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phospho-p-T179,S423,S425-SMAD3 [nucleoplasm]
Stable Identifier
R-CFA-2176471
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
nucleoplasm
Synonyms
F1PSQ3
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Canis familiaris)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Canis familiaris)
Degradation of SMAD2/3:SMAD4 complex (Canis familiaris)
Ub-p-T-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD3:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
NEDD4L binds phosphorylated linker region of SMAD2/3 (Canis familiaris)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD3:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
p-T-2S-SMAD2,3:SMAD4:NEDDL4 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD3:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
NEDD4L ubiquitinates SMAD2/3 (Canis familiaris)
Ub-p-T-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD3:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
p-T-2S-SMAD2,3:SMAD4:NEDDL4 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD3:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
SMURF2 binds SMAD3 phosphorylated in the linker region (Canis familiaris)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD3:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
p-T-2S-SMAD2,3:SMAD4:SMURF2 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD3:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
SMURF2 monoubiquitinates SMAD3 (Canis familiaris)
p-T-2S-SMAD2,3:SMAD4:SMURF2 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD3:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Canis familiaris)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Canis familiaris)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD3:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by TGFB family members (Canis familiaris)
Signaling by TGF-beta Receptor Complex (Canis familiaris)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Canis familiaris)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Canis familiaris)
Degradation of SMAD2/3:SMAD4 complex (Canis familiaris)
Ub-p-T-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD3:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
NEDD4L binds phosphorylated linker region of SMAD2/3 (Canis familiaris)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD3:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
p-T-2S-SMAD2,3:SMAD4:NEDDL4 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD3:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
NEDD4L ubiquitinates SMAD2/3 (Canis familiaris)
Ub-p-T-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD3:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
p-T-2S-SMAD2,3:SMAD4:NEDDL4 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD3:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
SMURF2 binds SMAD3 phosphorylated in the linker region (Canis familiaris)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD3:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
p-T-2S-SMAD2,3:SMAD4:SMURF2 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD3:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
SMURF2 monoubiquitinates SMAD3 (Canis familiaris)
p-T-2S-SMAD2,3:SMAD4:SMURF2 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD3:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Canis familiaris)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Canis familiaris)
p-T,2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD3:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm] (Canis familiaris)
External Reference Information
External Reference
UniProt:F1PSQ3
Reference Genes
ENSEMBL:ENSCAFG00000017388
Participates
as a component of
p-T,2S-SMAD3:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
p-T,2S-SMAD2:p-T,2S-SMAD3:SMAD4 [nucleoplasm] (Canis familiaris)
Other forms of this molecule
Ub-SMAD3 [cytosol]
phospho-p-S208-SMAD3 [cytosol]
SMAD3 [nucleoplasm]
phospho-2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
phospho-Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
SMAD3 [cytosol]
phospho-p-S423,S425-SMAD3 [cytosol]
phospho-p-S423,S425-SMAD3 [nucleoplasm]
Inferred From
p-T179,S423,S425-SMAD3 [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 423 (in Homo sapiens)
Coordinate
423
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 425 (in Homo sapiens)
Coordinate
425
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 179 (in Homo sapiens)
Coordinate
179
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
VGNC
46520
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