Reactome | NEFL [cytosol]

NEFL [cytosol]

Stable Identifier

R-CFA-432284

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

NEFL, A0A8I3NI39

Locations in the PathwayBrowser

Expand all

Neuronal System (Canis familiaris)

- Transmission across Chemical Synapses (Canis familiaris)
  - Neurotransmitter receptors and postsynaptic signal transmission (Canis familiaris)
    - Activation of NMDA receptors and postsynaptic events (Canis familiaris)
      - Unblocking of NMDA receptors, glutamate binding and activation (Canis familiaris)
        
        Ca2+ influx into the post-synaptic cell (Canis familiaris)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Canis familiaris)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Canis familiaris)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Canis familiaris)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Canis familiaris)
        
        NEFL [cytosol] (Canis familiaris)
        
        Membrane depolarization upon activation of Ca impermeable AMPA receptors (Canis familiaris)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Canis familiaris)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Canis familiaris)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Canis familiaris)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Canis familiaris)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Canis familiaris)
        
        NEFL [cytosol] (Canis familiaris)

Signal Transduction (Canis familiaris)

- MAPK family signaling cascades (Canis familiaris)
  - MAPK1/MAPK3 signaling (Canis familiaris)
    - RAF/MAP kinase cascade (Canis familiaris)
      - RAS GEFs promote RAS nucleotide exchange (Canis familiaris)
        
        RAS GEFs [plasma membrane] (Canis familiaris)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Canis familiaris)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Canis familiaris)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Canis familiaris)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Canis familiaris)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Canis familiaris)
        
        NEFL [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NI39

Gene Names

NEFL

Reference Genes

BioGPS Gene:100856220 NEFL

ENSEMBL:ENSCAFG00845014438.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845014438.1 NEFL

KEGG Gene (Canis lupus familiaris):100856220 NEFL

Monarch:100856220 NEFL

NCBI Gene:100856220 NEFL

Reference Transcript

RefSeq:XM_003639880.3 NEFL

Other Identifiers

100856220

Cfa.10952.1.A1_s_at

GO:0000226

GO:0005198

GO:0005200

GO:0005737

GO:0005856

GO:0005882

GO:0005883

GO:0007010

GO:0007018

GO:0007409

GO:0008089

GO:0008090

GO:0012501

GO:0014012

GO:0019896

GO:0023052

GO:0030154

GO:0030424

GO:0030674

GO:0031133

GO:0031594

GO:0033693

GO:0034330

GO:0040011

GO:0042802

GO:0043005

GO:0043226

GO:0045109

GO:0045110

GO:0048812

GO:0048856

GO:0050772

GO:0050877

GO:0050885

GO:0060052

GO:0060090

GO:0090128

GO:0097049

GO:0098685

GO:0098981

GO:0099160

GO:0099170

GO:0099182

GO:0099184

GO:2000672

Participates

as a component of

Inferred From

NEFL [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_003639928.1

OpenTargets

ENSG00000277586

Ensembl

ENSCAFP00845020363, ENSCAFT00845025840, ENSCAFG00845014438