Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
IL5RA [plasma membrane]
Stable Identifier
R-CFA-450072
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
plasma membrane
Synonyms
IL5RA, A0A8I3RX48
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-2 family signaling (Canis familiaris)
Interleukin receptor SHC signaling (Canis familiaris)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
Phosphorylated SHC recruits GRB2:SOS1 (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
Phosphorylated SHC1 recruits GRB2:GAB2 (Canis familiaris)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
Phosphorylated SHC1 recruits SHIP (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Canis familiaris)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
The SHC1:SHIP1 complex is stabilized by GRB2 (Canis familiaris)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Canis familiaris)
14-3-3 zeta binding allows recruitment of PI3K (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
Activation of STAT5a/b by JAK2 (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2:p-STAT5 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, activated JAK2:p-STAT5 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
IL3RB is phosphorylated on Ser-585 (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
Interleukin receptor SHC signaling (Canis familiaris)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
Phosphorylated SHC recruits GRB2:SOS1 (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
Phosphorylated SHC1 recruits GRB2:GAB2 (Canis familiaris)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
Phosphorylated SHC1 recruits SHIP (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Canis familiaris)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
The SHC1:SHIP1 complex is stabilized by GRB2 (Canis familiaris)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
Interleukin-5 receptor alpha subunit binds Interleukin-5 (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
JAK2 is phosphorylated, activated (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
Recruitment of SHC1 is mediated by Y593 of the common beta chain (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc:SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
SHP1 and SHP2 bind the common beta chain (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593)-Bc [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
STAT5 is recruited by JAK2 (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
The receptor is activated (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
High affinity binding complexes of interleukin receptors using the Common beta chain [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
Tyrosine kinases phosphorylate the receptor (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
Tyrosine kinases that phosphorylate the Common beta chain [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
p-S585-IL3RB binds 14-3-3 proteins (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
p-STAT5 dissociates from the receptor complex (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2:p-STAT5 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, activated JAK2:p-STAT5 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
Signal Transduction (Canis familiaris)
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
RAS GEFs promote RAS nucleotide exchange (Canis familiaris)
RAS GEFs [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5RA [plasma membrane] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3RX48
Gene Names
IL5RA
Reference Genes
ENSEMBL:ENSCAFG00845012603.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845012603.1 IL5RA
Other Identifiers
476553
CfaAffx.9960.1.S1_at
GO:0002376
GO:0002437
GO:0004896
GO:0004914
GO:0005515
GO:0005886
GO:0006954
GO:0016020
GO:0023052
GO:0032674
GO:0038043
GO:0060089
GO:0071310
Participates
as an input of
Interleukin-5 receptor alpha subunit binds Interleukin-5 (Canis familiaris)
as a component of
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
Inferred From
IL5RA [plasma membrane]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000091181
Ensembl
ENSCAFP00845017635
,
ENSCAFT00845022452
,
ENSCAFG00845012603
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
