellular proteins (Canis familiaris)
Caspase-mediated cleavage of Rock-1 (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (12/13) signalling events (Canis familiaris)
ROCK activation by RHO (Canis familiaris)
Activated ROCK:RhoA/B/C:GTP [plasma membrane] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
ROCK1,ROCK2:ROCKi [cytosol] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
ROCK1,2 bind ROCKi (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
ROCK1,ROCK2:ROCKi [cytosol] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by VEGF (Canis familiaris)
VEGFA-VEGFR2 Pathway (Canis familiaris)
Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Canis familiaris)
RHOA:GTP:Mg2+:Activated ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Canis familiaris)
RHOA:GTP:ROCK1,ROCK2 [plasma membrane] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
ROCK1,ROCK2 are activated (Canis familiaris)
RHOA:GTP:Mg2+:Activated ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
RHOA:GTP:ROCK1,ROCK2 [plasma membrane] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase Effectors (Canis familiaris)
RHO GTPases Activate ROCKs (Canis familiaris)
ROCK activation by RHO (Canis familiaris)
Activated ROCK:RhoA/B/C:GTP [plasma membrane] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
ROCK1,ROCK2:ROCKi [cytosol] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
ROCK1,2 bind ROCKi (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
ROCK1,ROCK2:ROCKi [cytosol] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
RHO GTPase cycle (Canis familiaris)
RHOA GTPase cycle (Canis familiaris)
RHOA binds effectors at the plasma membrane (Canis familiaris)
RHOA plasma membrane effectors [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
RHOA:GTP:cytosolic RHOA effectors [plasma membrane] (Canis familiaris)
RHOA plasma membrane effectors [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
RHOB GTPase cycle (Canis familiaris)
RHOB binds effectors at the plasma membrane (Canis familiaris)
RHOB effectors (plasma membrane) [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
RHOB:GTP:cytosolic RHOB effectors [plasma membrane] (Canis familiaris)
RHOB effectors (plasma membrane) [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
RHOBTB GTPase Cycle (Canis familiaris)
RHOBTB1 GTPase cycle (Canis familiaris)
RHOBTB1 binds interacting proteins at the endosome membrane (Canis familiaris)
RHOBTB1 interacting proteins [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
RHOBTB1:GTP:RHOBTB1 interacting proteins [endosome membrane] (Canis familiaris)
RHOBTB1 interacting proteins [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
RHOC GTPase cycle (Canis familiaris)
RHOC binds effectors at the plasma membrane (Canis familiaris)
RHOC effectors [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
RHOC:GTP:RHOC effectors [plasma membrane] (Canis familiaris)
RHOC effectors [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
RHOH GTPase cycle (Canis familiaris)
RHOH binds effectors at the plasma membrane (Canis familiaris)
RHOH effectors [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
RHOH:GTP:RHOH effectors [plasma membrane] (Canis familiaris)
RHOH effectors [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
RND3 GTPase cycle (Canis familiaris)
RND3 binds effectors (Canis familiaris)
RND3 effectors [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
RND3:GTP:RND3 effectors [plasma membrane] (Canis familiaris)
RND3 effectors [cytosol] (Canis familiaris)
ROCK1 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3MEB5
Reference Genes
ENSEMBL:ENSCAFG00845001454.1
UCSC:A0A8I3MEB5
Other Identifiers
Cfa.16136.1.A1_at
CfaAffx.27992.1.S1_s_at
CfaAffx.28002.1.S1_at
GO:0000139
GO:0001726
GO:0001837
GO:0002376
GO:0003013
GO:0003383
GO:0003824
GO:0004674
GO:0005524
GO:0005794
GO:0005814
GO:0005856
GO:0005886
GO:0007010
GO:0007155
GO:0007159
GO:0007249
GO:0007266
GO:0010494
GO:0010508
GO:0010613
GO:0010628
GO:0012501
GO:0016525
GO:0016740
GO:0022614
GO:0030027
GO:0030036
GO:0030154
GO:0030334
GO:0030866
GO:0031175
GO:0031267
GO:0032059
GO:0032060
GO:0032956
GO:0032970
GO:0035306
GO:0042995
GO:0043226
GO:0043410
GO:0045616
GO:0045664
GO:0046872
GO:0048870
GO:0050900
GO:0050901
GO:0051451
GO:0051894
GO:0061157
GO:0070507
GO:0071559
GO:0072518
GO:0072659
GO:0090128
GO:0090521
GO:0097049
GO:0097746
GO:0098685
GO:0110061
GO:0140058
GO:0140096
GO:1900223
GO:1900242
GO:1902430
GO:1902992
GO:1903140
GO:1903347
GO:1905205
GO:1990776
GO:2000672
Participates
as a member of
RHOA plasma membrane effectors [cytosol] (Canis familiaris)
RND3 effectors [cytosol] (Canis familiaris)
RHOC effectors [cytosol] (Canis familiaris)
RHOBTB1 interacting proteins [cytosol] (Canis familiaris)
RHOB effectors (plasma membrane) [cytosol] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
as a candidate of
RHOH effectors [cytosol] (Canis familiaris)
as an input of
Caspase-mediated cleavage of Rock-1 (Canis familiaris)
Other forms of this molecule
ROCK1 [extracellular region]
ROCK1 [secretory granule lumen]
ROCK1(1114-1354) [cytosol]
ROCK1(1-1113) [cytosol]
Inferred From
Activated ROCK1 [cytosol]
(Homo sapiens)
ROCK1 [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSCAFT00845002571
,
ENSCAFP00845002048
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