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ROCK2 [cytosol]
Stable Identifier
R-CFA-419058
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
ROCK2, A0A8I3SAZ7
Locations in the PathwayBrowser
Expand all
Developmental Biology (Canis familiaris)
Nervous system development (Canis familiaris)
Axon guidance (Canis familiaris)
EPH-Ephrin signaling (Canis familiaris)
EPHB-mediated forward signaling (Canis familiaris)
RHOA:GTP binds ROCK, activating it (Canis familiaris)
RHOA:GTP:ROCK1,ROCK2 [plasma membrane] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK2 [cytosol] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK2 [cytosol] (Canis familiaris)
Semaphorin interactions (Canis familiaris)
Sema4D in semaphorin signaling (Canis familiaris)
Sema4D induced cell migration and growth-cone collapse (Canis familiaris)
ROCK activation by RHO (Canis familiaris)
Activated ROCK:RhoA/B/C:GTP [plasma membrane] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK2 [cytosol] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK2 [cytosol] (Canis familiaris)
ROCK1,ROCK2:ROCKi [cytosol] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK2 [cytosol] (Canis familiaris)
ROCK1,2 bind ROCKi (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK2 [cytosol] (Canis familiaris)
ROCK1,ROCK2:ROCKi [cytosol] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK2 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (12/13) signalling events (Canis familiaris)
ROCK activation by RHO (Canis familiaris)
Activated ROCK:RhoA/B/C:GTP [plasma membrane] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK2 [cytosol] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK2 [cytosol] (Canis familiaris)
ROCK1,ROCK2:ROCKi [cytosol] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK2 [cytosol] (Canis familiaris)
ROCK1,2 bind ROCKi (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK2 [cytosol] (Canis familiaris)
ROCK1,ROCK2:ROCKi [cytosol] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK2 [cytosol] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by VEGF (Canis familiaris)
VEGFA-VEGFR2 Pathway (Canis familiaris)
Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Canis familiaris)
RHOA:GTP:Mg2+:Activated ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK2 [cytosol] (Canis familiaris)
RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Canis familiaris)
RHOA:GTP:ROCK1,ROCK2 [plasma membrane] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK2 [cytosol] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK2 [cytosol] (Canis familiaris)
ROCK1,ROCK2 are activated (Canis familiaris)
RHOA:GTP:Mg2+:Activated ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK2 [cytosol] (Canis familiaris)
RHOA:GTP:ROCK1,ROCK2 [plasma membrane] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK2 [cytosol] (Canis familiaris)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase Effectors (Canis familiaris)
RHO GTPases Activate ROCKs (Canis familiaris)
ROCK activation by RHO (Canis familiaris)
Activated ROCK:RhoA/B/C:GTP [plasma membrane] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK2 [cytosol] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK2 [cytosol] (Canis familiaris)
ROCK1,ROCK2:ROCKi [cytosol] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK2 [cytosol] (Canis familiaris)
ROCK1,2 bind ROCKi (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK2 [cytosol] (Canis familiaris)
ROCK1,ROCK2:ROCKi [cytosol] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
ROCK2 [cytosol] (Canis familiaris)
RHO GTPase cycle (Canis familiaris)
RHOA GTPase cycle (Canis familiaris)
RHOA binds effectors at the plasma membrane (Canis familiaris)
RHOA plasma membrane effectors [cytosol] (Canis familiaris)
ROCK2 [cytosol] (Canis familiaris)
RHOA:GTP:cytosolic RHOA effectors [plasma membrane] (Canis familiaris)
RHOA plasma membrane effectors [cytosol] (Canis familiaris)
ROCK2 [cytosol] (Canis familiaris)
RHOB GTPase cycle (Canis familiaris)
RHOB binds effectors at the plasma membrane (Canis familiaris)
RHOB effectors (plasma membrane) [cytosol] (Canis familiaris)
ROCK2 [cytosol] (Canis familiaris)
RHOB:GTP:cytosolic RHOB effectors [plasma membrane] (Canis familiaris)
RHOB effectors (plasma membrane) [cytosol] (Canis familiaris)
ROCK2 [cytosol] (Canis familiaris)
RHOBTB GTPase Cycle (Canis familiaris)
RHOBTB1 GTPase cycle (Canis familiaris)
RHOBTB1 binds interacting proteins at the endosome membrane (Canis familiaris)
RHOBTB1 interacting proteins [cytosol] (Canis familiaris)
ROCK2 [cytosol] (Canis familiaris)
RHOBTB1:GTP:RHOBTB1 interacting proteins [endosome membrane] (Canis familiaris)
RHOBTB1 interacting proteins [cytosol] (Canis familiaris)
ROCK2 [cytosol] (Canis familiaris)
RHOC GTPase cycle (Canis familiaris)
RHOC binds effectors at the plasma membrane (Canis familiaris)
RHOC effectors [cytosol] (Canis familiaris)
ROCK2 [cytosol] (Canis familiaris)
RHOC:GTP:RHOC effectors [plasma membrane] (Canis familiaris)
RHOC effectors [cytosol] (Canis familiaris)
ROCK2 [cytosol] (Canis familiaris)
RHOH GTPase cycle (Canis familiaris)
RHOH binds effectors at the plasma membrane (Canis familiaris)
RHOH effectors [cytosol] (Canis familiaris)
ROCK2 [cytosol] (Canis familiaris)
RHOH:GTP:RHOH effectors [plasma membrane] (Canis familiaris)
RHOH effectors [cytosol] (Canis familiaris)
ROCK2 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3SAZ7
Gene Names
ROCK2
Reference Genes
ENSEMBL:ENSCAFG00845027461.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845027461.1 ROCK2
Other Identifiers
482970
CfaAffx.6269.1.S1_s_at
GO:0001934
GO:0003012
GO:0003824
GO:0004672
GO:0004674
GO:0005524
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006468
GO:0006939
GO:0007010
GO:0007165
GO:0007249
GO:0007266
GO:0010595
GO:0010628
GO:0010825
GO:0016525
GO:0016740
GO:0023052
GO:0030154
GO:0030335
GO:0030866
GO:0031267
GO:0032956
GO:0034330
GO:0036211
GO:0036464
GO:0043226
GO:0044788
GO:0045019
GO:0045616
GO:0048856
GO:0048870
GO:0051298
GO:0051496
GO:0071394
GO:0072518
GO:0072659
GO:0140096
GO:0150033
GO:1902004
GO:1902966
GO:1902993
GO:1903140
GO:1903347
Participates
as a member of
RHOA plasma membrane effectors [cytosol] (Canis familiaris)
RHOC effectors [cytosol] (Canis familiaris)
RHOBTB1 interacting proteins [cytosol] (Canis familiaris)
RHOB effectors (plasma membrane) [cytosol] (Canis familiaris)
ROCK1,ROCK2 [cytosol] (Canis familiaris)
as a candidate of
RHOH effectors [cytosol] (Canis familiaris)
Inferred From
Activated ROCK2 [cytosol]
(Homo sapiens)
ROCK2 [cytosol]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000134318
Ensembl
ENSCAFG00845027461
,
ENSCAFP00845038396
,
ENSCAFT00845048945
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