Reactome | IL1RAP [plasma membrane]

IL1RAP [plasma membrane]

Stable Identifier

R-CFA-445745

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

IL1RAP-1, A0A8I3PN81

Locations in the PathwayBrowser

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Signal Transduction (Canis familiaris)

- Intracellular signaling by second messengers (Canis familiaris)
  - PIP3 activates AKT signaling (Canis familiaris)
    - Negative regulation of the PI3K/AKT network (Canis familiaris)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
        
        PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
        
        IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Canis familiaris)
        
        IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Canis familiaris)
        
        IL33:IL1RL1:IL1RAP-1 [plasma membrane] (Canis familiaris)
        
        IL1RAP [plasma membrane] (Canis familiaris)
    - PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
      - IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Canis familiaris)
        
        IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Canis familiaris)
        
        IL33:IL1RL1:IL1RAP-1 [plasma membrane] (Canis familiaris)
        
        IL1RAP [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3PN81

Gene Names

IL1RAP

Reference Genes

ENSEMBL:ENSCAFG00845024451.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845024451.1 IL1RAP

Reference Transcript

RefSeq:XM_005639831.2 IL1RAP

Other Identifiers

488126

CfaAffx.21660.1.S1_at

GO:0002114

GO:0004908

GO:0007155

GO:0007165

GO:0015026

GO:0019221

GO:0023052

GO:0032736

GO:0032753

GO:0032754

GO:0032755

GO:0034330

GO:0038172

GO:0045202

GO:0048856

GO:0051965

GO:0060089

GO:0070498

GO:0098978

GO:0099151

GO:0099545

GO:0099560

GO:1905606

Participates

as an input of

as a component of

Inferred From

IL1RAP-1 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_005639888.1

OpenTargets

ENSG00000196083

Ensembl

ENSCAFP00845034043, ENSCAFG00845024451, ENSCAFT00845043454

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