Reactome | K63polyUb [cytosol]

K63polyUb [cytosol]

Stable Identifier

R-CFA-450152

Type

Polymer

Species

Canis familiaris

Compartment

cytosol

Locations in the PathwayBrowser

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General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

repeated unit

K63-Ub [cytosol] (Canis familiaris)

Participates

as an output of

TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Canis familiaris)
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Canis familiaris)
USP13 deubiquitinates BECN1,USP10 (Canis familiaris)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Canis familiaris)
USP19 deubiquitinates RNF123 (Canis familiaris)
BRISC complex deubiquitinates NLRP3 (Canis familiaris)
ATXN3 family cleave Ub chains (Canis familiaris)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Canis familiaris)
CYLD deubiquitinates NEMO (Canis familiaris)
TNFAIP3 (A20) deubiquitinates RIP2 (Canis familiaris)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation (Canis familiaris)
Activated TRAF6 synthesizes unanchored polyubiquitin chains (Canis familiaris)

as an input of

STAMBPL1 is a deubiquitinase (Canis familiaris)
PSMD14 cleaves K63-linked ubiquitin (Canis familiaris)
ATXN3 family cleave Ub chains (Canis familiaris)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Canis familiaris)
TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Canis familiaris)
Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
(Canis familiaris)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Canis familiaris)
Ubiquitination of NEMO by TRAF6 (Canis familiaris)
K63polyUb-TRAF6 ubiquitinates TAK1 (Canis familiaris)
TRAF6 oligomer autoubiquitinates (Canis familiaris)
Auto-ubiquitination of TRAF6 (Canis familiaris)
K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Canis familiaris)
Auto-ubiquitination of TRAF6 (Canis familiaris)
Pellino ubiquitinates hp-IRAK1 (Canis familiaris)
RIP2 induces K63-linked ubiquitination of NEMO (Canis familiaris)
Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Canis familiaris)
RIP2 is K63 polyubiquitinated (Canis familiaris)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Canis familiaris)
Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Canis familiaris)

as a component of

p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane] (Canis familiaris)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Canis familiaris)
UBE2N:UBE2V1:K63polyUb [cytosol] (Canis familiaris)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] (Canis familiaris)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] (Canis familiaris)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Canis familiaris)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Canis familiaris)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane] (Canis familiaris)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] (Canis familiaris)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Canis familiaris)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Canis familiaris)

as a member of

PolyUb [cytosol] (Canis familiaris)

Inferred From

Short K63polyUb [cytosol] (Homo sapiens)

K63polyUb [cytosol] (Homo sapiens)

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