Reactome | CDC42 [plasma membrane]

CDC42 [plasma membrane]

Stable Identifier

R-CFA-449545

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

P60952

Locations in the PathwayBrowser

Expand all

Developmental Biology (Canis familiaris)

- Myogenesis (Canis familiaris)
  - Nuclear translocation of p38 MAPK (Canis familiaris)
    - ABL1:JLP:CDO complex [plasma membrane] (Canis familiaris)
      - Cadherin-catenin:JLP:CDO:BOC:Bnip2-Cdc42 [plasma membrane] (Canis familiaris)
        
        Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Canis familiaris)
        
        CDC42:GTP [plasma membrane] (Canis familiaris)
        
        CDC42 [plasma membrane] (Canis familiaris)
    - pp38 alpha/beta/gamma:ABL1:JLP:CDO complex [plasma membrane] (Canis familiaris)
      - ABL1:JLP:CDO complex [plasma membrane] (Canis familiaris)
        
        Cadherin-catenin:JLP:CDO:BOC:Bnip2-Cdc42 [plasma membrane] (Canis familiaris)
        
        Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Canis familiaris)
        
        CDC42:GTP [plasma membrane] (Canis familiaris)
        
        CDC42 [plasma membrane] (Canis familiaris)
- Nervous system development (Canis familiaris)
  - Axon guidance (Canis familiaris)
    - EPH-Ephrin signaling (Canis familiaris)
      - EPHB-mediated forward signaling (Canis familiaris)
        
        CDC42 and PIP2 bind WASL, activating it (Canis familiaris)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Canis familiaris)
        
        CDC42:GTP [plasma membrane] (Canis familiaris)
        
        CDC42 [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Canis familiaris)
        
        CDC42:GTP [plasma membrane] (Canis familiaris)
        
        CDC42 [plasma membrane] (Canis familiaris)
        
        N-WASP binds ARP2/3 and G-actin (Canis familiaris)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Canis familiaris)
        
        CDC42:GTP [plasma membrane] (Canis familiaris)
        
        CDC42 [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Canis familiaris)
        
        CDC42:GTP [plasma membrane] (Canis familiaris)
        
        CDC42 [plasma membrane] (Canis familiaris)
    - Netrin-1 signaling (Canis familiaris)
      - DCC mediated attractive signaling (Canis familiaris)
        
        Activation of Cdc42 (Canis familiaris)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Canis familiaris)
        
        CDC42:GTP [plasma membrane] (Canis familiaris)
        
        CDC42 [plasma membrane] (Canis familiaris)
        
        Recruitment and activation of N-WASP by Cdc42 (Canis familiaris)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Canis familiaris)
        
        CDC42:GTP [plasma membrane] (Canis familiaris)
        
        CDC42 [plasma membrane] (Canis familiaris)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane] (Canis familiaris)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Canis familiaris)
        
        CDC42:GTP [plasma membrane] (Canis familiaris)
        
        CDC42 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:P60952

Reference Genes

ENSEMBL:ENSCAFG00030002163

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000014707.6

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00030002163.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00040001840.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00040002443.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00805001040

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845000796.1

Reference Transcript

RefSeq:NM_001003254.2

Other Identifiers

119863888

Cfa.15509.1.S1_at

Cfa.15509.2.S1_at

CfaAffx.12195.1.S1_s_at

CfaAffx.22663.1.S1_at

GO:0003824

GO:0003924

GO:0005525

GO:0007264

GO:0016787

GO:0023052

Participates

as a candidate of

as a component of

as an input of

CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Canis familiaris)

Other forms of this molecule

CDC42 [endoplasmic reticulum membrane]

CDC42 [cytosol]

Inferred From

CDC42 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001003254.1

Ensembl

ENSCAFP00845001027, ENSCAFT00845001325, ENSCAFG00845000796, ENSCAFP00845001022, ENSCAFT00845001333

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