Reactome | PROK1 [extracellular region]

PROK1 [extracellular region]

Stable Identifier

R-CFA-444616

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

extracellular region

Synonyms

PROK1, F1PBN0

Locations in the PathwayBrowser

Expand all

Signal Transduction (Canis familiaris)

- Signaling by GPCR (Canis familiaris)
  - GPCR downstream signalling (Canis familiaris)
    - G alpha (q) signalling events (Canis familiaris)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        PROKR1,PROKR2:PROK1,PROK2 [plasma membrane] (Canis familiaris)
        
        PROK1,PROK2 [extracellular region] (Canis familiaris)
        
        PROK1 [extracellular region] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        PROKR1,PROKR2:PROK1,PROK2 [plasma membrane] (Canis familiaris)
        
        PROK1,PROK2 [extracellular region] (Canis familiaris)
        
        PROK1 [extracellular region] (Canis familiaris)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        PROKR1,PROKR2:PROK1,PROK2 [plasma membrane] (Canis familiaris)
        
        PROK1,PROK2 [extracellular region] (Canis familiaris)
        
        PROK1 [extracellular region] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        PROKR1,PROKR2:PROK1,PROK2 [plasma membrane] (Canis familiaris)
        
        PROK1,PROK2 [extracellular region] (Canis familiaris)
        
        PROK1 [extracellular region] (Canis familiaris)
      - The Ligand:GPCR:Gq complex dissociates (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        PROKR1,PROKR2:PROK1,PROK2 [plasma membrane] (Canis familiaris)
        
        PROK1,PROK2 [extracellular region] (Canis familiaris)
        
        PROK1 [extracellular region] (Canis familiaris)
        
        Ligands of GPCRs that activate Gq/11 [extracellular region] (Canis familiaris)
        
        PROK1,PROK2 [extracellular region] (Canis familiaris)
        
        PROK1 [extracellular region] (Canis familiaris)
  - GPCR ligand binding (Canis familiaris)
    - Class A/1 (Rhodopsin-like receptors) (Canis familiaris)
      - Peptide ligand-binding receptors (Canis familiaris)
        
        Prokineticin receptors bind prokineticin (Canis familiaris)
        
        PROK1,PROK2 [extracellular region] (Canis familiaris)
        
        PROK1 [extracellular region] (Canis familiaris)
        
        PROKR1,PROKR2:PROK1,PROK2 [plasma membrane] (Canis familiaris)
        
        PROK1,PROK2 [extracellular region] (Canis familiaris)
        
        PROK1 [extracellular region] (Canis familiaris)

External Reference Information

External Reference

UniProt:F1PBN0

Gene Names

PROK1

Reference Genes

ENSEMBL:ENSCAFG00000019786

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000019786 PROK1

Other Identifiers

CfaAffx.30265.1.S1_at

GO:0000187

GO:0001664

GO:0003674

GO:0005575

GO:0005576

GO:0006464

GO:0007165

GO:0007623

GO:0008150

GO:0008283

GO:0008284

GO:0045765

GO:0048646

GO:0048856

Participates

as a member of

PROK1,PROK2 [extracellular region] (Canis familiaris)

Inferred From

PROK1 [extracellular region] (Homo sapiens)

Cross References

OpenTargets

ENSG00000143125

Ensembl

ENSCAFT00000031462, ENSCAFP00000029286, ENSCAFG00000019786

VGNC

45010