Reactome | NDC80 [cytosol]

NDC80 [cytosol]

Stable Identifier

R-CFA-375314

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

NDC80, A0A8I3ML90

Locations in the PathwayBrowser

Expand all

Cell Cycle (Canis familiaris)

- Cell Cycle Checkpoints (Canis familiaris)
  - Mitotic Spindle Checkpoint (Canis familiaris)
    - Amplification of signal from the kinetochores (Canis familiaris)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Canis familiaris)
        
        MAD2 associates with the Mad1 kinetochore complex (Canis familiaris)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Canis familiaris)
        
        Mad1:kinetochore complex [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        KMN network [cytosol] (Canis familiaris)
        
        NDC80 complex [cytosol] (Canis familiaris)
        
        NDC80 [cytosol] (Canis familiaris)
        
        Mad1:kinetochore complex [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        KMN network [cytosol] (Canis familiaris)
        
        NDC80 complex [cytosol] (Canis familiaris)
        
        NDC80 [cytosol] (Canis familiaris)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Canis familiaris)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Canis familiaris)
        
        Mad1:kinetochore complex [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        KMN network [cytosol] (Canis familiaris)
        
        NDC80 complex [cytosol] (Canis familiaris)
        
        NDC80 [cytosol] (Canis familiaris)
        
        Mad1 binds kinetochore (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        KMN network [cytosol] (Canis familiaris)
        
        NDC80 complex [cytosol] (Canis familiaris)
        
        NDC80 [cytosol] (Canis familiaris)
        
        Mad1:kinetochore complex [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        KMN network [cytosol] (Canis familiaris)
        
        NDC80 complex [cytosol] (Canis familiaris)
        
        NDC80 [cytosol] (Canis familiaris)
        
        Release of activated MAD2 from kinetochores (Canis familiaris)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Canis familiaris)
        
        Mad1:kinetochore complex [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        KMN network [cytosol] (Canis familiaris)
        
        NDC80 complex [cytosol] (Canis familiaris)
        
        NDC80 [cytosol] (Canis familiaris)
        
        Mad1:kinetochore complex [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        KMN network [cytosol] (Canis familiaris)
        
        NDC80 complex [cytosol] (Canis familiaris)
        
        NDC80 [cytosol] (Canis familiaris)
- Cell Cycle, Mitotic (Canis familiaris)
  - M Phase (Canis familiaris)
    - Mitotic Metaphase and Anaphase (Canis familiaris)
      - Mitotic Anaphase (Canis familiaris)
        
        Separation of Sister Chromatids (Canis familiaris)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Canis familiaris)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        KMN network [cytosol] (Canis familiaris)
        
        NDC80 complex [cytosol] (Canis familiaris)
        
        NDC80 [cytosol] (Canis familiaris)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        KMN network [cytosol] (Canis familiaris)
        
        NDC80 complex [cytosol] (Canis familiaris)
        
        NDC80 [cytosol] (Canis familiaris)
        
        Separation of sister chromatids (Canis familiaris)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        KMN network [cytosol] (Canis familiaris)
        
        NDC80 complex [cytosol] (Canis familiaris)
        
        NDC80 [cytosol] (Canis familiaris)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        KMN network [cytosol] (Canis familiaris)
        
        NDC80 complex [cytosol] (Canis familiaris)
        
        NDC80 [cytosol] (Canis familiaris)
    - Mitotic Prometaphase (Canis familiaris)
      - EML4 and NUDC in mitotic spindle formation (Canis familiaris)
        
        EML4 recruits NUDC to mitotic spindle (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        KMN network [cytosol] (Canis familiaris)
        
        NDC80 complex [cytosol] (Canis familiaris)
        
        NDC80 [cytosol] (Canis familiaris)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        KMN network [cytosol] (Canis familiaris)
        
        NDC80 complex [cytosol] (Canis familiaris)
        
        NDC80 [cytosol] (Canis familiaris)
      - Kinetochore capture of astral microtubules (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        KMN network [cytosol] (Canis familiaris)
        
        NDC80 complex [cytosol] (Canis familiaris)
        
        NDC80 [cytosol] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        KMN network [cytosol] (Canis familiaris)
        
        NDC80 complex [cytosol] (Canis familiaris)
        
        NDC80 [cytosol] (Canis familiaris)
      - Resolution of Sister Chromatid Cohesion (Canis familiaris)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Canis familiaris)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Canis familiaris)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        KMN network [cytosol] (Canis familiaris)
        
        NDC80 complex [cytosol] (Canis familiaris)
        
        NDC80 [cytosol] (Canis familiaris)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        KMN network [cytosol] (Canis familiaris)
        
        NDC80 complex [cytosol] (Canis familiaris)
        
        NDC80 [cytosol] (Canis familiaris)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        KMN network [cytosol] (Canis familiaris)
        
        NDC80 complex [cytosol] (Canis familiaris)
        
        NDC80 [cytosol] (Canis familiaris)
        
        Kinetochore assembly (Canis familiaris)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Canis familiaris)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        KMN network [cytosol] (Canis familiaris)
        
        NDC80 complex [cytosol] (Canis familiaris)
        
        NDC80 [cytosol] (Canis familiaris)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        KMN network [cytosol] (Canis familiaris)
        
        NDC80 complex [cytosol] (Canis familiaris)
        
        NDC80 [cytosol] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        KMN network [cytosol] (Canis familiaris)
        
        NDC80 complex [cytosol] (Canis familiaris)
        
        NDC80 [cytosol] (Canis familiaris)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Canis familiaris)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        KMN network [cytosol] (Canis familiaris)
        
        NDC80 complex [cytosol] (Canis familiaris)
        
        NDC80 [cytosol] (Canis familiaris)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        KMN network [cytosol] (Canis familiaris)
        
        NDC80 complex [cytosol] (Canis familiaris)
        
        NDC80 [cytosol] (Canis familiaris)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Canis familiaris)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        KMN network [cytosol] (Canis familiaris)
        
        NDC80 complex [cytosol] (Canis familiaris)
        
        NDC80 [cytosol] (Canis familiaris)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        KMN network [cytosol] (Canis familiaris)
        
        NDC80 complex [cytosol] (Canis familiaris)
        
        NDC80 [cytosol] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
  - Signaling by Rho GTPases (Canis familiaris)
    - RHO GTPase Effectors (Canis familiaris)
      - RHO GTPases Activate Formins (Canis familiaris)
        
        AURKB phosphorylates DIAPH2-2 at kinetochores (Canis familiaris)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        KMN network [cytosol] (Canis familiaris)
        
        NDC80 complex [cytosol] (Canis familiaris)
        
        NDC80 [cytosol] (Canis familiaris)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        KMN network [cytosol] (Canis familiaris)
        
        NDC80 complex [cytosol] (Canis familiaris)
        
        NDC80 [cytosol] (Canis familiaris)
        
        CDC42:GTP recruits DIAPH2-2 to kinetochores (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        KMN network [cytosol] (Canis familiaris)
        
        NDC80 complex [cytosol] (Canis familiaris)
        
        NDC80 [cytosol] (Canis familiaris)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        KMN network [cytosol] (Canis familiaris)
        
        NDC80 complex [cytosol] (Canis familiaris)
        
        NDC80 [cytosol] (Canis familiaris)
        
        Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        KMN network [cytosol] (Canis familiaris)
        
        NDC80 complex [cytosol] (Canis familiaris)
        
        NDC80 [cytosol] (Canis familiaris)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        KMN network [cytosol] (Canis familiaris)
        
        NDC80 complex [cytosol] (Canis familiaris)
        
        NDC80 [cytosol] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        KMN network [cytosol] (Canis familiaris)
        
        NDC80 complex [cytosol] (Canis familiaris)
        
        NDC80 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3ML90

Gene Names

NDC80

Reference Genes

BioGPS Gene:480190 NDC80

ENSEMBL:ENSCAFG00845002475.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845002475.1 NDC80

Monarch:480190 NDC80

NCBI Gene:480190 NDC80

Reference Transcript

RefSeq:XM_537313.5 NDC80

Other Identifiers

480190

Cfa.3066.1.S1_at

Cfa.3066.1.S1_s_at

CfaAffx.28162.1.S1_at

GO:0000132

GO:0000278

GO:0000775

GO:0000776

GO:0000940

GO:0005634

GO:0005654

GO:0005694

GO:0005813

GO:0005815

GO:0005856

GO:0007010

GO:0007049

GO:0007052

GO:0007059

GO:0007163

GO:0008017

GO:0008092

GO:0008608

GO:0023052

GO:0031262

GO:0042802

GO:0043226

GO:0051298

GO:0051301

GO:0051310

GO:0051315

GO:0060090

GO:0090267

GO:0140014

GO:0140483

Participates

as a component of

NDC80 complex [cytosol] (Canis familiaris)

Inferred From

NDC80 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_537313.2

OpenTargets

ENSG00000080986

Ensembl

ENSCAFG00845002475, ENSCAFT00845004368, ENSCAFP00845003490

Cite Us!