Reactome | GATAD2A [nucleoplasm]

GATAD2A [nucleoplasm]

Stable Identifier

R-CFA-3702077

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

GATAD2A, A0A8I3NTF9

Locations in the PathwayBrowser

Expand all

Chromatin organization (Canis familiaris)

- Chromatin modifying enzymes (Canis familiaris)
  - HDACs deacetylate histones (Canis familiaris)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Canis familiaris)
      - HDAC1:2-containing complex [nucleoplasm] (Canis familiaris)
        
        NuRD complex [nucleoplasm] (Canis familiaris)
        
        (GATAD2A, GATAD2B) [nucleoplasm] (Canis familiaris)
        
        GATAD2A [nucleoplasm] (Canis familiaris)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Canis familiaris)
        
        HDAC1:2-containing complex [nucleoplasm] (Canis familiaris)
        
        NuRD complex [nucleoplasm] (Canis familiaris)
        
        (GATAD2A, GATAD2B) [nucleoplasm] (Canis familiaris)
        
        GATAD2A [nucleoplasm] (Canis familiaris)
    - HDAC1:2-containing complex deacetylate histones (Canis familiaris)
      - HDAC1:2-containing complex [nucleoplasm] (Canis familiaris)
        
        NuRD complex [nucleoplasm] (Canis familiaris)
        
        (GATAD2A, GATAD2B) [nucleoplasm] (Canis familiaris)
        
        GATAD2A [nucleoplasm] (Canis familiaris)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Canis familiaris)
        
        HDAC1:2-containing complex [nucleoplasm] (Canis familiaris)
        
        NuRD complex [nucleoplasm] (Canis familiaris)
        
        (GATAD2A, GATAD2B) [nucleoplasm] (Canis familiaris)
        
        GATAD2A [nucleoplasm] (Canis familiaris)

Gene expression (Transcription) (Canis familiaris)

- RNA Polymerase I Transcription (Canis familiaris)
  - RNA Polymerase I Promoter Clearance (Canis familiaris)
    - RNA Polymerase I Transcription Initiation (Canis familiaris)
      - Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Canis familiaris)
        
        TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Canis familiaris)
        
        NuRD complex [nucleoplasm] (Canis familiaris)
        
        (GATAD2A, GATAD2B) [nucleoplasm] (Canis familiaris)
        
        GATAD2A [nucleoplasm] (Canis familiaris)
- RNA Polymerase II Transcription (Canis familiaris)
  - Generic Transcription Pathway (Canis familiaris)
    - Transcriptional Regulation by TP53 (Canis familiaris)
      - Regulation of TP53 Activity (Canis familiaris)
        
        Regulation of TP53 Activity through Acetylation (Canis familiaris)
        
        MTA2-NuRD complex deacetylates TP53 (Canis familiaris)
        
        MTA2-NuRD complex [nucleoplasm] (Canis familiaris)
        
        (GATAD2A, GATAD2B) [nucleoplasm] (Canis familiaris)
        
        GATAD2A [nucleoplasm] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Intracellular signaling by second messengers (Canis familiaris)
  - PIP3 activates AKT signaling (Canis familiaris)
    - PTEN Regulation (Canis familiaris)
      - Regulation of PTEN gene transcription (Canis familiaris)
        
        SALL4 recruits NuRD to PTEN gene (Canis familiaris)
        
        NuRD complex [nucleoplasm] (Canis familiaris)
        
        (GATAD2A, GATAD2B) [nucleoplasm] (Canis familiaris)
        
        GATAD2A [nucleoplasm] (Canis familiaris)
        
        SALL4:NuRD:PTEN gene [nucleoplasm] (Canis familiaris)
        
        SALL4:NuRD [nucleoplasm] (Canis familiaris)
        
        NuRD complex [nucleoplasm] (Canis familiaris)
        
        (GATAD2A, GATAD2B) [nucleoplasm] (Canis familiaris)
        
        GATAD2A [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NTF9

Gene Names

GATAD2A

Reference Genes

ENSEMBL:ENSCAFG00845014383.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845014383.1 GATAD2A

Other Identifiers

484806

CfaAffx.22041.1.S1_at

CfaAffx.22041.1.S1_s_at

GO:0000122

GO:0003677

GO:0005634

GO:0005654

GO:0005694

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0016581

GO:0030674

GO:0043226

GO:0043565

GO:0045892

GO:0060090

Participates

as a candidate of

(GATAD2A, GATAD2B) [nucleoplasm] (Canis familiaris)

Inferred From

GATAD2A [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000167491

Ensembl

ENSCAFP00845020328, ENSCAFG00845014383, ENSCAFT00845025801