Reactome | ARHGEF7 [cytosol]

ARHGEF7 [cytosol]

Stable Identifier

R-CFA-430346

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

ARHGEF7, A0A8I3S560

Locations in the PathwayBrowser

Expand all

Developmental Biology (Canis familiaris)

- Nervous system development (Canis familiaris)
  - Axon guidance (Canis familiaris)
    - EPH-Ephrin signaling (Canis familiaris)
      - Ephrin signaling (Canis familiaris)
        
        GIT1 binds bPIX (Canis familiaris)
        
        ARHGEF7 [cytosol] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Canis familiaris)
        
        ARHGEF7 [cytosol] (Canis familiaris)
        
        PAK binds RAC and bPIX (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Canis familiaris)
        
        ARHGEF7 [cytosol] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Canis familiaris)
        
        ARHGEF7 [cytosol] (Canis familiaris)
        
        PAKs autophosphorylate (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Canis familiaris)
        
        ARHGEF7 [cytosol] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Canis familiaris)
        
        ARHGEF7 [cytosol] (Canis familiaris)
        
        PAKs phosphorylate MLC (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Canis familiaris)
        
        ARHGEF7 [cytosol] (Canis familiaris)
        
        bPIX exchanges GTP for GDP on RAC, activating it (Canis familiaris)
        
        ARHGEF7 [cytosol] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Canis familiaris)
        
        ARHGEF7 [cytosol] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Canis familiaris)
        
        ARHGEF7 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3S560

Gene Names

ARHGEF7

Reference Genes

ENSEMBL:ENSCAFG00845021560.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845021560.1 ARHGEF7

Other Identifiers

485552

Cfa.5236.1.A1_at

CfaAffx.10175.1.S1_s_at

GO:0000322

GO:0002244

GO:0005085

GO:0005515

GO:0005773

GO:0005829

GO:0005886

GO:0019901

GO:0023052

GO:0030027

GO:0030032

GO:0030154

GO:0035556

GO:0043226

GO:0048856

GO:0060124

GO:0098772

GO:0098794

Participates

as a candidate of

as an input of

GIT1 binds bPIX (Canis familiaris)

as a component of

as a member of

GEFs [cytosol] (Canis familiaris)

Inferred From

ARHGEF7 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000102606

Ensembl

ENSCAFG00845021560, ENSCAFT00845038352, ENSCAFP00845030026