Reactome | RPTOR [cytosol]

RPTOR [cytosol]

Stable Identifier

R-CFA-3006727

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

RPTOR, A0A8I3NME4

Locations in the PathwayBrowser

Expand all

Autophagy (Canis familiaris)

- Macroautophagy (Canis familiaris)
  - Active MTORC1 binds the ULK1 complex (Canis familiaris)
    - Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        RPTOR [cytosol] (Canis familiaris)
    - MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Canis familiaris)
      - Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        RPTOR [cytosol] (Canis familiaris)
  - Active MTORC1 phosphorylates ULK1 (Canis familiaris)
    - MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Canis familiaris)
      - Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        RPTOR [cytosol] (Canis familiaris)
    - MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Canis familiaris)
      - Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        RPTOR [cytosol] (Canis familiaris)
  - Rheb in the MTORC1 complex hydrolyses GTP (Canis familiaris)
    - Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        RPTOR [cytosol] (Canis familiaris)
    - mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Canis familiaris)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        RPTOR [cytosol] (Canis familiaris)
  - p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Canis familiaris)
    - MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Canis familiaris)
      - Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        RPTOR [cytosol] (Canis familiaris)

Cellular responses to stimuli (Canis familiaris)

- Cellular responses to stress (Canis familiaris)
  - Cellular response to starvation (Canis familiaris)
    - Amino acids regulate mTORC1 (Canis familiaris)
      - RRAGA,B hydrolyzes GTP (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        RPTOR [cytosol] (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        RPTOR [cytosol] (Canis familiaris)
      - mTORC1 binds RHEB:GTP (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        RPTOR [cytosol] (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        RPTOR [cytosol] (Canis familiaris)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        RPTOR [cytosol] (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        RPTOR [cytosol] (Canis familiaris)

Gene expression (Transcription) (Canis familiaris)

- RNA Polymerase II Transcription (Canis familiaris)
  - Generic Transcription Pathway (Canis familiaris)
    - Transcriptional Regulation by TP53 (Canis familiaris)
      - TP53 Regulates Metabolic Genes (Canis familiaris)
        
        RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Canis familiaris)
        
        Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        RPTOR [cytosol] (Canis familiaris)
        
        mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        RPTOR [cytosol] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Intracellular signaling by second messengers (Canis familiaris)
  - PIP3 activates AKT signaling (Canis familiaris)
    - PTEN Regulation (Canis familiaris)
      - Regulation of PTEN gene transcription (Canis familiaris)
        
        MAF1 translocates to the nucleus (Canis familiaris)
        
        Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        RPTOR [cytosol] (Canis familiaris)
        
        mTORC1 phosphorylates MAF1 (Canis familiaris)
        
        Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        RPTOR [cytosol] (Canis familiaris)
- MTOR signalling (Canis familiaris)
  - AKT1S1 (PRAS40) binds mTORC1 (Canis familiaris)
    - Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        RPTOR [cytosol] (Canis familiaris)
    - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Canis familiaris)
      - Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        RPTOR [cytosol] (Canis familiaris)
  - Energy dependent regulation of mTOR by LKB1-AMPK (Canis familiaris)
    - AMPK phosphorylates Raptor in the mTORC1 complex (Canis familiaris)
      - Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        RPTOR [cytosol] (Canis familiaris)
    - RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Canis familiaris)
      - Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        RPTOR [cytosol] (Canis familiaris)
      - mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        RPTOR [cytosol] (Canis familiaris)
  - Formation of active mTORC1 complex (Canis familiaris)
    - Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        RPTOR [cytosol] (Canis familiaris)
    - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
      - mTORC1 [cytosol] (Canis familiaris)
        
        RPTOR [cytosol] (Canis familiaris)
  - Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Canis familiaris)
    - mTORC1 [cytosol] (Canis familiaris)
      - RPTOR [cytosol] (Canis familiaris)
    - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
      - mTORC1 [cytosol] (Canis familiaris)
        
        RPTOR [cytosol] (Canis familiaris)
  - mTORC1 phosphorylates AKT1S1 (Canis familiaris)
    - mTORC1:RHEB:GTP:p-S183,T246-AKT1S1:YWHAB [lysosomal membrane] (Canis familiaris)
      - mTORC1:RHEB:GTP:p-S183,T246-AKT1S1 [lysosomal membrane] (Canis familiaris)
        
        Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        RPTOR [cytosol] (Canis familiaris)
    - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Canis familiaris)
      - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Canis familiaris)
        
        Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        RPTOR [cytosol] (Canis familiaris)
  - mTORC1-mediated signalling (Canis familiaris)
    - Phosphorylation of 4E-BP1 by activated mTORC1 (Canis familiaris)
      - Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        RPTOR [cytosol] (Canis familiaris)
      - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Canis familiaris)
        
        Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        RPTOR [cytosol] (Canis familiaris)
      - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Canis familiaris)
        
        mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Canis familiaris)
        
        Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        RPTOR [cytosol] (Canis familiaris)
    - mTORC1 phosphorylation of RPS6KB1 (S6K) (Canis familiaris)
      - Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        RPTOR [cytosol] (Canis familiaris)
      - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Canis familiaris)
        
        mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Canis familiaris)
        
        Active mTORC1 complex [lysosomal membrane] (Canis familiaris)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
        
        mTORC1 [cytosol] (Canis familiaris)
        
        RPTOR [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NME4

Gene Names

RPTOR

Reference Genes

BioGPS Gene:608378 RPTOR

ENSEMBL:ENSCAFG00845012286.1

Monarch:608378 RPTOR

NCBI Gene:608378 RPTOR

UCSC:A0A8I3NME4 RPTOR

Reference Transcript

RefSeq:XM_845394.4 RPTOR

Other Identifiers

CfaAffx.9497.1.S1_at

GO:0001558

GO:0005654

GO:0005737

GO:0005764

GO:0005765

GO:0005773

GO:0005829

GO:0006355

GO:0008361

GO:0009267

GO:0010494

GO:0010506

GO:0010507

GO:0010800

GO:0019901

GO:0030291

GO:0030295

GO:0030307

GO:0030674

GO:0031267

GO:0031669

GO:0031929

GO:0031931

GO:0032008

GO:0033138

GO:0038202

GO:0043226

GO:0044877

GO:0045945

GO:0060090

GO:0071230

GO:0071233

GO:0071333

GO:0071889

GO:0098772

GO:0140767

GO:1900087

Participates

as a component of

mTORC1 [cytosol] (Canis familiaris)

Other forms of this molecule

RPTOR [nucleoplasm]

phospho-RPTOR [cytosol]

Inferred From

RPTOR [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_850487.1

ENSEMBL

ENSCAFT00845022396, ENSCAFP00845017597

Cite Us!