Reactome | phospho-IRS4 [plasma membrane]

phospho-IRS4 [plasma membrane]

Stable Identifier

R-CFA-2424302

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

p-Y-IRS4, E2RLU4

Locations in the PathwayBrowser

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Signal Transduction (Canis familiaris)

- Signaling by Receptor Tyrosine Kinases (Canis familiaris)
  - Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Canis familiaris)
    - IGF1R signaling cascade (Canis familiaris)
      - IRS-related events triggered by IGF1R (Canis familiaris)
        
        IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Canis familiaris)
        
        IGF1,2:p-IGF1R:p-IRS1,2,4 [plasma membrane] (Canis familiaris)
        
        p-IRS1,2,4 [plasma membrane] (Canis familiaris)
        
        phospho-IRS4 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:E2RLU4

Gene Names

IRS4

Reference Genes

BioGPS Gene:492059 IRS4

ENSEMBL:ENSCAFG00000018028

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000018028 IRS4

Monarch:492059 IRS4

NCBI Gene:492059 IRS4

Reference Transcript

RefSeq:XM_005641658.1 IRS4

Other Identifiers

492059

CfaAffx.27613.1.S1_at

GO:0003674

GO:0005158

GO:0007165

GO:0008150

GO:0008286

Participant Of

hasMember

p-IRS1,2,4 [plasma membrane]

Other forms of this molecule

IRS4 [plasma membrane]

Inferred From

p-Y-IRS4 [plasma membrane] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_005641715.1

OpenTargets

ENSG00000133124

Ensembl

ENSCAFG00000018028, ENSCAFP00000026634, ENSCAFT00000028636

VGNC

42100

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