Reactome | GDNF [extracellular region]

GDNF [extracellular region]

Stable Identifier

R-CFA-375061

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

extracellular region

Synonyms

GDNF, A0A8I3MVS5

Locations in the PathwayBrowser

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Developmental Biology (Canis familiaris)

- Nervous system development (Canis familiaris)
  - Axon guidance (Canis familiaris)
    - RET signaling (Canis familiaris)
      - 2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:FRS2 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
      - 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
      - 2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB7,GRB10 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
      - 2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:PLCG1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
      - 2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:RET interactors [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
      - 2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
      - 2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:SRC-1,RAP1GAP [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
      - 2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:DOK1,DOK2,DOK4,DOK5,DOK6 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
      - 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
      - GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
      - GDNF,NRTN bind RET:GFRA1,GFRA2 (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
        
        RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
      - PKA phosphorylates RET:GDNF:GFRA dimer (Canis familiaris)
        
        2x RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
      - RET dimerizes (Canis familiaris)
        
        2x RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
        
        RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
      - RET tyrosine phosphorylation (Canis familiaris)
        
        2x RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
      - SHC1 in the RET complex is phosphorylated (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
      - p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
      - p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
      - p-5Y-RET complexes bind GRB2 (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
        
        p-5Y-RET:GDNF:GFRA complexes with and without p-SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
      - p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)

Signal Transduction (Canis familiaris)

- MAPK family signaling cascades (Canis familiaris)
  - MAPK1/MAPK3 signaling (Canis familiaris)
    - RAF/MAP kinase cascade (Canis familiaris)
      - RAS GEFs promote RAS nucleotide exchange (Canis familiaris)
        
        RAS GEFs [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        GDNF,NRTN [extracellular region] (Canis familiaris)
        
        GDNF [extracellular region] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3MVS5

Gene Names

GDNF

Reference Genes

ENSEMBL:ENSCAFG00845003744.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845003744.1 GDNF

Reference Transcript

Other Identifiers

119871563

CfaAffx.28524.1.S1_s_at

GO:0001656

GO:0001657

GO:0001658

GO:0001755

GO:0001759

GO:0001941

GO:0003012

GO:0003337

GO:0005576

GO:0005794

GO:0006351

GO:0006355

GO:0007165

GO:0007399

GO:0007422

GO:0008083

GO:0008284

GO:0010468

GO:0012501

GO:0016071

GO:0021516

GO:0021784

GO:0023052

GO:0030116

GO:0030154

GO:0030432

GO:0030971

GO:0031175

GO:0034330

GO:0042803

GO:0043226

GO:0043524

GO:0045597

GO:0045944

GO:0048018

GO:0048255

GO:0048484

GO:0048485

GO:0048568

GO:0048731

GO:0048856

GO:0048870

GO:0051584

GO:0060676

GO:0060688

GO:0061024

GO:0071679

GO:0072107

GO:0072108

GO:0090190

GO:0098772

GO:2001240

GO:2001260

Participates

as a member of

GDNF,NRTN [extracellular region] (Canis familiaris)

Inferred From

GDNF [extracellular region] (Homo sapiens)

Cross References

RefSeq

XP_546342.3, XP_005619435.1

OpenTargets

ENSG00000168621

Ensembl

ENSCAFT00845006692, ENSCAFP00845005324, ENSCAFG00845003744

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