Reactome | phospho-IRS4 [plasma membrane]

phospho-IRS4 [plasma membrane]

Stable Identifier

R-CFA-2424302

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

p-Y-IRS4, A0A8I3PAR4

Locations in the PathwayBrowser

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Signal Transduction (Canis familiaris)

- Signaling by Receptor Tyrosine Kinases (Canis familiaris)
  - Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Canis familiaris)
    - IGF1R signaling cascade (Canis familiaris)
      - IRS-related events triggered by IGF1R (Canis familiaris)
        
        IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Canis familiaris)
        
        IGF1,2:p-IGF1R:p-IRS1,2,4 [plasma membrane] (Canis familiaris)
        
        p-IRS1,2,4 [plasma membrane] (Canis familiaris)
        
        phospho-IRS4 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3PAR4

Gene Names

IRS4

Reference Genes

ENSEMBL:ENSCAFG00845020997.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845020997.1 IRS4

Reference Transcript

RefSeq:XM_014112002.1 IRS4

Other Identifiers

492059

CfaAffx.27613.1.S1_at

GO:0005158

GO:0008286

GO:0023052

Participates

as a member of

p-IRS1,2,4 [plasma membrane] (Canis familiaris)

Other forms of this molecule

IRS4 [plasma membrane]

Inferred From

p-Y-IRS4 [plasma membrane] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_013967477.1

OpenTargets

ENSG00000133124

Ensembl

ENSCAFG00845020997, ENSCAFT00845037065, ENSCAFP00845029026

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