Reactome | phospho-CAMK2A [cytosol]

phospho-CAMK2A [cytosol]

Stable Identifier

R-CFA-445368

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

p-T286-CAMK2A, F1PB67

Locations in the PathwayBrowser

Expand all

Immune System (Canis familiaris)

- Cytokine Signaling in Immune system (Canis familiaris)
  - FLT3 Signaling (Canis familiaris)
    - RAF/MAP kinase cascade (Canis familiaris)
      - RAF activation (Canis familiaris)
        
        Phosphorylation of RAF (Canis familiaris)
        
        RAF activating kinases [plasma membrane] (Canis familiaris)
        
        p-T286-CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Canis familiaris)
        
        p-T286-CaMKII dodecamer [cytosol] (Canis familiaris)
        
        p-T286-CAMK2A,p-T287-CAMK2B,(p-T287-CAMK2D,p-T287-CAMK2G) [cytosol] (Canis familiaris)
        
        phospho-CAMK2A [cytosol] (Canis familiaris)
  - Interferon Signaling (Canis familiaris)
    - Interferon gamma signaling (Canis familiaris)
      - Phosphorylation of STAT1 at Ser727 (Canis familiaris)
        
        CaMKII and PKC-delta [cytosol] (Canis familiaris)
        
        CaMKII [cytosol] (Canis familiaris)
        
        phospho-CAMK2A [cytosol] (Canis familiaris)

Neuronal System (Canis familiaris)

- Transmission across Chemical Synapses (Canis familiaris)
  - Neurotransmitter receptors and postsynaptic signal transmission (Canis familiaris)
    - Activation of NMDA receptors and postsynaptic events (Canis familiaris)
      - Unblocking of NMDA receptors, glutamate binding and activation (Canis familiaris)
        
        Membrane depolarization upon activation of Ca impermeable AMPA receptors (Canis familiaris)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Canis familiaris)
        
        p-T286-CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Canis familiaris)
        
        p-T286-CaMKII dodecamer [cytosol] (Canis familiaris)
        
        p-T286-CAMK2A,p-T287-CAMK2B,(p-T287-CAMK2D,p-T287-CAMK2G) [cytosol] (Canis familiaris)
        
        phospho-CAMK2A [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:F1PB67

Gene Names

CAMK2A

Reference Genes

BioGPS Gene:612941 CAMK2A

ENSEMBL:ENSCAFG00000018163

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000018163 CAMK2A

Monarch:612941 CAMK2A

NCBI Gene:612941 CAMK2A

Reference Transcript

RefSeq:XM_005619301.2 CAMK2A

Other Identifiers

612941

Cfa.9387.1.A1_at

CfaAffx.27869.1.S1_s_at

GO:0000166

GO:0003674

GO:0004672

GO:0004674

GO:0004683

GO:0005516

GO:0005524

GO:0005575

GO:0005622

GO:0005737

GO:0006464

GO:0006468

GO:0008150

GO:0016301

GO:0043005

GO:0043167

Participant Of

hasComponent

hasMember

p-T286-CAMK2A,p-T287-CAMK2B,(p-T287-CAMK2D,p-T287-CAMK2G) [cytosol]

Other forms of this molecule

phospho-CAMK2A [plasma membrane]

phospho-CAMK2A [nucleoplasm]

phospho-CAMK2A [endocytic vesicle membrane]

phospho-CAMK2A [cytosol]

CAMK2A [cytosol]

Inferred From

p-T286-CAMK2A [cytosol] (Homo sapiens)

CaMKII alpha/beta [cytosol] (Homo sapiens)

Modified Residues

Name

O-phospho-L-threonine at 286 (in Homo sapiens)

Coordinate

286

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

XP_005619358.1

OpenTargets

ENSG00000070808

Ensembl

ENSCAFT00000028867, ENSCAFP00000026845, ENSCAFG00000018163

VGNC

38680