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CRK [cytosol]
Stable Identifier
R-CFA-2980677
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
A0A8I3NGQ0
Locations in the PathwayBrowser
Expand all
Hemostasis (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
Platelet Aggregation (Plug Formation) (Canis familiaris)
Integrin signaling (Canis familiaris)
p130Cas linkage to MAPK signaling for integrins (Canis familiaris)
Crk binding to p130cas (Canis familiaris)
CRK [cytosol] (Canis familiaris)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Canis familiaris)
Regulation of signaling by CBL (Canis familiaris)
CBL binds CRK (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
p(Y700,731,774)-CBL:CRK [cytosol] (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
CBL:CRKL binds RAPGEF1 (Canis familiaris)
p(Y700,731,774)-CBL:CRK [cytosol] (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
p(Y700,731,774)-CBL:CRK:RAPGEF1 [cytosol] (Canis familiaris)
p(Y700,731,774)-CBL:CRK [cytosol] (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
Regulation of actin dynamics for phagocytic cup formation (Canis familiaris)
Activation of RAC1 by CRKII:DOCK180:ELMO (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Integrin signaling (Canis familiaris)
p130Cas linkage to MAPK signaling for integrins (Canis familiaris)
Crk binding to p130cas (Canis familiaris)
CRK [cytosol] (Canis familiaris)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
Signaling by Non-Receptor Tyrosine Kinases (Canis familiaris)
Signaling by PTK6 (Canis familiaris)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Canis familiaris)
Activation of RAC1 by the PXN:CRK complex (Canis familiaris)
p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
Phosphorylated PXN recruits the CRK complex (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by MET (Canis familiaris)
MET promotes cell motility (Canis familiaris)
MET activates RAP1 and RAC1 (Canis familiaris)
CRK,CRKL recruits RAC1 GEF to activated MET (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
DOCK7 activates RAC1 (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
GAB1 recruits CRK,CRKL to MET (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
RAPGEF1 activates RAP1 (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
RAPGEF1 binds CRK,CRKL (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
MET receptor recycling (Canis familiaris)
GGA3 associates with activated MET receptor (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
Signaling by NTRKs (Canis familiaris)
Signaling by NTRK1 (TRKA) (Canis familiaris)
Signalling to ERKs (Canis familiaris)
Prolonged ERK activation events (Canis familiaris)
ARMS-mediated activation (Canis familiaris)
ARMS is phosphorylated by active TrkA receptor (Canis familiaris)
Active TrkA receptor:ARMS:Crk complex [plasma membrane] (Canis familiaris)
ARMS:Crk [cytosol] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Canis familiaris)
Phospho-ARMS:Crk [cytosol] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
C3G stimulates nucleotide exchange on Rap1 (Canis familiaris)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Canis familiaris)
Phospho-ARMS:Crk [cytosol] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
Crk's SH3 domain engages C3G (Canis familiaris)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Canis familiaris)
Phospho-ARMS:Crk [cytosol] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
Signaling by PDGF (Canis familiaris)
Downstream signal transduction (Canis familiaris)
Crk binds to the active PDGF receptor (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
p130Cas and C3G bind PDGFR bound Crk (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3G [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Canis familiaris)
CRK, CRKL [cytosol] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
Signaling by VEGF (Canis familiaris)
VEGFA-VEGFR2 Pathway (Canis familiaris)
CRK binds BCAR1 and or PXN (Canis familiaris)
CRK [cytosol] (Canis familiaris)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
DOCK180:ELMO binds CRK (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
CRK [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3NGQ0
Reference Genes
ENSEMBL:ENSCAFG00845014106.1
UCSC:A0A8I3NGQ0
Other Identifiers
CfaAffx.29236.1.S1_at
GO:0001764
GO:0002376
GO:0002685
GO:0005737
GO:0005856
GO:0005886
GO:0006629
GO:0007163
GO:0007165
GO:0007167
GO:0008283
GO:0015629
GO:0016020
GO:0016358
GO:0016477
GO:0021766
GO:0021987
GO:0030010
GO:0030159
GO:0030971
GO:0031594
GO:0031625
GO:0032956
GO:0033628
GO:0035022
GO:0035591
GO:0035685
GO:0038026
GO:0043226
GO:0045309
GO:0046875
GO:0048856
GO:0048870
GO:0050773
GO:0060090
GO:0060326
GO:0098698
GO:0098749
GO:1902531
GO:1904395
GO:2000145
GO:2000404
Participates
as an input of
Crk binding to p130cas (Canis familiaris)
CRK binds BCAR1 and or PXN (Canis familiaris)
as a component of
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
Phospho-ARMS:Crk [cytosol] (Canis familiaris)
ARMS:Crk [cytosol] (Canis familiaris)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
as a member of
CRK, CRKL [cytosol] (Canis familiaris)
Inferred From
CRK [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSCAFP00845019834
,
ENSCAFT00845025221
,
ENSCAFG00845014106
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