Reactome | CEP57 [cytosol]

CEP57 [cytosol]

Stable Identifier

R-CFA-380271

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

CEP57, A0A8I3P1V5

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Canis familiaris)

- Cilium Assembly (Canis familiaris)
  - Anchoring of the basal body to the plasma membrane (Canis familiaris)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Canis familiaris)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Canis familiaris)
        
        mother centriole:C2CD3 [cytosol] (Canis familiaris)
        
        mother centriole [cytosol] (Canis familiaris)
        
        CEP57 [cytosol] (Canis familiaris)
      - mother centriole:C2CD3 [cytosol] (Canis familiaris)
        
        mother centriole [cytosol] (Canis familiaris)
        
        CEP57 [cytosol] (Canis familiaris)
    - C2CD3 binds the mother centriole (Canis familiaris)
      - mother centriole [cytosol] (Canis familiaris)
        
        CEP57 [cytosol] (Canis familiaris)
      - mother centriole:C2CD3 [cytosol] (Canis familiaris)
        
        mother centriole [cytosol] (Canis familiaris)
        
        CEP57 [cytosol] (Canis familiaris)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Canis familiaris)
      - basal body:transition zone proteins [cytosol] (Canis familiaris)
        
        basal body [cytosol] (Canis familiaris)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Canis familiaris)
        
        CEP57 [cytosol] (Canis familiaris)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Canis familiaris)
        
        basal body:transition zone proteins [cytosol] (Canis familiaris)
        
        basal body [cytosol] (Canis familiaris)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Canis familiaris)
        
        CEP57 [cytosol] (Canis familiaris)
    - CP110 and CEP97 dissociate from the centriole (Canis familiaris)
      - basal body [cytosol] (Canis familiaris)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Canis familiaris)
        
        CEP57 [cytosol] (Canis familiaris)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Canis familiaris)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Canis familiaris)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Canis familiaris)
        
        mother centriole:C2CD3 [cytosol] (Canis familiaris)
        
        mother centriole [cytosol] (Canis familiaris)
        
        CEP57 [cytosol] (Canis familiaris)
    - MARK4 binds ODF2 in the centriole (Canis familiaris)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Canis familiaris)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Canis familiaris)
        
        mother centriole:C2CD3 [cytosol] (Canis familiaris)
        
        mother centriole [cytosol] (Canis familiaris)
        
        CEP57 [cytosol] (Canis familiaris)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Canis familiaris)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Canis familiaris)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Canis familiaris)
        
        mother centriole:C2CD3 [cytosol] (Canis familiaris)
        
        mother centriole [cytosol] (Canis familiaris)
        
        CEP57 [cytosol] (Canis familiaris)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Canis familiaris)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Canis familiaris)
        
        basal body:transition zone proteins [cytosol] (Canis familiaris)
        
        basal body [cytosol] (Canis familiaris)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Canis familiaris)
        
        CEP57 [cytosol] (Canis familiaris)
    - Recruitment of transition zone proteins (Canis familiaris)
      - basal body [cytosol] (Canis familiaris)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Canis familiaris)
        
        CEP57 [cytosol] (Canis familiaris)
      - basal body:transition zone proteins [cytosol] (Canis familiaris)
        
        basal body [cytosol] (Canis familiaris)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Canis familiaris)
        
        CEP57 [cytosol] (Canis familiaris)
    - The distal appendage proteins recruit TTBK2 (Canis familiaris)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Canis familiaris)
        
        mother centriole:C2CD3 [cytosol] (Canis familiaris)
        
        mother centriole [cytosol] (Canis familiaris)
        
        CEP57 [cytosol] (Canis familiaris)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Canis familiaris)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Canis familiaris)
        
        mother centriole:C2CD3 [cytosol] (Canis familiaris)
        
        mother centriole [cytosol] (Canis familiaris)
        
        CEP57 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3P1V5

Gene Names

CEP57

Reference Genes

BioGPS Gene:476766 CEP57

ENSEMBL:ENSCAFG00845017787.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845017787.1 CEP57

Monarch:476766 CEP57

NCBI Gene:476766 CEP57

Reference Transcript

RefSeq:XM_533972.5 CEP57

Other Identifiers

476766

Cfa.10861.1.A1_at

CfaAffx.7065.1.S1_s_at

GO:0005634

GO:0005737

GO:0005794

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005874

GO:0007286

GO:0008017

GO:0008092

GO:0008543

GO:0017134

GO:0022414

GO:0023052

GO:0030154

GO:0034451

GO:0042802

GO:0042803

GO:0043015

GO:0043226

GO:0048856

GO:0051260

GO:0065003

Participates

as a component of

Inferred From

CEP57 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_533972.2

OpenTargets

ENSG00000166037

Ensembl

ENSCAFP00845024928, ENSCAFT00845031865, ENSCAFG00845017787

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