Reactome | IL33 [extracellular region]

IL33 [extracellular region]

Stable Identifier

R-CFA-448567

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

extracellular region

Synonyms

IL33, O97863

Locations in the PathwayBrowser

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Signal Transduction (Canis familiaris)

- Intracellular signaling by second messengers (Canis familiaris)
  - PIP3 activates AKT signaling (Canis familiaris)
    - Negative regulation of the PI3K/AKT network (Canis familiaris)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
        
        PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
        
        IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Canis familiaris)
        
        IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Canis familiaris)
        
        IL33:IL1RL1:IL1RAP-1 [plasma membrane] (Canis familiaris)
        
        IL1RL1:IL33 [plasma membrane] (Canis familiaris)
        
        IL33 [extracellular region] (Canis familiaris)
    - PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
      - IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Canis familiaris)
        
        IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Canis familiaris)
        
        IL33:IL1RL1:IL1RAP-1 [plasma membrane] (Canis familiaris)
        
        IL1RL1:IL33 [plasma membrane] (Canis familiaris)
        
        IL33 [extracellular region] (Canis familiaris)

External Reference Information

External Reference

UniProt:O97863

Gene Names

IL33

Reference Genes

BioGPS Gene:403810 IL33

ENSEMBL:ENSCAFG00040010108

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00040010108.1 IL33

KEGG Gene (Canis lupus familiaris):403810 IL33

Monarch:403810 IL33

NCBI Gene:403810 IL33

Reference Transcript

RefSeq:NM_001003180.1 IL33

Participates

as a component of

IL1RL1:IL33 [plasma membrane] (Canis familiaris)

Other forms of this molecule

IL33 [nucleoplasm]

IL33 [nucleoplasm]

Inferred From

IL33 [extracellular region] (Homo sapiens)

Cross References

RefSeq

NP_001003180.1

OpenTargets

ENSG00000137033

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