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p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane]
Stable Identifier
R-CFA-2424468
Type
Complex
Species
Canis familiaris
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Innate Immune System (Canis familiaris)
DAP12 interactions (Canis familiaris)
DAP12 signaling (Canis familiaris)
Activation of RAC1 by VAV2/3 (Canis familiaris)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Phosphorylation and activation of VAV2/VAV3 by SYK (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Phosphorylation of BTK by p-SYK (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
p-SYK/p-BTK [plasma membrane] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Phosphorylation of SLP-76 by p-SYK (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Recruitment of GADS:SLP-76 to p-5Y-LAT (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Recruitment of GRB2:SOS to p-5Y-LAT (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Recruitment of VAV and BTK to p-SLP-76 (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Release of p-PLCG1 (Canis familiaris)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
SOS mediated nucleotide exchange of RAS (SHC) (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated Ca+2 mobilization (Canis familiaris)
Autophosphorylation of BTK/ITK (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Hydrolysis of PIP2 by PLCG (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Phosphorylation of TEC kinases by p-SYK (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
FCERI mediated MAPK activation (Canis familiaris)
Activation of RAC1 by VAV (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Autophosphorylation of PAK (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Phosphorylation and activation of VAV (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Phosphorylation of SLP-76 by p-SYK (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Recruitment of GADS:SLP-76 to p-5Y-LAT (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Recruitment of GRB2:SOS to p-5Y-LAT (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Recruitment of PAK to the membrane by binding active RAC1 (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Recruitment of VAV to p-SLP-76 (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
SOS mediated nucleotide exchange of RAS (SHC) (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Signal Transduction (Canis familiaris)
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
RAS GEFs promote RAS nucleotide exchange (Canis familiaris)
RAS GEFs [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
p-SHC1:GRB2:SOS [cytosol]
(Canis familiaris)
phospho-LAT [plasma membrane]
(Canis familiaris)
Participates
as a component of
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
as an input of
Recruitment of GADS:SLP-76 to p-5Y-LAT (Canis familiaris)
as an output of
Recruitment of GRB2:SOS to p-5Y-LAT (Canis familiaris)
as a member of
RAS GEFs [plasma membrane] (Canis familiaris)
Inferred From
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane]
(Homo sapiens)
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