Reactome | FCN1 [extracellular region]

FCN1 [extracellular region]

Stable Identifier

R-CFA-2530438

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

extracellular region

Synonyms

FCN2, J9P7F7

Locations in the PathwayBrowser

Expand all

Immune System (Canis familiaris)

- Innate Immune System (Canis familiaris)
  - Complement cascade (Canis familiaris)
    - Initial triggering of complement (Canis familiaris)
      - Conversion of C2 into C2a and C2b (Canis familiaris)
        
        C4 activators [plasma membrane] (Canis familiaris)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Canis familiaris)
        
        Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Canis familiaris)
        
        FCN2 dodecamer [extracellular region] (Canis familiaris)
        
        FCN2 trimer [extracellular region] (Canis familiaris)
        
        FCN1 [extracellular region] (Canis familiaris)
      - Conversion of C4 into C4a and C4b (Canis familiaris)
        
        C4 activators [plasma membrane] (Canis familiaris)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Canis familiaris)
        
        Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Canis familiaris)
        
        FCN2 dodecamer [extracellular region] (Canis familiaris)
        
        FCN2 trimer [extracellular region] (Canis familiaris)
        
        FCN1 [extracellular region] (Canis familiaris)
      - Creation of C4 and C2 activators (Canis familiaris)
        
        Lectin pathway of complement activation (Canis familiaris)
        
        Activation of MASPs (Canis familiaris)
        
        MBL2,FCN:MASPs:carbohydrate patterns [plasma membrane] (Canis familiaris)
        
        FCN2 ligands:FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Canis familiaris)
        
        FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Canis familiaris)
        
        FCN2 dodecamer [extracellular region] (Canis familiaris)
        
        FCN2 trimer [extracellular region] (Canis familiaris)
        
        FCN1 [extracellular region] (Canis familiaris)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Canis familiaris)
        
        Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Canis familiaris)
        
        FCN2 dodecamer [extracellular region] (Canis familiaris)
        
        FCN2 trimer [extracellular region] (Canis familiaris)
        
        FCN1 [extracellular region] (Canis familiaris)
        
        Ficolins bind to repetitive carbohydrate structures on the target cell surface (Canis familiaris)
        
        Ficolin-2 binds to molecular patterns on the target cell surface (Canis familiaris)
        
        FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Canis familiaris)
        
        FCN2 dodecamer [extracellular region] (Canis familiaris)
        
        FCN2 trimer [extracellular region] (Canis familiaris)
        
        FCN1 [extracellular region] (Canis familiaris)
        
        FCN2 ligands:FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] (Canis familiaris)
        
        FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Canis familiaris)
        
        FCN2 dodecamer [extracellular region] (Canis familiaris)
        
        FCN2 trimer [extracellular region] (Canis familiaris)
        
        FCN1 [extracellular region] (Canis familiaris)

External Reference Information

External Reference

UniProt:J9P7F7

Gene Names

FCN1

Reference Genes

BioGPS Gene:608247 FCN1

ENSEMBL:ENSCAFG00000030630

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000030630 FCN1

Monarch:608247 FCN1

NCBI Gene:608247 FCN1

Reference Transcript

RefSeq:XM_845214.2 FCN1

Other Identifiers

608247

Cfa.13207.1.A1_s_at

CfaAffx.30397.1.S1_at

GO:0001867

GO:0002376

GO:0003674

GO:0003823

GO:0005102

GO:0005575

GO:0005576

GO:0005615

GO:0006950

GO:0008150

GO:0031012

GO:0062023

GO:0097367

Participates

as a component of

FCN2 trimer [extracellular region] (Canis familiaris)

Other forms of this molecule

FCN1 [ficolin-1-rich granule lumen]

FCN1 [secretory granule lumen]

FCN1 [extracellular region]

Inferred From

FCN2 [extracellular region] (Homo sapiens)

Cross References

RefSeq

XP_850307.1

OpenTargets

ENSG00000085265

Ensembl

ENSCAFG00000030630, ENSCAFP00000041594, ENSCAFT00000043238

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