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phospho-IRAK4 [cytosol]
Stable Identifier
R-CFA-446649
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
p-T342,T345,S346-IRAK4, A0A8I3Q059
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-1 family signaling (Canis familiaris)
Interleukin-1 signaling (Canis familiaris)
Hyperphosphorylated IRAK1 associates with TRAF6 (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
phospho-IRAK4 [cytosol] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
phospho-IRAK4 [cytosol] (Canis familiaris)
IRAK1 binds to MYD88 within the IL1R complex (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
phospho-IRAK4 [cytosol] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
phospho-IRAK4 [cytosol] (Canis familiaris)
IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
phospho-IRAK4 [cytosol] (Canis familiaris)
IRAK4 is activated by autophosphorylation (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
phospho-IRAK4 [cytosol] (Canis familiaris)
IRAK4 phosphorylates IRAK1 (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
phospho-IRAK4 [cytosol] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
phospho-IRAK4 [cytosol] (Canis familiaris)
phospho-IRAK4 [cytosol] (Canis familiaris)
IRAK4-activated IRAK1 autophosphorylates (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
phospho-IRAK4 [cytosol] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
phospho-IRAK4 [cytosol] (Canis familiaris)
TRAF6 binding leads to IRAK1:TRAF6 release (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
phospho-IRAK4 [cytosol] (Canis familiaris)
phospho-IRAK4 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3Q059
Gene Names
IRAK4
Reference Genes
ENSEMBL:ENSCAFG00845029210.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845029210.1 IRAK4
Other Identifiers
486601
CfaAffx.15239.1.S1_at
CfaAffx.15248.1.S1_s_at
CfaAffx.15255.1.S1_s_at
GO:0000287
GO:0002376
GO:0002446
GO:0003824
GO:0004672
GO:0004674
GO:0005149
GO:0005524
GO:0006468
GO:0007165
GO:0009986
GO:0016301
GO:0016740
GO:0019221
GO:0019901
GO:0023052
GO:0036211
GO:0038172
GO:0043123
GO:0048870
GO:0070498
GO:0140096
GO:1990266
Participates
as an output of
TRAF6 binding leads to IRAK1:TRAF6 release (Canis familiaris)
as a component of
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
Other forms of this molecule
IRAK4 [cytosol]
Inferred From
p-T342,T345,S346-IRAK4 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 342 (in Homo sapiens)
Coordinate
342
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at 345 (in Homo sapiens)
Coordinate
345
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 346 (in Homo sapiens)
Coordinate
346
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
OpenTargets
ENSG00000198001
Ensembl
ENSCAFP00845040563
,
ENSCAFG00845029210
,
ENSCAFT00845051698
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